Laboratoire de Chimie de Coordination UPR 8241

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CNRS

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Emmanuel GRAS
CR
0561333156
B121

Presentation


After initial training in General and Organic Chemistry at the University of Orleans, I finally graduated from the Université of Paris Orsay in 1997. Then, I engaged in a PhD program at Orsay funded by the french government and carried out my research at the I.C.S.N. in Gif-sur-Yvette under the joint supervision of Claude Thal and Catherine Guillou. Our work was dedicated to the synthesis of Amaryllidaceae Alkaloids from the Galanthamine family. The formation of the quaternary carbon of these alkaloids was investigated following different paths (i) spirocyclisation of biaryl phenate; (ii) the use of hypervalent iodine for oxidative spirocyclisation and (iii) Heck cyclisation.
Following this PhD, I moved to the University of Oxford to explore in the group of Prof. David M. Hodgson the chemistry of lithiated epoxides with the support of a Marie Curie Fellowship. We more specifically focused our attention on finding ways to avoid the "facile" rearrangement of medium ring lithiated epoxide through a CH insertion in a carbenoid type chemistry. We established a way to generate and trap the lithiated epoxide allowing to access chiral oxiranes from meso compounds.
Following this two years in the UK, I moved back to France after being given a CNRS position in Toulouse where the story continues… (see below!)

Publications


2017

Gras, E., & Chassaing, S. (2017). Carbenes and Nitrenes. In A. C. Knipe (Ed.), (pp. 227–265). Organic Reaction Mechanisms-2014: An annual survey covering the literature dated january to december. Chichester: John Wiley & Sons.
Kuleshova, O., Khilya, O., Volovenko, Y., Mallet-Ladeira, S., Dyakonenko, V., & Gras, E. (2017). Expedited route to fully substituted amino-pyrazole building blocks and their further transformations. ACS Omega, 2(12), 8911–8927.
Perrio, C., Schmitt, S., Pla, D., Gabbai, F. P., Chansaenpak, K., Mestre-Voegtle, B., & Gras, E. (2017). [18F]-Fluoride capture and release: azeotropic drying free nucleophilic aromatic radiofluorination assisted by a phosphonium borane. Chem. Commun., 53(2), 340–343.
Zhu, C., Gras, E., Duhayon, C., Lacassin, F., Cui, X., & Chauvin, R. (2017). The forgotten nitroaromatic phosphines as weakly donating P-ligands: An N-aryl-benzimidazolyl series in RhCl(CO) complexes. Chem. – Asian J., 12(21), 2845–2856.

2016

Gras, E., & Chassaing, S. (2016). Carbenes and Nitrenes. In A. C. Knipe (Ed.), (pp. 177–215). Organic Reaction Mechanisms-2013: An annual survey covering the literature dated january to december. Chichester: John Wiley & Sons.
Hoarau, M., Hureau, C., Gras, E., & Faller, P. (2016). Coordination complexes and biomolecules: A wise wedding for catalysis upgrade. Coordination Chemistry Reviews, 308, Part 2, 445–459.
Hoarau, M., Malbert, Y., Irague, R., Hureau, C., Faller, P., Gras, E., Andre, I., & Remaud-Simeon, M. (2016). A robust and efficient production and purification procedure of recombinant Alzheimers Disease methionine-modified amyloid-β peptides. Plos One, 11(8), e0161209.

2015

Gras, E., & Chassaing, S. (2015). Carbenes and Nitrenes. In A. C. Knipe (Ed.), (pp. 171–208). Organic Reaction Mechanisms-2012: An annual survey covering the literature dated january to december. Chichester: John Wiley & Sons.
Pla, D., Sadek, O., Cadet, S., Mestre-Voegtle, B., & Gras, E. (2015). Naphthylaminoborane: from structural switches to frustrated Lewis pair reactivity. Dalton Transactions, 44, 18340–18346.
Rodriguez-Rodriguez, M., Gras, E., Pericas, M. A., & Gomez, M. (2015). Metal-free intermolecular azide-alkyne cycloaddition promoted by glycerol. Chemistry- A European Journal, 21, 18706–18710.