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Alzheimer et amyloïdes, chimie bio-inorganique (équipe F)
logo équipe F

LCC

Activités de l’équipe

L’équipe ALAMBIC s’intéresse aux rôles des ions métalliques dans le vivant. La thématique principale concerne le rôle des ions cuivre et zinc dans la maladie d’Alzheimer et dans d’autres processus faisant intervenir des peptides formant des amyloïdes.

Trois axes sont développés :

(i) Une compréhension fine à l’échelle moléculaire des interactions entre les ions métalliques et les peptides;
(ii) La proposition de nouveaux concepts de chélation afin de minimiser les effets néfastes du cuivre;
(iii) La conception de nouvelles sondes des amyloïdes et de leur formation.

Par ailleurs, une thématique émergente dans l’équipe concerne la conception d’enzymes artificielles à lanthanides.

Membres de l’équipe

TousResponsablePermanentsNon-permanents
DR1 CNRS – Responsable d’équipe

HUREAU Christelle

Etudiante Licence

BLANC Camille

Doctorante

BRISON Adèle

Master 2

CAILLAT Antoine

DE CREMOUX Lucie
Doctorante

DE CREMOUX Lucie

Doctorante

DROMMI Marielle

Chargée de Recherche CNRS

ESMIEU Charlène

CDD

FALCONE Enrico

Etudiant

FONDER Alexandre

GARNIER Maritie
ITA

GARNIER Maritie

Master 2

LANTIGNER Lielou

Doctorante

LEFEVRE Margot

Invitée

MARINHO-BARBOSA Barbara

Master 2

MASSOT Mélanie

Chargée de Recherche CNRS

MATHIEU Emilie

Directrice de recherche DR2 CNRS

PRATVIEL Geneviève

Doctorant

RULMONT Clément

Doctorant

SCHMITT David

Aucun résultat trouvé

DR1 CNRS – Responsable d’équipe

HUREAU Christelle

ORCID : 0000-0003-3339-0239
CV (Fichier PDF)

C. Hureau finished her PhD in 2003 in Orsay, on Mn-based structural models of the water-oxidizing centre. Then she made three post-docs at the frontier of (bio-)chemistry, advanced spectroscopy and electrochemistry. In 2007, she joined the LCC where she became group leader of “Alzheimer, amyloids and Bio-Inorganic Chemistry” in 2015. Her works focus on role of metal ions in amyloid diseases and on the design of new drugs. See https://hureaulab.wixsite.com/equipeflcc/christelle-hureau-1

Email:christelle.hureau(at)lcc-toulouse.fr

Téléphone:05.61.33.31.62

Bureau:B101

Equipe:F

Etudiante Licence

BLANC Camille

Email:camille.blanc(at)lcc-toulouse.fr

Téléphone:05.61.33.31.43

Bureau:B113

Equipe:F

Doctorante

BRISON Adèle

Email:adele.brison(at)lcc-toulouse.fr

Téléphone:05.61.33.31.46

Bureau:G171

Equipe:F

Master 2

CAILLAT Antoine

Email:antoine.caillat(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

Doctorante

DE CREMOUX Lucie

Email:lucie.decremoux(at)lcc-toulouse.fr

Téléphone:05.61.33.31.43

Bureau:B113

Equipe:F

Doctorante

DROMMI Marielle

Projet de these : “Design, synthèse et étude de métallopeptidases artificielles dans le contexte de la maladie d’Alzheimer » – sous la supervision des Drs. Christelle Hureau et Charlène Esmieu.

Vous pouvez trouver mon CV sur https://hureaulab.wixsite.com/equipeflcc/marielle-drommi

