Laboratoire de Chimie de Coordination UPR 8241


Accueil > EQUIPES > Equipe F

Thématiques

Only the general research themes of the group are described below. For a more exhaustive description, please visit the personal page of the group members.

● Theme 1 : Molecular basis of metal ions – amyloids interaction
(persons involved : Christelle Hureau, Fabrice Collin and Béatrice Mestre-Voegtlé)

We study the coordination of Cu(I/II) and Zn(II) with the amyloid-β peptide involved in Alzheimer’s disease and how it could impact the two deleterious processes at the origin of the pathology, i.e. oxidative stress and peptide aggregation. A possible synergetic link between the two processes is also under investigation.

● Theme 2 : Development of new therapeutic approaches
(persons involved : Christelle Hureau, Emmanuel Gras)

Two main strategies are under focus, the first one being centered on the use of chelating compounds to remove Cu from the amyloid-β : chelators targeting either Cu(I) or Cu(II), impact of Zn(II) in Cu detoxification by chelators, bi-functional chelators encompassing an amyloid-β recognition moiety.
The second one relies on the use of natural and artificial chaperones to counter-act the aggregation process. Artificial chaperones include Pt or Ru – based compounds, POM or Ln-complexes.

● Theme 3 : Detection of various species of the aggregation process
(persons involved : Béatrice Mestre-Voegtlé, Emmanuel Gras, Christelle Hureau)

We aim at rationally developing new (in vitro and in vivo) imaging tools to monitor the aggregation process of the amyloid-β peptide and of other amyloidogenic peptides. Two approaches are undertaken : SAR with 2-aryl-benzothiazole derivatives and combinatorial chemistry dynamics to select probes of various stage of the aggregation.
Ln-based MRI agents are also studied in the context of Type-2 diabetes.

The group is also strong implicated in the Team-project BIOMAPS hosted at ITAV.