Laboratoire de Chimie de Coordination UPR 8241


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Charlene ESMIEU
CR
0561333120
G167

Présentation


Charlène Esmieu – 33 years old
LCC - UPR 8241
205 Route de Narbonne - 31077 Toulouse - Cedex 04 - France
Tel : +33 561 333 143 charlene.esmieu chez lcc-toulouse.fr

Education

2014 PhD in inorganic and bio-inorganic chemistry – Laboratory of Chemistry and Biology of Metals – UMR 5249 – CEA-CNRS-UGA, Grenoble – France
2011 Master’s degree (bio-organic & bio-inorganic chemistry) – Joseph Fourier University – Grenoble – France

Positions

Since October 2019
CNRS researcher in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse (headed by Dr. Christelle Hureau)
Syntheses and studies of fluorescent Cu-targeting drugs in Alzheimer disease context
2018 - 2019
Post-doctoral PRESTIGE Fellow and Marie Curie Fellow in the “Alzheimer and amyloids” Group – Coordination Chemistry Laboratory (LCC) – UPR CNRS 8241, Toulouse with Dr. Christelle Hureau
Studies of Cu-chelators and Effect of the N-truncation of Aβ peptides on the ROS production by their copper complexes in the context of Alzheimer disease
2015 - 2018
Post-doctoral Fellow (Wenner-Gren Foundation) in the “bio-physical and bio-inorganic chemistry” Group – Department of Chemistry, Ångström Laboratory – Uppsala University – Sweden with Dr. Gustav Berggren
Design and preparation of artificial hydrogenases - chemistry and biology in synergy
2014
PhD in inorganic and bio-inorganic chemistry
Laboratory of Chemistry and Biology of Metals, UMR 5249 – CEA-CNRS-UGA, Grenoble – France
Supervisors : Dr. Stéphane Ménage and Dr. Stéphane Torelli
Structure-activity relationships in copper complexes bio-inspired from nitrous oxide reductase

Publications

Author of 21 articles published in international peer-reviewed journals ; Average impact factor (IF) = 9.4, 10 as first author ; 2 Energy Environ. Sci., 2 Angew. Chem. Int. Ed., 2 Chem. Sci., 1 Chem. Eur. J., 1 Sustainable Energy Fuels, 3 Inorg. Chem., and 4 Dalton trans.

Communications

14 oral communications in national and international conferences including 1 Inorganic Reaction Mechanisms & Inorganic Biochemistry Discussion Group Meeting, Manchester, UK, 2019, 1 Young researcher lecture, EuroBIC 13, Budapest, Hungary, 2016, 2 Swedish Consortium for Artificial Photosynthesis, Uppsala University, Sweden, 2016/2017

8 poster presentations in national and international conferences

Awards

• 2020 ANR JCC "Copperation"
• 2019 Best poster award at JCC2019
• 2018 PRESTIGE co-financing grant award (Marie Curie FP7)
• 2016 Travel grant (EuroBIC’13) from the Wenner-Gren Foundation (https://www.swgc.org)
• 2016 Two-years postdoctoral scholarship from the Wenner-Gren Foundation (https://www.swgc.org)
• 2015 Poster selected for a flash poster presentation at ISF-1 (International Solar Fuels Conference)
• 2013 Best poster award at ICBIC’16 (International Conference on Bio-Inorganic Chemistry)
• 2013 PhD Best Publication Award of the Chemistry-Biology Department, Grenoble University

Main research topics

My main focus in the team is to develop and synthesize new fluorescent ligands able to prevent the Cu-Aβ-associated toxicity and ultimately rebalance Cu between intra- and extracellular compartments, and to gain fundamental knowledge about key molecular processes in AD context for therapeutic purposes.

Publications


2021

Berthonnaud, L., Esmieu, C., Mallet-Ladeira, S., & Hureau, C. (2021). Solid-state and solution characterizations of [(TMPA)Cu(II)(SO3)] and [(TMPA)Cu(II)(S2O3)] complexes: Application to sulfite and thiosulfate fast detection. J. Inorg. Biochem., 225, 111601/1–9.
Beuning, C. N., Zocchi, L. J., Malikidogo, K. P., Esmieu, C., Dorlet, P., Crans, D. C., & Hureau, C. (2021). Measurement of interpeptidic CuII exchange rate constants of CuII-Amyloid-β complexes to small peptide motifs by tryptophan fluorescence quenching. Inorg. Chem., 60(11), 7650–7659.
Drommi, M., Rulmont, C., Esmieu, C., & Hureau, C. (2021). Hybrid bis-histidine phenanthroline-based ligands to lessen Aβ-bound Cu ROS production: An illustration of Cu(I) significance. Molecules, 26(24), 7630/1–15.
Esmieu, C., Balderrama-Martínez-Sotomayor, R., Conte-Daban, A., Iranzo, O., & Hureau, C. (2021). Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps. Inorg. Chem., 60(2), 1248–1256.
Esmieu, C., Ferrand, G., Borghesani, V., & Hureau, C. (2021). Impact of N-truncated Aβ peptides on Cu- and Cu(Aβ)-generated ROS: CuI matters. Chem. – Eur. J., 27(5), 1777–1786.
Queyriaux, N., Esmieu, C., Gupta, A. K., Vendier, L., Ott, S., Orio, M., & Hammarström, L. (2021). Electrochemical, spectroscopic, and computational investigation of a series of polypyridyl ruthenium(II) complexes: Characterization of reduced states. Eur. J. Inorg. Chem., 2021(13), 1263–1270.

2019

Esmieu, C., Guettas, D., Conte-Daban, A., Sabater, L., Faller, P., & Hureau, C. (2019). Copper-targeting approaches in alzheimer’s disease: how to improve the fallouts obtained from in vitro studies. Inorg. Chem., 58(20), 13509–13527.