Laboratoire de Chimie de Coordination UPR 8241

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Barakat, F., Vansteelandt, M., Triastuti, A., Jargeat, P., Jacquemin, D., Graton, J., Mejia, K., Cabanillas, B., Vendier, L., Stigliani, J. - L., Haddad, M., & Fabre, N. (2019). Thiodiketopiperazines with two spirocyclic centers extracted from Botryosphaeria mamane, an endophytic fungus isolated from Bixa orellana L. Phytochemistry, 158, 142–148.
Fersing, C., Basmaciyan, L., Boudot, C., Pedron, J., Hutter, S., Cohen, A., Castera-Ducros, C., Primas, N., Laget, M., Casanova, M., Bourgeade-Delmas, S., Piednoel, M., Sournia-Saquet, A., Belle Mbou, V., Courtioux, B., Boutet-Robinet, E., Since, M., Milne, R., Wyllie, S., Fairlamb, A. H., Valentin, A., Rathelot, P., Verhaeghe, P., Vanelle, P., & Azas, N. (2019). Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines are NTR1 substrates that display potent in vitro antileishmanial activity. Acs Med. Chem. Lett., 10(1), 34–39.


Aujard-Catot, J., Nguyen, M., Bijani, C., Pratviel, G., & Bonduelle, C. (2018). Cd2+ coordination: An efficient structuring switch for polypeptide polymers. Polym. Chem., 9(30), 4100–4107.
Bonduelle, C. (2018). Secondary structures of synthetic polypeptide polymers. Polym. Chem., 9, 1517–1529.
Chollet, A., Maveyraud, L., Lherbet, C., & Bernardes-Genisson, V. (2018). An overview on crystal structures of InhA protein: Apo-form, in complex with its natural ligands and inhibitors. Eur. J. Med. Chem., 146, 318–343.
El-Kashef, H., El-Emary, T., Verhaeghe, P., Vanelle, P., & Samy, M. (2018). Anticancer and anti-inflammatory activities of some new pyrazolo[3,4-b]pyrazines. Molecules, 23(10), 2657.
Fersing, C., Boudot, C., Pedron, J., Hutter, S., Primas, N., Castera-Ducros, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Moreau, A., Cohen, A., Stigliani, J. - L., Pratviel, G., Crozet, M. D., Wyllie, S., Fairlamb, A., Valentin, A., Rathelot, P., Azas, N., Courtioux, B., Verhaeghe, P., & Vanelle, P. (2018). 8-Aryl-6-chloro-3-nitro-2-(phenylsulfonylmethyl)imidazo[1,2-a]pyridines as potent antitrypanosomatid molecules bioactivated by type 1 nitroreductases. Eur. J. Med. Chem., 157, 115–126.
Gumpelmayer, M., Nguyen, M., Molnar, G., Bousseksou, A., Meunier, B., & Robert, A. (2018). Magnetite Fe3O4 has no intrinsic peroxidase activity, and is probably not involved in Alzheimer's oxidative stress. Angew. Chem., Int. Ed., 57, 14758 –14763.
Laborde, J., Deraeve, C., de Mesquita Vieira, F. G., Sournia-Saquet, A., Rechignat, L., Drumond Villela, A., Lopes Abbadi, B., Souza Macchi, F., Pissinati, K., Bizarro, C. V., Machado, P., Augusto Basso, L., Pratviel, G., Gonzaga de França Lopes, L., Silva Sousa, E. H., & Bernardes-Genisson, V. (2018). Synthesis and mechanistic investigation of iron(II) complexes of isoniazid and derivatives as a redox-mediated activation strategy for anti-tuberculosis therapy. J. Inorg. Biochem., 179, 71–81.
Nguyen, M., Stigliani, J. - L., Bijani, C., Verhaeghe, P., Pratviel, G., & Bonduelle, C. (2018). Ionic polypeptide polymers with unusual β-sheet stability. Biomacromolecules, 19(10), 4068–4074.