Email:marielle.drommi(at)lcc-toulouse.fr

Téléphone:05.61.33.31.20

Bureau:G167

Equipe:F

Chargée de Recherche CNRS

ESMIEU Charlène

Email: charlene.esmieu(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

CDD

FALCONE Enrico

Email:enrico.falcone(at)lcc-toulouse.fr

Téléphone:05.61.33.31.43

Bureau:B113

Equipe:F

Etudiant

FONDER Alexandre

Email:alexandre.fonder(at)lcc-toulouse.fr

Téléphone:05.61.33.31.43

Bureau:B113

Equipe:F

ITA

GARNIER Maritie

Email:maritie.garnier(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

Master 2

LANTIGNER Lielou

Email:lielou.lantigner(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

Doctorante

LEFEVRE Margot

Diplômée d’un Master Recherche en chimie des biomolécules de la Faculté des Sciences de Montpellier en 2021, Margot a intégré le Laboratoire de Chimie de Coordination et l’équipe de Christelle Hureau en Janvier 2021 pour son stage de fin d’étude. Actuellement en doctorat dans la même équipe, sous la supervision de Charlène Esmieu, l’objectif de son projet de recherche vise à synthétiser des ligands hybrides, comprenant une séquence peptidique capable de retirer le cuivre(II) de Cu-Aβ et d’arrêter la production d’ERO associée et un synthon organique capable de chelater le zinc et/ou le manganèse afin de pouvoir agir en tant que pro-drogue. Le projet proposé comprend des phases de : (i) synthèse organique et peptidique afin de préparer les nouveaux ligands, (ii) caractérisation physico-chimique (détermination de l’affinité, de la sélectivité, des potentiels redox par UV-vis, fluorescence, RPE, électrochimie) des complexes métalliques (Cu, Zn et Mn) formés à partir de ces ligands, (iii) étude de la capacité des ligands à relarguer le Zn et Mn et à extraire le Cu de Cu-Aβ, (iv) une phase d’étude de l’atténuation de la production d’ERO par ces ligands. Ces études seront réalisées in vitro et in vivo.

Email:margot.lefevre(at)lcc-toulouse.fr

Téléphone:05.61.33.31.20

Bureau:G167

Equipe:F

Invitée

MARINHO-BARBOSA Barbara

Email:barbara.marinho-barbosa(at)lcc-toulouse.fr

Bureau:B103

Equipe:F

Master 2

MASSOT Mélanie

Email:melanie.massot(at)lcc-toulouse.fr

Téléphone:05.61.33.31.43

Bureau:B113

Equipe:F

Chargée de Recherche CNRS

MATHIEU Emilie

Numéro ORCID : 0000-0002-9313-8679

Emilie Mathieu completed her PhD in 2017 at the Laboratoire des Biomolécules from the Ecole Normale Supérieure in Paris (France), working under the supervision of Clotilde Policar and Nicolas Delsuc. Her work focused on the design of superoxide dismutase mimics (SODm) and on linking the biological activity of SODm with their becoming in cells (speciation, location, accumulation). Then, she joined the group of Eszter Borbas at Uppsala University (Sweden) in which she studied photo-induced electron transfer in luminescent lanthanide (Eu, Yb) complexes, with the aim of providing insights in how to design bright luminescent probes. In 2020, she integrated the ALAMBIC team led by Christelle Hureau as a postdoctoral fellow, before obtaining a permanent position as a Chargée de recherche in the team in 2021. Her current work focus on the design of artificial lanthanide enzymes as mimics of the recently discovered lanthanide methanol dehydrogenases

Email:emilie.mathieu(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

Directrice de recherche DR2 CNRS

PRATVIEL Geneviève

 

Email:genevieve.pratviel(at)lcc-toulouse.fr

Téléphone:05.61.33.31.46

Bureau:G171

Equipe:F

Doctorant

RULMONT Clément

Email:clement.rulmont(at)lcc-toulouse.fr

Téléphone:05.61.33.32.48

Bureau:B103

Equipe:F

Doctorant

SCHMITT David

Email:david.schmitt(at)lcc-toulouse.fr

Téléphone:05.61.33.31.46

Bureau:G171

Equipe:F

Thèmes de recherche

Actualités de l’équipe

Publications

2024

Synthesis of nitrostyrylthiazolidine-2,4-dione derivatives displaying antileishmanial potential
Khoumeri O., Hutter S., Primas N., Castera-Ducros C., Carvalho S., Wyllie S., Efrit M. L., Fayolle D., Since M., Vanelle P., Verhaeghe P., Azas N., El-Kashef H.
Pharmaceuticals 2024, 17(7), 878/1-23.
https://doi.org/10.3390/ph17070878
https://hal.science/hal-04635068

Synthesis of new 5- or 7-substituted 3-nitroimidazo[1,2-a]pyridine derivatives using SNAr and palladium-catalyzed reactions to explore antiparasitic structure–activity relationships
Paoli-Lombardo R., Primas N., Bourgeade-Delmas S., Sournia-Saquet A., Castera-Ducros C., Jacquet I., Verhaeghe P., Rathelot P., Vanelle P.
Synthesis 2024, 56(8), 1297-1308.
http://doi.org/10.1055/a-2232-8113
https://hal.science/hal-04503326

