Laboratoire de Chimie de Coordination.
Toulouse,
France

 

The group of Geneviève Pratviel is focused on the understanding at the molecular level of systems involving metal ions in biological systems, especially when development in medicinal chemistry can be expected. The projects are dealing with :
 the role of metal complexes in interaction with DNA and implication in development of antitumor drugs;
 the role of metal ions in the mechanism of action of drugs as a guide to drug design.

Research fields include:

• Biomimetic oxidation catalysts (metalloporphyrins, ...) for fine chemistry and in vitro drug metabolism.
• Mechanism of oxidative damage to DNA.
• Design of artificial nucleases based on metal complexes.
• Dual molecules nuclease-alkylating agent: application to the study of clustered DNA damage and design of antitumoral drugs.
• Targeting quadruplex DNA with metalloporphyrins, telomeres dysfunction and potential anticancer drugs.
• Mechanism of action of artemisinin and related antimalarial/antiparasitic drugs containing a peroxide.
• New drugs against malaria and schistosomiasis.
• Mechanism of action of isoniazid and design of potential antitubercular drugs.
• Cellular targeting and photodynamic therapy. Conjugates of dye with protein vectors.
• Molecular modeling.

• Research Topics

• Permanent staff

• Geneviève PRATVIEL - Directeur de Recherche, CNRS
  +33 5 61 33 31 46
  
  
• Jean BERNADOU - Professeur, Université Paul Sabatier
  +33 5 61 33 31 17
  
  
• Anne ROBERT - Directeur de Recherche, CNRS
  +33 5 61 33 31 26
  
  
• Vania BERNARDES-GENISSON - Professeur, Université Paul Sabatier
  +33 5 61 33 31 50
  
  
• Marguerite PITIE - Chargée de Recherche, CNRS
  +33 5 61 33 32 36
  
  
• Céline DERAEVE - Maître de conférences, Université Paul Sabatier
  +33 5 61 33 31 48
  
  
• Jean-Luc STIGLIANI - Maître de conférences, Université Paul Sabatier
  +33 5 61 33 31 50
  
  
• Emmanuelle MOTHES - Technicienne, CNRS
  +33 5 61 33 31 50
  
  

• Non-permanent staff

• Fatima BOUSEJRA - PhD student
  +33 5 61 33 31 26
  
  
• Irene NICOLAS - Postdoctoral researcher
  +33 5 61 33 31 26
  
  
• Antonio GAROFALO - Postdoctoral researcher
  +33 5 61 33 32 36
  
  
• Vincent PRADINES - Postdoctoral researcher
  +33 5 61 33 31 48
  
  
• Carmen ROMERA - PhD student
  +33 5 61 33 31 48
  
  
• Laurent SABATER - Postdoctoral researcher
  +33 5 61 33 31 48
  
  

• Selected Publications

- Reviews
• The key role of heme to trigger the antimalarial activity of trioxanes. Robert A., Benoit-Vical F., Meunier B. Coord. Chem. Rev., 2005, 249, 1927-1936
• DNA oxidation by copper and manganese complexes. Pitié M., Boldron C., Pratviel G. Adv. Inorg. Chem., 2006, 58, 77-130
• Guanine oxidation: one- and two-electron reactions. Pratviel G., Meunier B. Chem. Eur. J., 2006, 12, 6018-6030

- Articles
• The antimalarial drug artemisinin alkylates heme ininfected mice. Robert A., Benoit-Vical F., Claparols C., Meunier B. Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 13676-13680. Correction: 2006, 103, 3943
• A G-quadruplex ligand with 10000-fold selectivity over duplex DNA. Dixon I. M., Lopez F., Tejera A. M., Estève J.-P., Blasco M. A., Pratviel G., Meunier B. J. Am. Chem. Soc., 2007, 129, 1502-1503
• Synthesis of the isonicotinoylnicotinamide scaffolds of the naturally occurring isoniazid - NAD(P) adducts. Delaine T., Bernardes-Génisson V., Meunier B., Bernadou J. J. Org. Chem., 2007, 72, 675-678
• Binding of the tautomeric forms of isoniazid-NAD adducts to the active site of the Mycobacterium tuberculosis enoyl-ACP reductase (InhA): a theoretical approach. Stigliani J.-L., Arnaud P., Delaine T., Bernardes-Génisson V., Meunier B., Bernadou J. J. Mol. Graphics Modell., 2008, 27, 536-545
• Platined copper(3-Clip-Phen) complexes as effective DNA-cleaving and cytotoxic agents. Ozalp-Yaman S., De Hoog P., Amadei G., Pitié M., Gamez P., Dewelle J., Mijatovic T., Meunier B., Kissel T., Reedjik J. Chem. Eur. J., 2008, 14, 3418-3426