Laboratoire de Chimie de Coordination UPR 8241


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Conférence Dr Ling Peng
Centre Interdisciplinaire de Nanoscience de Marseille

Mercredi 13 Octobre 2021 à 14h30 - Auditorium Fernand Gallais

"Modular and adaptive dendrimer nanosystems for biomedical applications"



The application of nanotechnology is widely expected to bring breakthrough in medicine for disease treatment and diagnosis. Dendrimers are ideal materials for elaborating nanomedicine by virtue of their well-defined structure, multivalent cooperativity and nanosize per se. We will present our recent studies on modular and adaptive dendrimer nanosystems, constructed via self-assembling of amphiphilic dendrimers,1 for the delivery of imaging agents,2 anticancer drugs3 and nucleic acid therapeutics4 in cancer detection and treatment. The self-assembling approach to create supramolecular dendrimer is completely novel in concept yet easy to implement in practice, offering a fresh perspective for exploiting the advantageous features of supramolecular dendrimers in biomedical applications.


1. Acc. Chem. Res. 2020, 53, 2936.
2. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, 11454 ; Small 2020, 16, 2003290 ; Chem. Commun. 2020, 56, 301.
3. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 2978 ; Exploration 2021, DOI : 10.1002/EXP.20210003
4. Nat. Protoc. 2021, 16, 327 ; NanoRes 2021, 14, 2247 ; J. Am. Chem. Soc. 2018, 140, 16264 ; Angew. Chem. Int. Ed. 2014, 53, 11822.