Laboratoire de Chimie de Coordination UPR 8241

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Desroches, J., Kieffer, C., Primas, N., Hutter, S., Gellis, A., El-Kashef, H., Rathelot, P., Verhaeghe, P., Azas, N., & Vanelle, P. (2017). Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold. Eur. J. Med. Chem., 125, 68–86.
Nguyen, M., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Nucleopolypeptides with DNA-triggered a helix-to-b sheet transition. Chem. Commun., 53(54), 7501–7504.
Nguyen, M., Vendier, L., Stigliani, J. - L., Meunier, B., & Robert, A. (2017). Structures of the copper and zinc complexes of PBT2, a chelating agent evaluated as potential drug for neurodegenerative diseases. Eur. J. Inorg. Chem., 2017(3), 600–608.
Piedra-Arroni, E., Makni, F., Severac, L., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Smart poly(imidazoyl-l-lysine): Synthesis and reversible helix-to-coil transition at neutral pH. Polymers, 9(7), 276.


Bonduelle, C., Makni, F., Severac, L., Piedra-Arroni, E., Serpentini, C. - L., Lecommandoux, S., & Pratviel, G. (2016). Smart metallopoly(l-glutamic acid) polymers: reversible helix-to-coil transition at neutral pH. RSC Advances, 6, 84694–84697.
Bonduelle, C., Oliveira, H., Gauche, C., Huang, J., Heise, A., & Lecommandoux, S. (2016). Multivalent effect of glycopolypeptide based nanoparticles for galectin binding. Chemical Communications, 52, 11251–11254.
Castera-Ducros, C., El-Kashef, H., Piednoel, M., Remusat, V., Teulade, J. - C., Verhaeghe, P., Rathelot, P., & Vanelle, P. (2016). Using the Sonogashira reaction for preparing a new fragment library based on the 3-alkynylimidazo[1,2-a]pyridine scaffold. Letters in Organic Chemistry, 13(7), 519–525.
Chollet, A., Stigliani, J. L., Pasca, M. R., Mori, G., Lherbet, C., Constant, P., Quemard, A., Bernadou, J., Pratviel, G., & Bernardes-Genisson, V. (2016). Evaluation of the inhibitory activity of (aza)isoindolinone-type compounds: toward in vitro InhA action, Mycobacterium tuberculosis growth and mycolic acid biosynthesis. Chemical Biology & Drug Design, 88, 740–755.
Dejeu, J., Lavergne, T., Della Nora, J., Defrancq, E., & Pratviel, G. (2016). Binding of metalloporphyrins to G-quadruplex DNA: The role of the central metal. Inorganica Chimica Acta, 452, 98–103.
Gellis, A., Primas, N., Hutter, S., Lanzada, G., Remusat, V., Verhaeghe, P., Vanelle, P., & Azas, N. (2016). Looking for new antiplasmodial quinazolines: DMAP-catalyzed synthesis of 4-benzyloxy- and 4-aryloxy-2-trichloromethylquinazolines and their in vitro evaluation toward Plasmodium falciparum. European Journal of Medicinal Chemistry, 119, 34–44.
Laborde, J., Deraeve, C., Duhayon, C., Pratviel, G., & Bernardes-Genisson, V. (2016). Ethionamide biomimetic activation and an unprecedented mechanism for its conversion into active and non-active metabolites. Organic & Biomolecular Chemistry, 14, 8848–8858.
Laborde, J., Deraeve, C., Lecoq, L., Sournia-Saquet, A., Stigliani, J. - L., Orena, B. S., Mori, G., Pratviel, G., & Bernardes-Génisson, V. (2016). Synthesis, oxidation potential and anti–mycobacterial activity of isoniazid and analogues: Insights into the molecular isoniazid activation mechanism. ChemistrySelect, 1, 172–179.
Perrier, A., Mothes, E., Bonduelle, C., & Pratviel, G. (2016). Synthesis of asymmetric guanidiniumphenyl-aminophenyl porphyrins. Journal of Porphyrins and Phthalocyanines, 20(12), 1438–1443.
Pratviel, G. (2016). Porphyrins in complex with DNA: Modes of interaction and oxidation reactions. Coordination Chemistry Reviews, 308, Part 2, 460–477.
Robert, A. (2016). Le fer de l’hème : cible pour la chimiothérapie du paludisme. Culture Sciences-Chimie, (ressources scientifiques pour les enseignants).


