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G. PRATVIEL

Put on-line by Gaëtan Havet, Jean-Luc STIGLIANI

Metals in Biology and Medicinal Chemistry


Metals in Biology and Medicinal Chemistry

Group leader : Geneviève Pratviel - Directeur de Recherche, CNRS


Genevieve Pratviel’s group is focused on the understanding at the molecular level of the processes involving metal ions in biology especially when they are related to health. Currently, team’s projects deal with (i) implication of the redox reactivity of metal ions in the mechanism of action of drugs, (ii) disruption of metal homeostasis leading to oxidative damage and cell dysfunction, and (iii) the structural and functional role of metal ions in proteins and protein models. These projects link fundamental research to applications in biotechnology and drug design in the field of cancer, infectious diseases (tuberculosis, malaria…), and Alzheimer disease.



- Research Topics

- Job opportunities

Permanent staff
Dr Geneviève PRATVIEL  
DR
CNRS
+33 5 61 33 31 46
Research topics
Dr Anne ROBERT  
DR
CNRS
+33 5 61 33 31 26
Research topics
Dr Bernard MEUNIER 
Emeritus Director of Research
CNRS
+05 61 33 31 84
CV
Prof. Jean BERNADOU 
Emeritus Professor
Université Paul Sabatier
+33 5 61 33 31 17
Research topics
Prof. Vania BERNARDES-GENISSON
Professor
Université Paul Sabatier
+33 5 61 33 31 50
Research topics
Prof. Pierre VERHAEGHE 
Professor
Université Paul Sabatier
+33 5 61 33 32 36
+33 5 62 25 68 67
CV

Research topics

Dr Céline DERAEVE 
Assistant Professor
Université Paul Sabatier
+33 5 61 33 31 48
CV
Colin BONDUELLE 
CR
CNRS
+33 5 61 33 32 36
CV

Research topics
Dr Jean-Luc STIGLIANI 
Assistant Professor, UPS
+33 5 61 33 31 50
Research topics
 Emmanuelle MOTHES 
 Tc, CNRS
+33 5 61 33 31 50

Non-permanent staff
Julie LABORDE 
PhD student
Chemical Engineer ESCOM
+33 5 61 33 31 48
CV
Aurélien CHOLLET 
PhD student
+33 5 61 33 31 50
Dr Michel NGUYEN 
Engineer
+33 5 61 33 31 26
Cyril FERSING 
PhD student, Pharmacist Intern AP-HM
Co-direction Aix-Marseille University
+33 5 61 33 32 36



- Collaborations

- Publications since 2008

- Recent Publications:

Reviews
  • Schistosomiasis Chemotherapy. S. A.-L. Thetiot-Laurent, J. Boissier, A. Robert, B. Meunier. Angew. Chem. Int. Ed. 52, 7936-7956 (2013). Abstract
  • Isoniazid: an update on the multiple mechanisms for a singular action. V. Bernardes-Genisson, C. Deraeve, A. Chollet, J. Bernadou, G. Pratviel. Curr. Med. Chem., 20, 4370-4385 (2013). Abstract
  • Oxidative Damage Mediated by Transition Metal Ions and Their Complexes. G. PRATVIEL Met. Ions Life Sci. 10 , 201-216 (2012). Abstract

Articles
  • Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease. M. Nguyen, A. Robert, A. Sournia-Saquet, L. Vendier, B. Meunier. Chem. Eur. J., 20, 6771-6785 (2014) Abstract
  • Interaction of cationic manganese porphyrin with G-quadruplex nucleic acids probed by differential labeling of the two faces of the porphyrin. V. Pradines, G. Pratviel. Angew. Chem. Int. Ed. 52, 2185-2188 (2013) Abstract
  • Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug. A. Robert, C. Claparols, B. Witkowski, F. Benoit-Vical. Antimicrob. Agents Ch., 57 (8), 3998-4000 (2013) Abstract
  • Protonation state of trans axial water molecule switches the reactivity of high-valent manganese-oxo porphyrin. J. Trzcionka, J. Irvoas, G. Pratviel New J. Chem., 37, 3581-3590 (2013) Abstract
  • Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. J. Portela, J. Boissier, B. Gourbal, V. Pradines, V. Colliere, F. Cosledan, B. Meunier, A. Robert. PLoS Negl. Trop. Dis., 6, e1474 (2012). Abstract
  • Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bioactive conformations. J-L. Stigliani, V. Bernardes-Genisson, J. Bernadou, G. Pratviel. Org. Biomol. Chem., 10, 6341-6349 (2012. Abstract
  • A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion “G+34” generated by metalloporphyrin/KHSO5 reagent. A. Tomaszewska, S. Mourgues, P. Guga, B. Nawrot, G. Pratviel. Chem. Res. Toxicol., 25, 2505-2512 (2012). Abstract
Patents
  • Thieno[3,2-d]pyrimidin-4(3h)-one derivatives and the preparation and pharmaceutical uses thereof. Cohen A., Azas N., Verhaeghe P., Rault S., Suzanne P., Lancelot J-C., Lesnard A. FR2014/050094; WO 2014111666 (2014)
  • New antiinfective derivatives, methods for their preparation, pharmaceutical compositions containing them, and their therapeutic use Bernadou J., Bernardes-Génisson V., Delaine T., Quémard A. EP2240449; WO2009101345 (2009).