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G. PRATVIEL

Put on-line by Gaëtan Havet, Jean-Luc STIGLIANI

Metals in Biology and Medicinal Chemistry


Metals in Biology and Medicinal Chemistry

Group leader : Geneviève Pratviel - Directeur de Recherche, CNRS


Genevieve Pratviel’s group is focused on the understanding at the molecular level of the processes involving metal ions in biology especially when they are related to health. Currently, team’s projects deal with (i) implication of the redox reactivity of metal ions in the mechanism of action of drugs, (ii) disruption of metal homeostasis leading to oxidative damage and cell dysfunction, and (iii) the structural and functional role of metal ions in proteins and protein models. These projects link fundamental research to applications in biotechnology and drug design in the field of cancer, infectious diseases (tuberculosis, malaria…), and Alzheimer disease.

Cationic manganese porphyrin binds
selectively to G-quadruplex DNA
Long-chain azaisoindolinone
docked inside the active site of InhA,
a key enzyme of M. tuberculosis

- Research Topics

- Job opportunities

Permanent staff
Geneviève PRATVIEL  
Director of Research
CNRS
+33 5 61 33 31 46
CV
Anne ROBERT  
Director of Research
CNRS
+33 5 61 33 31 26
CV
Bernard MEUNIER  
Emeritus Director of Research
CNRS
+33 5 61 33 31 84
CV
Jean BERNADOU 
Emeritus Professor
Université Paul Sabatier
+33 5 61 33 31 17
Research topics
Vania BERNARDES-GENISSON 
Professor
Université Paul Sabatier
+33 5 61 33 31 50
Research topics
Pierre VERHAEGHE 
Professor
Université Paul Sabatier
+33 5 61 33 32 36
+33 5 62 25 68 67
CV

Céline DERAEVE 
Assistant Professor
Université Paul Sabatier
+33 5 61 33 31 48
CV
Colin BONDUELLE 
Research Fellow
CNRS
+33 5 61 33 32 36
CV
Research topics
 Jean-Luc STIGLIANI 
 Assistant Professor
Université Paul Sabatier
+33 5 61 33 31 50
Research topics
 Emmanuelle MOTHES 
 technician, CNRS
+33 5 61 33 31 50

Non-permanent staff
Julie LABORDE 
PhD student
Chemical Engineer ESCOM
+33 5 61 33 31 48
CV
Julien PEDRON 
PhD student
+33 5 61 33 32 36
CV
Cyril FERSING 
PhD student, Pharmacist Intern AP-HM
Co-direction Aix-Marseille University
+33 5 61 33 32 36
CV



- Collaborations

- Publications since 2008

- Recent Publications:

Reviews
  • Porphyrins in complex with DNA: modes of interaction and oxidation reactions. G. Pratviel Coord. Chem. Rev. (2015). Abstract
  • Regulation of copper and iron homeostasis by metal chelators: A possible chemotherapy for Alzheimer’s disease. A. Robert, Y. Liu, M. Nguyen, B. Meunier. Acc. Chem. Res. 48, 1332–1339 (2015). Abstract
  • Schistosomiasis Chemotherapy. S. A.-L. Thetiot-Laurent, J. Boissier, A. Robert, B. Meunier. Angew. Chem. Int. Ed. 52, 7936-7956 (2013). Abstract
  • Isoniazid: an update on the multiple mechanisms for a singular action. V. Bernardes-Genisson, C. Deraeve, A. Chollet, J. Bernadou, G. Pratviel. Curr. Med. Chem., 20, 4370-4385 (2013). Abstract
  • Oxidative Damage Mediated by Transition Metal Ions and Their Complexes. G. PRATVIEL Met. Ions Life Sci. 10 , 201-216 (2012). Abstract