Chollet, A., Mourey, L., Lherbet, C., Delbot, A., Julien, S., Baltas, M., Bernadou, J., Pratviel, G., Maveyraud, L., & Bernardes-Genisson, V. (2015). Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach. Journal of Structural Biology, 190, 328–337.
Cohen, A., Suzanne, P., Lancelot, J. - C., Verhaeghe, P., Lesnard, A., Basmaciyan, L., Hutter, S., Laget, M., Dumètre, A., Paloque, L., Deharo, E., Crozet, M. D., Rathelot, P., Dallemagne, P., Lorthiois, A., et al. (2015). Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium. European Journal of Medicinal Chemistry, 95, 16–28.
Kieffer, C., Cohen, A., Verhaeghe, P., Hutter, S., Castera-Ducros, C., Laget, M., Remusat, V., M'Rabet, M. K., Rault, S., Rathelot, P., Azas, N., & Vanelle, P. (2015). Looking for new antileishmanial derivatives in 8-nitroquinolin-2(1H)-one series. European Journal of Medicinal Chemistry, 92, 282–294.
Meunier, B., & Robert, A. (2015). L’hème : une cible pour la chimiothérapie des parasites hématophages. Actualité Chimique “Dossier La chimie en Région Midi-Pyrénées”, 392, xv.
Nguyen, M., Bijani, C., Martins, N., Meunier, B., & Robert, A. (2015). Transfer of copper from an myloid to a natural copper-carrier peptide with a specific mediating ligand. Chemistry- A European Journal, 21, 17085–17090.
Nguyen, M., Rechignat, L., Robert, A., & Meunier, B. (2015). The necessity of having a tetradentate ligand to extract copper(II) ions from amyloids. ChemistryOpen, 4, 27–31.
Perdigao, G., Deraeve, C., Mori, G., Pasca, M. R., Pratviel, G., & Bernardes-Génisson, V. (2015). Pyridine-3,4-dicarboximide as starting material for the total synthesis of the natural product eupolauramine and its isomer iso-eupolauramine endowed with anti-tubercular activities. Tetrahedron, 71, 1555–1559.
Peyret, A., Trant, J. F., Bonduelle, C. V., Ferji, K., Jain, N., Lecommandoux, S., & Gillies, E. R. (2015). Synthetic glycopolypeptides: synthesis and self-assembly of poly(γ-benzyl-l-glutamate)-glycosylated dendron hybrids. Polymer Chemistry, 6, 7902–7912.
Robert, A., Liu, Y., Nguyen, M., & Meunier, B. (2015). Regulation of copper and iron homeostasis by metal chelators: A possible chemotherapy for Alzheimer’s disease. Accounts of Chemical Research, 48, 1332–1339.
Sabater, L., Fang, P. - J., Chang, C. - F., De Rache, A., Prado, E., Dejeu, J., Garofalo, A., Lin, J. - H., Mergny, J. - L., Defrancq, E., & Pratviel, G. (2015). Cobalt(iii)porphyrin to target G-quadruplex DNA. Dalton Transactions, 44, 3701–3707.
Tomaszewska-Antczak, A., Guga, P., Nawrot, B., & Pratviel, G. (2015). Guanosine in a single stranded region of anticodon stem–loop tRNA models is prone to oxidatively generated damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions. Chemistry- A European Journal, 21, 6381–6385.


Alies, B., Eury, H., Essassi, E. M., Pratviel, G., Hureau, C., & Faller, P. (2014). Concept for simultaneous and specific in situ monitoring of amyloid oligomers and fibrils via Förster resonance energy transfer. Analytical Chemistry, 86, 11877–11882.
El Hage, S., Lajoie, B., Stigliani, J. - L., Furiga-Chusseau, A., Roques, C., & Baziard, G. (2014). Synthesis, antimicrobial activity and physico-chemical properties of some n-alkyldimethylbenzylammonium halides. Journal of Applied Biomedicine, 12, 245–253.
Gellis, A., Kieffer, C., Primas, N., Lanzada, G., Giorgi, M., Verhaeghe, P., & Vanelle, P. (2014). A new DMAP-catalyzed and microwave-assisted approach for introducing heteroarylamino substituents at position-4 of the quinazoline ring. Tetrahedron, 70, 8257–8266.
Irvoas, J., Trzcionka, J., & Pratviel, G. (2014). Formation of the carboxamidine precursor of cyanuric acid from guanine oxidative lesion dehydro-guanidinohydantoin. Bioorganic & Medicinal Chemistry, 22, 4711–4716.
Nguyen, M., Robert, A., Sournia-Saquet, A., Vendier, L., & Meunier, B. (2014). Characterization of new specific copper chelators as potential drugs for the treatment of Alzheimer’s disease. Chemistry- A European Journal, 20, 6771–6785.
Primas, N., Suzanne, P., Verhaeghe, P., Hutter, S., Kieffer, C., Laget, M., Cohen, A., Broggi, J., Lancelot, J. - C., Lesnard, A., Dallemagne, P., Rathelot, P., Rault, S., Vanelle, P., & Azas, N. (2014). Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents. European Journal of Medicinal Chemistry, 83, 26–35.
Zanzoul, A., Ramli, Y., Essassi, E. M., & Pratviel, G. (2014). A benzimidazopyridoquinoxaline as promising scaffold for G-quadruplex DNA targeting. Medicinal Chemistry Research, 23, 4042–4049.


