Conférence Pr Eva Hevia

Pr Eva HEVIA

Department of Chemistry and Biochemistry, University of Bern

Conférence Team SMAc

Exploiting Chemical Cooperativity for Arene Functionalisation

Recent advances in main group metal chemistry have established cooperative bimetallic reagents, prepared by combining two different s-block metals with distinct polarising powers as a versatile family of organometallic reagents capable of delivering new chemistry irreproducible by either of their single- metal components. Here we present our findings on exploring the reactivity of these heterobimetallic systems for regioselective functionalization of aromatic molecules focusing on metal/halogen¹ and metal/hydrogen² exchanges. Extending bimetallic cooperativity to the sustainable transition metals Fe and Co, this talk will describe new synthetic strategies to promote direct ferration and cobaltation reactions³ as well as providing mechanistic insights on Ni-catalyzed cross couplings of organolithium reagents.⁴

References

1. (a) Bole, L. J.; Judge, N. R.; Hevia, E. Chem. Int. Ed. 2021, 60, 7626. (b) Bole, L. J; Hevia, E. Nat. Synth. 2022, 1, 195.
2. (a) Bole, L. J.; Tortajada, A.; Hevia, E.; Chem. Int. Ed. 2022, 61, e202204262. (b) Kremsmair, A.; Sunagatullina, A. S.; Bole, L. J.; Mastropierro, P.; Graßl, S.; Wilke, H. R.; Godineau, E.; Hevia, E.; Knochel, Angew. Chem. Int. Ed. 2022, 61, e202210491
3. (a) Maddock, L. C. H.; Mu, M.; Garcia-Melchor, M.; Hevia, E. Chem. Int. Ed. 2021, 60, 15296. (b) Logallo, A.; Mu, M.; Garcia-Melchor, M.; Hevia, E. Angew. Chem. Int. Ed. 2022, early view.
4. (a) Borys, A. M.; Hevia, E.; Chem. Int. Ed. 2021, 60, 24659. (b) Borys, A. M.; Malaespina, L.; Grabowsky, S.; Hevia, E.; Angew. Chem. Int. Ed. 2022, 61, e202209797.