LCC CNRS

Charlène Esmieu – 32 years old
LCC - UPR 8241
205 Route de Narbonne - 31077 Toulouse - Cedex 04 - France
Tel : +33 561 333 143 charlene.esmieu chez lcc-toulouse.fr

Education

2014 PhD in inorganic and bio-inorganic chemistry – Laboratory of Chemistry and Biology of Metals – UMR 5249 – CEA-CNRS-UGA, Grenoble – France
2011 Master’s degree (bio-organic & bio-inorganic chemistry) – Joseph Fourier University – Grenoble – France

Positions

Since October 2019
CNRS researcher in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse (headed by Dr. Christelle Hureau)
“Syntheses and studies of fluorescent Cu-targeting drugs in Alzheimer disease context”
2018 - 2019
Post-doctoral PRESTIGE Fellow and Marie Curie Fellow in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse with Dr. Christelle Hureau
“Studies of Cu-chelators and Effect of the N-truncation of Aβ peptides on the ROS production by their copper complexes in the context of Alzheimer disease”
2015 - 2018
Post-doctoral Fellow (Wenner-Gren Foundation) in the “bio-physical and bio-inorganic chemistry” Group – Department of Chemistry, Ångström Laboratory – Uppsala University – Sweden with Dr. Gustav Berggren
“Design and preparation of artificial hydrogenases - chemistry and biology in synergy”
2014
PhD in inorganic and bio-inorganic chemistry
Laboratory of Chemistry and Biology of Metals, UMR 5249 – CEA-CNRS-UGA, Grenoble – France
Supervisors : Dr. Stéphane Ménage and Dr. Stéphane Torelli
“Structure-activity relationships in copper complexes bio-inspired from nitrous oxide reductase”

Publications

Author of 15 articles published in international peer-reviewed journals ; Average impact factor (IF) = 9.4, 10 as first author ; 2 Energy Environ. Sci., 2 Angew. Chem. Int. Ed., 2 Chem. Sci., 1 Chem. Eur. J., 1 Sustainable Energy Fuels, 3 Inorg. Chem., and 4 Dalton trans.

Communications

14 oral communications in national and international conferences including 1 Inorganic Reaction Mechanisms & Inorganic Biochemistry Discussion Group Meeting, Manchester, UK, 2019, 1 Young researcher lecture, EuroBIC 13, Budapest, Hungary, 2016, 2 Swedish Consortium for Artificial Photosynthesis, Uppsala University, Sweden, 2016/2017

8 poster presentations in national and international conferences

Awards

• 2019 Best poster award at JCC2019
• 2018 PRESTIGE co-financing grant award (Marie Curie FP7)
• 2016 Travel grant (EuroBIC’13) from the Wenner-Gren Foundation (https://www.swgc.org)
• 2016 Two-years postdoctoral scholarship from the Wenner-Gren Foundation (https://www.swgc.org)
• 2015 Poster selected for a flash poster presentation at ISF-1 (International Solar Fuels Conference)
• 2013 Best poster award at ICBIC’16 (International Conference on Bio-Inorganic Chemistry)
• 2013 PhD Best Publication Award of the Chemistry-Biology Department, Grenoble University

Main research topics

My main focus in the team is to develop and synthesize new fluorescent ligands able to prevent the Cu-Aβ-associated toxicity and ultimately rebalance Cu between intra- and extracellular compartments, and to gain fundamental knowledge about key molecular processes in AD context for therapeutic purposes.