Bernardes-Genisson, V., Deraeve, C., Chollet, A., Bernadou, J., & Pratviel, G. (2013). Isoniazid: an update on the multiple mechanisms for a singular action. Current Medicinal Chemistry, 20, 4370–4385.
Boubetra, D., Sabaou, N., Zitouni, A., Bijani, C., Lebrihi, A., & Mathieu, F. (2013). Taxonomy and chemical characterization of new antibiotics produced by Saccharothrix SA198 isolated from a Saharan soil. Microbiological Research, 168, 223–230.
Fainerman, V. B., Mucic, N., Pradines, V., Aksenenko, E. V., & Miller, R. (2013). Adsorption of alkyltrimethylammonium bromides at water/alkane interfaces: Competitive adsorption of alkanes and surfactants. Langmuir, 29, 13783–13789.
Nicolas, I., Bijani, C., Brasseur, D., Pratviel, G., Bernadou, J., & Robert, A. (2013). Metalloporphyrin-catalyzed hydroxylation of the N,N-dimethylamide function of the drug molecule SSR180575 to a stable N-methyl-N-carbinolamide. Comptes Rendus Chimie, 16, 1002–1007.
Pradines, V., & Pratviel, G. (2013). Interaction of cationic manganese porphyrin with G-quadruplex nucleic acids probed by differential labeling of the two faces of the porphyrin. Angewandte Chemie, International Edition, 52, 2185–2188.
Robert, A., Claparols, C., Witkowski, B., & Benoit-Vical, F. (2013). Correlation between Plasmodium yoelii nigeriensis susceptibility to Artemisinin and alkylation of heme by the drug. Antimicrobial Agents and Chemotherapy, 57, 3998–4000.
Thétiot-Laurent, S. A. L., Boissier, J., Robert, A., & Meunier, B. (2013). Schistosomiasis chemotherapy. Angewandte Chemie, International Edition, 52, 7936–7956.
Trzcionka, J., Irvoas, J., & Pratviel, G. (2013). The protonation state of trans axial water molecule switches: the reactivity of high-valent manganese-oxo porphyrin. New Journal of Chemistry, 37, 3581–3590.
Zanzoul, A., El Essassi, M., Pratviel, G., Saadi, M., & El Ammari, L. (2013). N'-(3-Sulfanylidene-3,4-dihydroquinoxalin-2-yl)benzohydrazide dimethylformamide monosolvate. Acta Crystallographica Section E: Structure Reports Online, 69, o1268.


Aouiche, A., Sabaou, N., Meklat, A., Zitouni, A., Bijani, C., Mathieu, F., & Lebrihi, A. (2012). Saccharothrix sp PAL54, a new chloramphenicol-producing strain isolated from a Saharan soil. World Journal of Microbiology & Biotechnology, 28, 943–951.
Azrague, K., Pradines, V., Bonnefille, E., Claparols, C., Maurette, M. T., & Benoit-Marquie, F. (2012). Degradation of 2,4-dihydroxibenzoic acid by vacuum UV process in aqueous solution: Kinetic, identification of intermediates and reaction pathway. Journal of Hazardous Materials, 237-238, 71–78.
Benzeid, H., Mothes, E., Essassi, E. M., Faller, P., & Pratviel, G. (2012). A thienoquinoxaline and a styryl-quinoxaline as new fluorescent probes for amyloid-β fibrils. Comptes Rendus Chimie, 15, 79–85.
Boissier, J., Portela, J., Pradines, V., Coslédan, F., Robert, A., & Meunier, B. (2012). Activity of trioxaquine PA1259 in mice infected by Schistosoma mansoni. Comptes Rendus Chimie, 15, 75–78.
Ceccom, J., Cosledan, F., Halley, H., Frances, B., Lassalle, J. M., & Meunier, B. (2012). Copper chelator induced efficient episodic memory recovery in a non-transgenic Alzheimer's mouse model. Plos One, 7, e43105.
Delaine, T., Bernardes-Génisson, V., Quémard, A., Constant, P., Cosledan, F., Meunier, B., & Bernadou, J. (2012). Preliminary investigations of the effect of lipophilic analogues of the active metabolite of isoniazid toward bacterial and plasmodial strains. Chemical Biology & Drug Design, 79, 1001–1006.
Deraeve, C., Guo, Z., Bon, R. S., Blankenfeldt, W., DiLucrezia, R., Wolf, A., Menninger, S., Stigter, E. A., Wetzel, S., Choidas, A., Alexandrov, K., Waldmann, H., Goody, R. S., & Wu, Y. - W. (2012). Psoromic acid is a selective and covalent rab-prenylation inhibitor targeting autoinhibited RabGGTase. Journal of the American Chemical Society, 134, 7384–7391.
Duburs, G., Neibecker, D., & Zarkovic, N. (2012). Chemistry and personalized medicine – the research and development future of Europe. Croatian Medical Journal, 53, 291–293.