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G. PRATVIEL

Put on-line by Gaëtan Havet, Jean-Luc STIGLIANI

Metals in Biology and Medicinal Chemistry

 

The group of Geneviève Pratviel is focused on the understanding at the molecular level of systems involving metal ions in biological systems, especially when development in medicinal chemistry can be expected. The projects are dealing with :
- the role of metal complexes in interaction with DNA and implication in development of antitumor drugs;
- the role of metal ions in the mechanism of action of drugs as a guide to drug design.

Research fields include:

  • Biomimetic oxidation catalysts (metalloporphyrins, ...) for fine chemistry and in vitro drug metabolism.
  • Mechanism of oxidative damage to DNA.
  • Design of artificial nucleases based on metal complexes.
  • Dual molecules nuclease-alkylating agent: application to the study of clustered DNA damage and design of antitumoral drugs.
  • Targeting quadruplex DNA with metalloporphyrins, telomeres dysfunction and potential anticancer drugs.
  • Mechanism of action of artemisinin and related antimalarial/antiparasitic drugs containing a peroxide.
  • New drugs against malaria and schistosomiasis.
  • Mechanism of action of isoniazid and design of potential antitubercular drugs.
  • Cellular targeting and photodynamic therapy. Conjugates of dye with protein vectors.
  • Molecular modeling.
  • Research Topics
  • Permanent staff
  • Geneviève PRATVIEL - Directeur de Recherche, CNRS
    +33 5 61 33 31 46

  • Anne ROBERT - Directeur de Recherche, CNRS
    +33 5 61 33 31 26

  • Bernard MEUNIER - Directeur de Recherche émérite, CNRS
    CV
    +05 61 33 31 84

  • Jean BERNADOU - Professeur émérite, Université Paul Sabatier
    +33 5 61 33 31 17

  • Vania BERNARDES-GENISSON - Professeur, Université Paul Sabatier
    +33 5 61 33 31 50

  • Pierre VERHAEGHE - Professeur, Université Paul Sabatier
    +33 5 61 33 32 36 - +33 5 62 25 68 67

  • Céline DERAEVE - Maître de conférences, Université Paul Sabatier
    +33 5 61 33 31 48

  • Jean-Luc STIGLIANI - Maître de conférences, Université Paul Sabatier
    +33 5 61 33 31 50

  • Emmanuelle MOTHES - Technicienne, CNRS
    +33 5 61 33 31 50

  • Non-permanent staff
  • Julie LABORDE - PhD student
    +33 5 61 33 31 48

  • Aurélien CHOLLET - PhD student
    +33 5 61 33 31 50

  • Michel NGUYEN - Engineer
    +33 5 61 33 31 26

  • Colin BONDUELLE - Postdoctoral research fellow
    +33 5 61 33 32 36

  • Publications since 2009
  • Selected Publications
- Reviews
Schistosomiasis Chemotherapy. S. A.-L. Thetiot-Laurent, J. Boissier, A. Robert, B. Meunier. Angew. Chem. Int. Ed. 52, 7936-7956 (2013)

Isoniazid: an update on the multiple mechanisms for a singular action. V. Bernardes-Genisson, C. Deraeve, A. Chollet, J. Bernadou, G. Pratviel. Curr. Med. Chem. 20, 4370-4385 (2013)

Oxidative Damage Mediated by Transition Metal Ions and Their Complexes. G. Pratviel. Met. Ions Life Sci. 10, 201-216 (2012)

Activation of DNA Carbon-Hydrogen Bonds by Metal Complexes. M. Pitié, G. Pratviel. Chem. Rev. 110, 1018-1059 (2010)

Heme as trigger and target for trioxane-containing antimalarial drugs. B. Meunier, A. Robert. Acc. Chem. Res. 43, 1444-1451 (2010)

- Articles
Interaction of cationic manganese porphyrin with G-quadruplex nucleic acids probed by differential labeling of the two faces of the porphyrin. V. Pradines, G. Pratviel. Angew. Chem. Int. Ed. 52, 2185-2188 (2013)

Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni. J. Portela, J. Boissier, B. Gourbal, V. Pradines, V. Collière, F. Coslédan, B. Meunier, A. Robert. PLoS Negl. Trop. Dis. 6, e1474 (2012)

Cross-docking study on InhA inhibitors: a combination of Autodock Vina and PM6-DH2 simulations to retrieve bioactive conformations. J-L. Stigliani, V. Bernardes-Génisson, J. Bernadou, G. Pratviel. Org. Biomol. Chem. 10, 6341-6349 (2012)

A single nuclease-resistant linkage in DNA as a versatile tool for the characterization of DNA lesions: application to the guanine oxidative lesion “G+34” generated by metalloporphyrin/KHSO5 reagent. A. Tomaszewska, S. Mourgues, P. Guga, B. Nawrot, G. Pratviel. Chem. Res. Toxicol. 25, 2505-2512 (2012)

Chemical synthesis, biological evaluation and structure-activity relationship analysis of azaisoindolinones, a novel class of direct enoyl-ACP reductase inhibitors as antimycobacterial agents. C. Deraeve, M. Dorobantu, F. Rebbah, F. Le Quemener, P. Constant, A. Quémard, V. Bernardes-Génisson, J. Bernadou, G. Pratvie. Bioorg. Med. Chem. 19, 6225-6232 (2011)

Trioxaferroquines as new hybrid antimalarial drugs. F. Bellot, F. Coslédan, L. Vendier, J. S. Brocard, B. Meunier, A. Robert. J. Med. Chem. 53, 4103-4109 (2010)

Photolysis and thermolysis of platinum(IV) 2,2’-bipyridine complexes lead to identical platinum(II) DNA adducts. C. Loup, A. Tésouro Vallina, Y. Coppel, U. Letinois, Y. Nakabayashi, B. Meunier, B. Lippert, G. Pratviel. Chem. Eur. J. 16, 11420-11431 (2010)

Development of isoniazid-NAD truncated adducts embedding a lipophilic fragment as potential bi-substrate InhA inhibitors and antimycobacterial agents. T. Delaine, V. Bernardes-Génisson, A. Quémard, P. Constant, B. Meunier, J. Bernadou. Eur. J. Med. Chem. 45, 4554-4561 (2010)

Interaction of cationic nickel and manganese porphyrins with the minor groove of DNA. C. Romera, L. Sabater, A. Garofalo, I. M. Dixon, G. Pratviel. Inorg. Chem. 49, 8558-8567 (2010)

In vitro activities of Trioxaquines® 2 against Schistosoma mansoni. J. Boissier, F. Coslédan, A. Robert, B. Meunier. Antimicrob. Agents Chemother. 53, 4903-4906 (2009)