Conférence Pr Frederik R. Wurm
Pr Frederik R. Wurm
Sustainable Polymer Chemistry, Department of Molecules and Materials, MESA+ Institute for Nanotechnology, Faculty of Science and Technology, University of Twente, P.O. Box 217, Enschede 7500 AE, The Netherlands.
Email: frederik.wurm@utwente.nl
Biodegradable Polyphosphoesters: From Biomedical Imaging to Agrochemical Delivery
PPEs are typically synthesized via ring-opening polymerization (ROP) of cyclic monomers, offering precise control over molecular weight, dispersity, and end-group functionality. This versatility in synthesis allows for the design of polymers with tailored properties, such as degradability, hydrophilicity, and biocompatibility. Our group has extensively explored the synthesis of novel PPEs, including those incorporating bioactive moieties and those designed for specific applications such as drug delivery and tissue engineering. One of our key areas of research has focused on the development of PPEs for biomedical imaging using 31P MRI. The inherent phosphorus centers in the polymer backbone allows for magnetic resonance imaging (MRI).
General Structure of a polyphosphoester and chemical versatility.
In this presentation, I will introduce our recent work on asymmetric copper and silver catalysis using chiral prolinol–phosphine ligands, including analysis by DFT calculations to acquire knowledge on the reaction pathways.1 In particular, I will discuss in detail a copper-catalyzed asymmetric aldol reaction employing sterically demanding dialkyl ketones as electrophiles.2 Insights obtained from DFT calculations were fed back into ligand design, leading to the development of a catalyst system that proceeds with high yields and excellent stereoselectivity.
Beyond biomedical applications, PPEs show promise in controlled release formulations for agrochemicals. By encapsulating pesticides or fertilizers within PPE matrices, we can achieve sustained release, minimizing environmental impact. Our research has explored the use of PPEs to encapsulate and deliver agrochemicals, such as fungicides, into vesicular and highly porous structures demonstrating controlled release profiles and enhanced efficacy.
In summary, polyphosphoesters represent a promising class of biodegradable polymers with a wide range of applications. Our research has demonstrated the versatility of PPEs in various fields, from biomedical imaging to agrochemical delivery. Continued research and development in this area will pave the way for the creation of innovative and sustainable solutions in healthcare, agriculture, and other critical sectors.