Paludetto, M. - N., Bijani, C., Puisset, F., Bernardes-Genisson, V., Arellano, C., & Robert, A. (2018). Metalloporphyrin-catalyzed oxidation of sunitinib and pazopanib, two anticancer tyrosine kinase inhibitors: Evidence for new potentially toxic metabolites. J. Med. Chem., 61(17), 7849–7860.
Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P., & Valentin, A. (2018). Antitrypanosomatid pharmacomodulation at position 3 of the 8-nitroquinolin-2(1H)-one scaffold using palladium-catalysed cross-coupling reactions. ChemMedChem, 13(20), 2217–2228.
Pedron, J., Boudot, C., Hutter, S., Bourgeade-Delmas, S., Stigliani, J. - L., Sournia-Saquet, A., Moreau, A., Boutet-Robinet, E., Paloque, L., Mothes, E., Laget, M., Vendier, L., Pratviel, G., Wyllie, S., Fairlamb, A., Azas, N., Courtioux, B., Valentin, A., & Verhaeghe, P. (2018). Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules: Synthesis, electrochemical and SAR study. Eur. J. Med. Chem., 155, 135–152.
Prado, E., Bonnat, L., Bonnet, H., Lavergne, T., Van der Heyden, A., Pratviel, G., Dejeu, J., & Defrancq, E. (2018). Influence of the SPR experimental conditions on the G-quadruplex DNA recognition by porphyrin derivatives. Langmuir, 34(43), 13057–13064.


Desroches, J., Kieffer, C., Primas, N., Hutter, S., Gellis, A., El-Kashef, H., Rathelot, P., Verhaeghe, P., Azas, N., & Vanelle, P. (2017). Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold. Eur. J. Med. Chem., 125, 68–86.
Nguyen, M., Meunier, B., & Robert, A. (2017). Catechol-based ligands as potential metal chelators inhibiting redox activity in Alzheimer's disease. Eur. J. Inorg. Chem., 2017(25), 3198–3204.
Nguyen, M., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Nucleopolypeptides with DNA-triggered a helix-to-b sheet transition. Chem. Commun., 53(54), 7501–7504.
Nguyen, M., Vendier, L., Stigliani, J. - L., Meunier, B., & Robert, A. (2017). Structures of the copper and zinc complexes of PBT2, a chelating agent evaluated as potential drug for neurodegenerative diseases. Eur. J. Inorg. Chem., 2017(3), 600–608.
Piedra-Arroni, E., Makni, F., Severac, L., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Smart poly(imidazoyl-l-lysine): Synthesis and reversible helix-to-coil transition at neutral pH. Polymers, 9(7), 276.
Saint-Germes, L., Bar, L., Dejeu, J., Spinelli, N., Defrancq, E., & Pratviel, G. (2017). The pK(a) value of the proximal water molecule trans to a high-valent Mn-V=O porphyrin: towards the control of reactivity by pH. Dalton Trans., 46(36), 12088–12094.


Bonduelle, C., Makni, F., Severac, L., Piedra-Arroni, E., Serpentini, C. - L., Lecommandoux, S., & Pratviel, G. (2016). Smart metallopoly(l-glutamic acid) polymers: reversible helix-to-coil transition at neutral pH. RSC Advances, 6, 84694–84697.
Bonduelle, C., Oliveira, H., Gauche, C., Huang, J., Heise, A., & Lecommandoux, S. (2016). Multivalent effect of glycopolypeptide based nanoparticles for galectin binding. Chemical Communications, 52, 11251–11254.
Castera-Ducros, C., El-Kashef, H., Piednoel, M., Remusat, V., Teulade, J. - C., Verhaeghe, P., Rathelot, P., & Vanelle, P. (2016). Using the Sonogashira reaction for preparing a new fragment library based on the 3-alkynylimidazo[1,2-a]pyridine scaffold. Letters in Organic Chemistry, 13(7), 519–525.
