Archives des Themes team M - LCC CNRS Toulouse https://www.lcc-toulouse.fr/en/category/themes-team-m/ Laboratoire Chimie Coordination CNRS Toulouse Thu, 30 Oct 2025 11:35:06 +0000 en-GB hourly 1 https://wordpress.org/?v=7.0.2 https://www.lcc-toulouse.fr/wp-content/uploads/2021/09/cropped-logo_lcc_carre-32x32.png Archives des Themes team M - LCC CNRS Toulouse https://www.lcc-toulouse.fr/en/category/themes-team-m/ 32 32 Phosphorus dendrimers https://www.lcc-toulouse.fr/en/organometallic-chemistry-and-catalysis-via-dendrimers/ Wed, 14 Dec 2022 18:28:14 +0000 https://www.lcc-toulouse.fr/?p=7145 Since 1993, the team has developed a recognized expertise in the synthesis of phosphorus dendritic architectures.

L’article Phosphorus dendrimers est apparu en premier sur LCC CNRS Toulouse.

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Phosphorus dendrimers

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Phosphorus dendrimers

Since 1993, the team has developed a recognized expertise in the synthesis of phosphorus dendritic architectures. The diversity and richness of phosphorus chemistry enable the design of dendrimer, dendron, or Janus dendrimer macromolecules, characterized by perfectly defined structures and original physicochemical properties. The applications of these objects are explored in various fields, notably catalysis, materials, and health.

Dendrimers and Catalysis

Phosphorus dendrimers functionalized with transition metal complexes at their periphery, core, or within the branches are investigated as catalysts for various types of reactions. The use of dendritic catalysts offers several advantages, including facilitated recovery and recycling, and, in some cases, a positive dendritic effect, resulting in improved catalytic activity with increasing dendrimer size. The possibility of designing bifunctional dendrimers also paves the way for their use in tandem catalysis. Furthermore, the use of phosphorus dendrimer-based catalysts in organocatalysis, phase-transfer catalysis, and catalysis in unconventional media is also investigated.

Dendrimers and Materials

The team develops materials integrating phosphorus dendrimers, such as nanostructured hybrid materials or materials functionalized on their surface with dendrimers. Sensors, nanotubes, and DNA chips with improved-performance have been obtained. The incorporation of phosphorus dendrimers bearing donor and/or acceptor chromophores at their periphery into photovoltaic cells is also being explored.

Dendrimers and Health

The team develops phosphorus dendrimers and dendrons specifically functionalized to endow them with biological properties, or designed to encapsulate biologically active molecules within their cavities. Among the targeted activities are anticancer, anti-infectious, and anti-inflammatory properties, the latter being studied by the start-up IMD-Pharma. The development of dendrimers as fluorescent probes or for applications in two-photon absorption-induced phototherapy are also part of the research directions being pursued.

LCC

Laboratoire de chimie de coordination du CNRS

205 route de Narbonne, BP 44099
31077 Toulouse cedex 4
France

+ 33 5 61 33 31 00

Contact

L’article Phosphorus dendrimers est apparu en premier sur LCC CNRS Toulouse.

]]> Small therapeutic molecules https://www.lcc-toulouse.fr/en/nanomaterials-based-on-dendrimers/ Wed, 14 Dec 2022 18:26:34 +0000 https://www.lcc-toulouse.fr/?p=7147 In recent years, the team has broadened its scope of activities and is developing projects focused on the design of small molecules with biological activity.

L’article Small therapeutic molecules est apparu en premier sur LCC CNRS Toulouse.

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Small therapeutic molecules

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Small therapeutic molecules

In recent years, the team has broadened its scope of activities and is developing projects focused on the design of small molecules with biological activity. Two main research directions are being explored: on the one hand, the development of targeted protein degradation strategies through PROTACs for cancer treatment, and on the other hand, the synthesis of unsaturated small molecules, lipidic or not, to evaluate their therapeutic potential, particularly for anticancer and anti-infectious applications. The start-up B Molecular, issued from the team’s activities, develops specific molecular tools for capturing proteins for therapeutic purposes.

PROTAC and AUTOTAC

The development of chimeric molecules targeting proteolysis via the proteasome pathway (PROTAC) or autophagy (AUTOTAC) allows understanding the role of key factors in the development of multiple pathologies, including several types of cancer. The current objective of the team’s research in this direction is to improve the first PROTACs and AUTOTACs obtained, with the aim of applying them in the treatment of mantle cell lymphoma and pancreatic cancer, in collaboration with the Cancer Research Center of Toulouse (CRCT) and the Joseph Carreras Leukaemia Research Institute in Barcelona.

Unsaturated molecules

Unsaturated small molecules are designed to evaluate their therapeutic properties: on the one hand, bioinspired lipidic molecules are developed to assess their anticancer and anti-infectious activity; on the other hand, hybrid pro-drug molecules combining two bioactive unsaturated fragments are elaborated and investigated for their antitubercular properties.

LCC

Laboratoire de chimie de coordination du CNRS

205 route de Narbonne, BP 44099
31077 Toulouse cedex 4
France

+ 33 5 61 33 31 00

Contact

L’article Small therapeutic molecules est apparu en premier sur LCC CNRS Toulouse.

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