Study published in RSC Mechanochemistry

One of the main challenges facing research into the synthesis of biologically active molecules, including medicines, is the development of more environmentally-friendly methods. Under the term ‘green chemistry’, issues of efficiency, waste management and energy consumption are addressed in this research.

Mechanochemistry, which enables a chemical reaction to be induced by the direct input of mechanical energy, provides a partial response to this challenge. In this context, chemists from the CNRS (Laboratoire de chimie de coordination (LCC – CNRS) and “Institut des sciences analytiques et de physico-chimie pour l’environnement et les matériaux” (IPREM – CNRS/Université de Pau Pays de l’Adour)) have revisited a very important reaction in medicinal chemistry: the Biginelli reaction.

These results, published in the journal RSC Mechanochemistry, open the way to new sustainable strategies for the synthesis of therapeutic molecules and other active compounds.

• Read the full post (in french) on the website of the CNRS Institute of Chemistry (INC) – Editor: Anne-Valerie RUZETTE