Articles
  • Guanosine in a single stranded region of anticodon stem-loop tRNA models is prone to oxidative damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions A. Tomaszewska-Antczak, P. Guga, B. Nawrot, G. Pratviel Chemistry Eur. J. 21, 6381-6385 (2015) Abstract
  • Crystal Structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach A. Chollet, L. Mourey, C. Lherbet, A. Delbot, S. Julien, M. Baltas, J. Bernadou, G. Pratviel, L. Maveyraud, V. Bernardes-Génisson J. Struct. Biol. 190, 328-337 (2015) Abstract
  • Synthesis, Characterization, and Biological Interaction of Glyconanoparticles with Controlled Branching. W.T. Liau, C. Bonduelle, M. Brochet, S. Lecommandoux, A.M. Kasko Biomacromolecules 16, 284-294 (2015) Abstract
  • Nano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI. A. Hannecart, D. Stanicki, L. Vander Elst, R. N. Muller, S. Lecommandoux, J. Thevenot, C. Bonduelle, A. Trotier, P. Massot, S. Miraux, O. Sandre, S. Laurent Nanoscale 7, 3754-3767 (2015) Abstract
  • Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series C. Kieffer, A. Cohen, P. Verhaeghe, L. Paloque, S. Hutter, C. Castera-Ducros, M. Laget, S. Rault, A. Valentin, P. Rathelot, N. Azas, P. Vanelle. Bioorg. Med. Chem. 23, 2377-2386 (2015) Abstract
  • Cobalt(III)porphyrin to target G-quadruplex DNA L. Sabater, Pei-Ju Fang, Chi-Fon Chang, A. De Rache, E. Prado, J. Dejeu, A. Garofalo, Jung-Hsin Lin, J.-L. Mergny, E. Defrancq, G. Pratviel Dalton Trans. 44, 3701-3707 (2015) Abstract
  • The necessity of having a tetradentate ligand to extract copper(II) ions from amyloids. M. Nguyen, L. Rechignat, A. Robert, B. Meunier. ChemistryOpen 4, 27-31 (2015) Abstract
  • Iminosugar-based glycopolypeptides: glycosidase inhibition with bioinspired glycoprotein analogue micellar self-assemblies. C. Bonduelle, J. Huang, T. Mena-Barragán, C. Ortiz Mellet, C. Decroocq, E. Etamé, A. Heise, P. Compain, S. Lecommandoux Chem. Commun. 50, 3350-3352 (2014) Abstract
  • Concept for simultaneous and specific in situ monitoring of amyloid oligomers and fibrils via FRET B. Alies, H. Eury, E. M. Essassi, G. Pratviel, C. Hureau, P. Faller Anal. Chem. 86, 11877-11882 (2014) Abstract
  • Characterization of New Specific Copper Chelators as Potential Drugs for the Treatment of Alzheimer’s Disease. M. Nguyen, A. Robert, A. Sournia-Saquet, L. Vendier, B. Meunier. Chem. Eur. J., 20, 6771-6785 (2014) Abstract
  • Interaction of cationic manganese porphyrin with G-quadruplex nucleic acids probed by differential labeling of the two faces of the porphyrin. V. Pradines, G. Pratviel. Angew. Chem. Int. Ed. 52, 2185-2188 (2013) Abstract
  • Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug. A. Robert, C. Claparols, B. Witkowski, F. Benoit-Vical. Antimicrob. Agents Ch., 57 (8), 3998-4000 (2013) Abstract
  • Protonation state of trans axial water molecule switches the reactivity of high-valent manganese-oxo porphyrin. J. Trzcionka, J. Irvoas, G. Pratviel New J. Chem., 37, 3581-3590 (2013) Abstract
  • Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. J. Portela, J. Boissier, B. Gourbal, V. Pradines, V. Colliere, F. Cosledan, B. Meunier, A. Robert. PLoS Negl. Trop. Dis., 6, e1474 (2012). Abstract
  • Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bioactive conformations. J-L. Stigliani, V. Bernardes-Genisson, J. Bernadou, G. Pratviel. Org. Biomol. Chem., 10, 6341-6349 (2012. Abstract
  • A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion “G+34” generated by metalloporphyrin/KHSO5 reagent. A. Tomaszewska, S. Mourgues, P. Guga, B. Nawrot, G. Pratviel. Chem. Res. Toxicol., 25, 2505-2512 (2012). Abstract
Patents
  • Thieno[3,2-d]pyrimidin-4(3h)-one derivatives and the preparation and pharmaceutical uses thereof. Cohen A., Azas N., Verhaeghe P., Rault S., Suzanne P., Lancelot J-C., Lesnard A. FR2014/050094; WO 2014111666 (2014)
  • New antiinfective derivatives, methods for their preparation, pharmaceutical compositions containing them, and their therapeutic use Bernadou J., Bernardes-Génisson V., Delaine T., Quémard A. EP2240449; WO2009101345 (2009).