Chollet, A., Stigliani, J. - L., Pasca, M. R., Mori, G., Lherbet, C., Constant, P., Quemard, A., Bernadou, J., Pratviel, G., & Bernardes-Genisson, V. (2016). Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis. Chemical Biology & Drug Design, 88, 740–755.
Dejeu, J., Lavergne, T., Della Nora, J., Defrancq, E., & Pratviel, G. (2016). Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal. Inorganica Chimica Acta, 452, 98–103.
Gellis, A., Primas, N., Hutter, S., Lanzada, G., Remusat, V., Verhaeghe, P., Vanelle, P., & Azas, N. (2016). Looking for new antiplasmodial quinazolines: DMAP-catalyzed synthesis of 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines and their in vitro evaluation toward Plasmodium falciparum. European Journal of Medicinal Chemistry, 119, 34–44.
Laborde, J., Deraeve, C., Duhayon, C., Pratviel, G., & Bernardes-Genisson, V. (2016). Ethionamide biomimetic activation and an unprecedented mechanism for its conversion into active and non-active metabolites. Org. Biomol. Chem., 14(37), 8848–8858.
Laborde, J., Deraeve, C., Lecoq, L., Sournia-Saquet, A., Stigliani, J. - L., Orena, B. S., Mori, G., Pratviel, G., & Bernardes-Génisson, V. (2016). Synthesis, oxidation potential and anti–mycobacterial activity of isoniazid and analogues: Insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1, 172–179.
Meunier, B. (2016). Age and Alzheimer’s disease. Nutrients, 8, 372.
Perrier, A., Mothes, E., Bonduelle, C., & Pratviel, G. (2016). Synthesis of asymmetric guanidiniumphenyl-aminophenyl porphyrins. Journal of Porphyrins and Phthalocyanines, 20(12), 1438–1443.
Pratviel, G. (2016). Porphyrins in complex with DNA: Modes of interaction and oxidation reactions. Coordination Chemistry Reviews, 308, Part 2, 460–477.
Robert, A. (2016). Le fer de l’hème : cible pour la chimiothérapie du paludisme. Culture Sciences-Chimie, (ressources scientifiques pour les enseignants).
Robert, A., Nguyen, M., & Meunier, B. (2016). Restauration of copper homeostasis for therapy of Alzheimer’s disease. J. Int. Soc. Antioxid. Nutr. Health, 3, 35.


Chollet, A., Mori, G., Menendez, C., Rodriguez, F., Fabing, I., Pasca, M. R., Madacki, J., Kordulakova, J., Constant, P., Quémard, A., Bernardes-Génisson, V., Lherbet, C., & Baltas, M. (2015). Design, synthesis and evaluation of new GEQ derivatives as inhibitors of InhA enzyme and Mycobacterium tuberculosis growth. European Journal of Medicinal Chemistry, 101, 218–235.
Chollet, A., Mourey, L., Lherbet, C., Delbot, A., Julien, S., Baltas, M., Bernadou, J., Pratviel, G., Maveyraud, L., & Bernardes-Genisson, V. (2015). Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. Journal of Structural Biology, 190, 328–337.
Cohen, A., Suzanne, P., Lancelot, J. - C., Verhaeghe, P., Lesnard, A., Basmaciyan, L., Hutter, S., Laget, M., Dumètre, A., Paloque, L., Deharo, E., Crozet, M. D., Rathelot, P., Dallemagne, P., Lorthiois, A., Hopkins Sibley, C., Vanelle, P., Valentin, A., Mazier, D., Rault, S., & Azas, N. (2015). Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium. European Journal of Medicinal Chemistry, 95, 16–28.
Hannecart, A., Stanicki, D., Vander Elst, L., Muller, R. N., Lecommandoux, S., Thevenot, J., Bonduelle, C., Trotier, A., Massot, P., Miraux, S., Sandre, O., & Laurent, S. (2015). Nano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI. Nanoscale, 7(8), 3754–3767.
