Partenaires

CNRS
Site web Université de Toulouse



Rechercher

Sur ce site

Sur le Web du CNRS


Accueil du site > Equipes > G. PRATVIEL

G. PRATVIEL

Put on-line by Gaëtan Havet, Jean-Luc STIGLIANI

Metals in Biology and Medicinal Chemistry


Metals in Biology and Medicinal Chemistry

Group leader : Geneviève Pratviel - Directeur de Recherche, CNRS


Genevieve Pratviel’s group is focused on the understanding at the molecular level of the processes involving metal ions in biology especially when they are related to health. Currently, team’s projects deal with (i) implication of the redox reactivity of metal ions in the mechanism of action of drugs, (ii) disruption of metal homeostasis leading to oxidative damage and cell dysfunction, and (iii) the structural and functional role of metal ions in proteins and protein models. These projects link fundamental research to applications in biotechnology and drug design in the field of cancer, infectious diseases (tuberculosis, malaria…), and Alzheimer disease.
  • Research Topics
Permanent staff
Dr Geneviève PRATVIEL  
DR
CNRS
+33 5 61 33 31 46
Research topics
Dr Anne ROBERT  
DR
CNRS
+33 5 61 33 31 26
Research topics
Dr Bernard MEUNIER 
Emeritus Director of Research
CNRS
+05 61 33 31 84
CV
Prof. Jean BERNADOU 
Emeritus Professor
Université Paul Sabatier
+33 5 61 33 31 17
Research topics
Prof. Vania BERNARDES-GENISSON
Professor
Université Paul Sabatier
+33 5 61 33 31 50
Research topics
Prof. Pierre VERHAEGHE 
Professor
Université Paul Sabatier
+33 5 61 33 32 36
+33 5 62 25 68 67
Research topics

Dr Céline DERAEVE 
Assistant Professor
Université Paul Sabatier
+33 5 61 33 31 48
Research topics
Dr Colin BONDUELLE 
CR
CNRS
+33 5 61 33 32 36
Research topics
Dr Jean-Luc STIGLIANI 
Assistant Professor, UPS
+33 5 61 33 31 50
Research topics
 Emmanuelle MOTHES 
 Tc, CNRS
+33 5 61 33 31 50

Non-permanent staff
Julie LABORDE 
Doctorante
+33 5 61 33 31 48
Research topics
Aurélien CHOLLET 
Doctorant
+33 5 61 33 31 50
Research topics
Dr Michel NGUYEN 
Engineer
+33 5 61 33 31 26
Research topics


  • Publications since 2009
  • Selected Publications
- Reviews
Schistosomiasis Chemotherapy. S. A.-L. Thetiot-Laurent, J. Boissier, A. Robert, B. Meunier. Angew. Chem. Int. Ed. 52, 7936-7956 (2013)

Isoniazid: an update on the multiple mechanisms for a singular action. V. Bernardes-Genisson, C. Deraeve, A. Chollet, J. Bernadou, G. Pratviel. Curr. Med. Chem. 20, 4370-4385 (2013)

Oxidative Damage Mediated by Transition Metal Ions and Their Complexes. G. Pratviel. Met. Ions Life Sci. 10, 201-216 (2012)

Activation of DNA Carbon-Hydrogen Bonds by Metal Complexes. M. Pitié, G. Pratviel. Chem. Rev. 110, 1018-1059 (2010)

Heme as trigger and target for trioxane-containing antimalarial drugs. B. Meunier, A. Robert. Acc. Chem. Res. 43, 1444-1451 (2010)

- Articles
Interaction of cationic manganese porphyrin with G-quadruplex nucleic acids probed by differential labeling of the two faces of the porphyrin. V. Pradines, G. Pratviel. Angew. Chem. Int. Ed. 52, 2185-2188 (2013)

Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. J. Portela, J. Boissier, B. Gourbal, V. Pradines, V. Collière, F. Coslédan, B. Meunier, A. Robert. PLoS Negl. Trop. Dis. 6, e1474 (2012)

Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bioactive conformations. J-L. Stigliani, V. Bernardes-Génisson, J. Bernadou, G. Pratviel. Org. Biomol. Chem. 10, 6341-6349 (2012)

A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion “G+34” generated by metalloporphyrin/KHSO5 reagent. A. Tomaszewska, S. Mourgues, P. Guga, B. Nawrot, G. Pratviel. Chem. Res. Toxicol. 25, 2505-2512 (2012)

Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as antimycobacterial agents. C. Deraeve, M. Dorobantu, F. Rebbah, F. Le Quemener, P. Constant, A. Quémard, V. Bernardes-Génisson, J. Bernadou, G. Pratvie. Bioorg. Med. Chem. 19, 6225-6232 (2011)

Trioxaferroquines as new hybrid antimalarial drugs. F. Bellot, F. Coslédan, L. Vendier, J. S. Brocard, B. Meunier, A. Robert. J. Med. Chem. 53, 4103-4109 (2010)

Photolysis and thermolysis of platinum(IV) 2,2’-bipyridine complexes lead to identical platinum(II) DNA adducts. C. Loup, A. Tésouro Vallina, Y. Coppel, U. Letinois, Y. Nakabayashi, B. Meunier, B. Lippert, G. Pratviel. Chem. Eur. J. 16, 11420-11431 (2010)

Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents. T. Delaine, V. Bernardes-Génisson, A. Quémard, P. Constant, B. Meunier, J. Bernadou. Eur. J. Med. Chem. 45, 4554-4561 (2010)

Interaction of cationic nickel and manganese porphyrins with the minor groove of DNA. C. Romera, L. Sabater, A. Garofalo, I. M. Dixon, G. Pratviel. Inorg. Chem. 49, 8558-8567 (2010)

In vitro activities of Trioxaquines® 2 against Schistosoma mansoni. J. Boissier, F. Coslédan, A. Robert, B. Meunier. Antimicrob. Agents Chemother. 53, 4903-4906 (2009)