Laboratoire de Chimie de Coordination UPR 8241




Natural proteins are linear macromolecules constituted of amino acids that have the ability to fold into highly organized structures. These nanometric assemblies are crucial and they are at the origin of the essential functions of life. Synthetic polypeptides polymers are simplified proteins analogues that are made of blocks of amino acids. They are perfect materials 1) to design protein mimics able to reproduce some properties of natural proteins, 2) to create innovative polymeric structures for materials science applications. In particular, polypeptide polymers can adopt natural protein secondary structures such as alpha-helix or beta-sheets and this unique feature is, in polymer chemistry, at the origin of intriguing physico-chemical properties. In this context, the use of coordination chemistry as a way to tune the physico-chemistry of synthetic polypeptides polymers has been poorly explored, even if coordination chemistry represents nowadays an important tool to design advanced materials with enhanced properties. I want to show that thanks to reversible coordination chemistry, synthetic polypeptides polymers can behave as metal responsive polymeric systems. The aim of this current work is the design of new smart metallopolypeptide that will find uses in (bio)diagnosis and in catalysis.



Aujard-Catot, J., Nguyen, M., Bijani, C., Pratviel, G., & Bonduelle, C. (2018). Cd2+ coordination: An efficient structuring switch for polypeptide polymers. Polym. Chem., 9(30), 4100–4107.
Bonduelle, C. (2018). Secondary structures of synthetic polypeptide polymers. Polym. Chem., 9, 1517–1529.
Nguyen, M., Stigliani, J. - L., Bijani, C., Verhaeghe, P., Pratviel, G., & Bonduelle, C. (2018). Ionic polypeptide polymers with unusual β-sheet stability. Biomacromolecules, 19(10), 4068–4074.
Pedron, J., Boudot, C., Bourgeade-Delmas, S., Sournia-Saquet, A., Paloque, L., Rastegari, M., Abdoulaye, M., El-Kashef, H., Bonduelle, C., Pratviel, G., Wyllie, S., Fairlamb, A. H., Courtioux, B., Verhaeghe, P., & Valentin, A. (2018). Antitrypanosomatid pharmacomodulation at position 3 of the 8-nitroquinolin-2(1H)-one scaffold using palladium-catalysed cross-coupling reactions. ChemMedChem, 13(20), 2217–2228.


Nguyen, M., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Nucleopolypeptides with DNA-triggered a helix-to-b sheet transition. Chem. Commun., 53(54), 7501–7504.
Piedra-Arroni, E., Makni, F., Severac, L., Stigliani, J. - L., Pratviel, G., & Bonduelle, C. (2017). Smart poly(imidazoyl-l-lysine): Synthesis and reversible helix-to-coil transition at neutral pH. Polymers, 9(7), 276.


Bonduelle, C., Makni, F., Severac, L., Piedra-Arroni, E., Serpentini, C. - L., Lecommandoux, S., & Pratviel, G. (2016). Smart metallopoly(l-glutamic acid) polymers: reversible helix-to-coil transition at neutral pH. RSC Advances, 6, 84694–84697.
Bonduelle, C., Oliveira, H., Gauche, C., Huang, J., Heise, A., & Lecommandoux, S. (2016). Multivalent effect of glycopolypeptide based nanoparticles for galectin binding. Chemical Communications, 52, 11251–11254.
Perrier, A., Mothes, E., Bonduelle, C., & Pratviel, G. (2016). Synthesis of asymmetric guanidiniumphenyl-aminophenyl porphyrins. Journal of Porphyrins and Phthalocyanines, 20(12), 1438–1443.


Hannecart, A., Stanicki, D., Vander Elst, L., Muller, R. N., Lecommandoux, S., Thevenot, J., Bonduelle, C., Trotier, A., Massot, P., Miraux, S., Sandre, O., & Laurent, S. (2015). Nano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI. Nanoscale, 7(8), 3754–3767.