Kieffer, C., Cohen, A., Verhaeghe, P., Hutter, S., Castera-Ducros, C., Laget, M., Remusat, V., M'Rabet, M. K., Rault, S., Rathelot, P., Azas, N., & Vanelle, P. (2015). Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series. European Journal of Medicinal Chemistry, 92, 282–294.
Kieffer, C., Cohen, A., Verhaeghe, P., Paloque, L., Hutter, S., Castera-Ducros, C., Laget, M., Rault, S., Valentin, A., Rathelot, P., Azas, N., & Vanelle, P. (2015). Antileishmanial pharmacomodulation in 8-nitroquinolin-2(1H)-one series. Bioorg. Med. Chem., 23(10), 2377–2386.
Kieffer, C., Verhaeghe, P., Lagrassa, S., Gregoire, R., Moussaoui, Z., Casteras-Ducros, C., Clark, J. E., Vanelle, P., & Rathelot, P. (2015). Preventing the contamination of hospital personnel by cytotoxic agents: Evaluation and training of the para-professional healthcare workers in oncology units. Eur. J. Cancer Care, 24(3), 404–410.
Liau, W. T., Bonduelle, C., Brochet, M., Lecommandoux, S., & Kasko, A. M. (2015). Synthesis, characterization, and biological interaction of glyconanoparticles with controlled branching. Biomacromolecules, 16(1), 284–294.
McIntosh, J. T., Nazemi, A., Bonduelle, C., Lecommandoux, S., & Gillies, E. R. (2015). Synthesis, self-assembly, and degradation of amphiphilic triblock copolymers with fully photodegradable hydrophobic blocks. Can. J. Chem., 93(1), 126–133.
Meunier, B., & Robert, A. (2015). L’hème : une cible pour la chimiothérapie des parasites hématophages. Actualité Chimique “Dossier La chimie en Région Midi-Pyrénées”, 392, xv.
Nguyen, M., Bijani, C., Martins, N., Meunier, B., & Robert, A. (2015). Transfer of copper from an myloid to a natural copper-carrier peptide with a specific mediating ligand. Chemistry- A European Journal, 21, 17085–17090.
Nguyen, M., Rechignat, L., Robert, A., & Meunier, B. (2015). The necessity of having a tetradentate ligand to extract copper(II) ions from amyloids. ChemistryOpen, 4, 27–31.
Perdigao, G., Deraeve, C., Mori, G., Pasca, M. R., Pratviel, G., & Bernardes-Génisson, V. (2015). Pyridine-3,4-dicarboximide as starting material for the total synthesis of the natural product eupolauramine and its isomer iso-eupolauramine endowed with anti-tubercular activities. Tetrahedron, 71, 1555–1559.
Peyret, A., Trant, J. F., Bonduelle, C. V., Ferji, K., Jain, N., Lecommandoux, S., & Gillies, E. R. (2015). Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids. Polymer Chemistry, 6, 7902–7912.
Pradines, V., Bijani, C., Stigliani, J. - L., Blanzat, M., Rico-Lattes, I., & Pratviel, G. (2015). Cationic porphyrin – anionic surfactant mixtures for the promotion of self-organized 1:4 ion pair in water with strong aggregation properties. ChemPhysChem, 16(18), 3877–3885.
Robert, A., Liu, Y., Nguyen, M., & Meunier, B. (2015). Regulation of copper and iron homeostasis by metal chelators: A possible chemotherapy for Alzheimer’s disease. Accounts of Chemical Research, 48, 1332–1339.
Sabater, L., Fang, P. - J., Chang, C. - F., De Rache, A., Prado, E., Dejeu, J., Garofalo, A., Lin, J. - H., Mergny, J. - L., Defrancq, E., & Pratviel, G. (2015). Cobalt(iii)porphyrin to target G-quadruplex DNA. Dalton Transactions, 44, 3701–3707.