Laboratoire de Chimie de Coordination UPR 8241

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Alzheimer and amyloids : molecular basis, chelation therapy and detection

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The research group : « ALZheimer and AmylOIDs : molecular basis, chelation therapy and detection » is interested on the impact of metallic ions, mainly copper and zinc, in the amyloid cascade linked to Alzheimer disease and in other physio-pathological processes involving amyloidogenic peptides.

Three main axes are under focus :

(i) Understanding at a molecular level of the impact of metallic ions on the aggregation properties of the peptides, i.e. on the self-assembly into β-sheet rich structures (fibrils), and on the oxidative stress. These two phenomena are indeed linked to the etiology of Alzheimer’s disease.

(ii) Developing new concepts based on copper removal from the peptides aiming at reducing their deleterious impacts (linked to oxidative stress and peptide aggregation). Several approaches are considered : copper transport from the extra- to the intra-cellular medium, interference of zinc in copper detoxification, pro-chelator activated by oxidative stress…

(iii) Synthesis and studies of new detection tools for the amyloids, showing selectivity versus the various morphologies of the aggregates and relying on B-F compounds and dynamic combinatorial chemistry.

In addition, a new axis aiming at using the amyloid fibrils as a biocompatible support for catalysis is currently emerging in the team as well as a topic on the oxidation of biomolecules (peptides, membranes) and their study by mass spectrometry.