Laboratoire de Chimie de Coordination UPR 8241


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PNG
Béatrice MESTRE-VOEGTLE

Assistant Professor

Alzoid Group Member
BIOMAPS Group Member and Co-Supervisor

  • Alzoid (Alzheimer and Amyloid) Group Laboratoire de Chimie de Coordination, CNRS UPR8241 BP44099, 205 route de Narbonne, 31077 Toulouse cedex 4, France Office : +33 (0)5 61 33 31 20 E-mail : beatrice.mestre chez lcc-toulouse.fr
  • BIOMAPS Group Institut des Technologies Avancées en sciences du Vivant, CNRS USR3505 1 Place Pierre Potier, 31000 Toulouse Office : +33 (0)5 82 99 10 42 E-Mail : beatrice.mestre chez itav.fr

Education
PhD Chemistry of Biomolecules, University Paul Sabatier, Toulouse, 1996
DEA Chemistry of Biomolecules, University Paul Sabatier, Toulouse, 1993

Professional employments
Assistant Professor, University Paul Sabatier, CNRS-LCC UPR8241, Toulouse, since 2015
Assistant Professor, University Paul Sabatier, LSPCMIB UMR5068, Toulouse, 2005-2014
Assistant Professor, University Victor Segalen, INSERM U-386, Bordeaux, 1998-2002
Post-Doctoral Fellow, University Paris-Sud, CNRS URA 1384, Orsay, 1998
Post-doctoral Fellow, Medical Research Council, LMB-PNAS, Cambridge, UK, 1997

Research Activity
Chemistry of biomolecules, bioorganic and bioionorganic chemistries for fundamental and applied biological studies.

Research Theme 1 : Amyloid Peptide Synthesis and Conjugation
In order to get relevant molecular tools for the studies of amyloid aggregation process, the synthesis of amyloid peptides and their conjugation to small molecular reporters, constitute a fundamental axis of our group’s activity. It comprises the challenging Solid Phase Peptide Synthesis of amyloidogenic biopolymers such as Amyloid-Beta, Amylin and SEM peptides. Their conjugation to probes as well as their immobilization on biochips are also considered.

Research Theme 2 : Rational and Combinatorial Conception of Molecular Scaffolds for the Targeting of the Amyloids
A large part of our project relies on the conception of new compounds able to interact with high affinity and specificity with amyloid aggregates. Such species with optical, paramagnetic or nuclear properties are studied in view of getting new efficient tools for the study of the amyloid aggregation mechanism and for the early detection of amyloid related pathologies. Two approaches are under consideration to design original compounds : (i) the rational synthesis of hybrid molecules able concomitantly to target the aggregates and to highlight such assemblies ; (ii) the selection from dynamic combinatorial libraries of scaffolds with fitted properties for efficient interaction with the aggregates and associated probe’s abilities.

Grants

  • Fondation Plan Alzheimer 2016-2018, PI. Dynamic Combinatorial Synthesis of Optical Molecular Markers of the Aggregated Amyloid-Beta Peptide.
  • ANR DIVA 2016-2021, Partner (PI Dr E Toth, Orleans). Diabetes Imaging by Visualizing Amylin with Metal-based Probes.
  • ANR BoBo 2012-2016, Partner (PI Dr E Gras, Toulouse). Boranes et Composés Boroniques Cationiques : Nouveaux Outils pour la Fluoration et la Radiofluoration.

Collaborations

  • Dr. S. Chassaing, Institut des Technologies Avancées en sciences du Vivant, Toulouse.
  • Pr. C. Gros, Institut de Chimie Moléculaire de l’Université de Bourgogne, Dijon.
  • Dr. C. Di Primo, Institut Européen de Chimie Biologie, Pessac.
  • Dr. E. Toth, Centre de Biophysique Moléculaire, Orléans.