Target fishing reveals PfPYK-1 and PfRab6 as potential targets of an antiplasmodial 4-anilino-2-trichloromethylquinazoline hit compound
Kieffer C., Primas N., Hutter S., Merckx A., Reininger L., Bach S., Ruchaud S., Gaillard F., Laget M., Amrane D., Hervé L., Castera-Ducros C., Renault J., Dumètre A., Rault S., Doerig C., Rathelot P., Vanelle P., Azas N., Verhaeghe P.
Bioorganic & Medicinal Chemistry 2024, 102, 117654/1-11.
https://doi.org/10.1016/j.bmc.2024.117654
https://hal.science/hal-04503278

2023

Effect of metal environment and immobilization on the catalytic activity of a Cu superoxide dismutase mimic
Richezzi M., Ferreyra J., Signorella S., Palopoli C., Terrestre G., Pellegri N., Hureau C., Signorella S. R.
Inorganics 2023, 11(11), 425/1-19.
https://doi.org/10.3390/inorganics11110425
https://hal.science/hal-04301970

Synthesis, characterization, and biological properties of the copper(II) complexes with novel ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide
Rusnac R., Garbuz O., Chumakov Y., Tsapkov V., Hureau C., Istrati D., Gulea A.
Inorganics 2023, 11(10), 408/1-17.
https://doi.org/10.3390/inorganics11100408
https://hal.science/hal-04302011

Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship
Lefèvre M., Lantigner L., Andolfo L., Vanucci-Bacqué C., Benoist E., Esmieu C., Bedos-Belval F., Hureau C.
Comptes Rendus Chimie 2023, 26(S3), 1-11.
https://doi.org/10.5802/crchim.255
https://hal.science/hal-04299723

Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability
Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Casanova M., Franetich J.-F., Tajeri S., Malzert-Fréon A., Corvaisier S., Since M., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
European Journal of Medicinal Chemistry 2023, 261, 115873/1-12.
https://doi.org/10.1016/j.ejmech.2023.115873
https://hal.science/hal-04503282

LPMO-like activity of bioinspired copper complexes: from model substrate to extended polysaccharides
Leblay R., Delgadillo-Ruiz R., Decroos C., Hureau C., Réglier M., Castillo Pérez I., Faure B., Simaan A. J.
ChemCatChem 2023, 15(23), e202300933/1-9.
https://doi.org/10.1002/cctc.202300933
https://hal.science/hal-04231361

Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes
Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Renciuk D., Mergny J.-L., Fojta M.
Electrochimica Acta 2023, 442, 141878/1-8.
https://doi.org/10.1016/j.electacta.2023.141878
https://hal.science/hal-04232807

Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides
Falcone E., Hureau C.
Chemical Society Reviews 2023, 52(19), 6595-6600.
http://dx.doi.org/10.1039/D3CS00443K
https://hal.science/hal-04231237

Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer’s disease?
Hureau C.
eBioMedicine 2023, 87, 104403/1-2.
https://doi.org/10.1016/j.ebiom.2022.104403
https://hal.science/hal-04231411

The critical role of ligand flexibility on the activity of free and immobilized Mn superoxide dismutase mimics
Richezzi M., Signorella S., Palopoli C., Pellegri N., Hureau C., Signorella S. R.
Inorganics 2023, 11(9), 359/1-22.
https://doi.org/10.3390/inorganics11090359
https://hal.science/hal-04231291

Biomimetic catalysis of nitrite reductase enzyme using copper complexes in chemical and electrochemical reduction of nitrite
Ferreira M. P., Castro C. B., Honorato J., He S.-Y., Gonçalves Guimarães Júnior W., Esmieu C., Castellano E. E., de Moura A. F., Truzzi D. R., Nascimento O. R., Simonneau A., Marques Netto C. G. C.
Dalton Transactions 2023, 52(32), 11254-11264.
http://dx.doi.org/10.1039/D3DT01091K
https://hal.science/hal-04197074

Oxidative damages on the Alzheimer’s related-Aβ peptide alters its ability to assemble
Cheignon C., Collin F., Sabater L., Hureau C.
Antioxidants 2023, 12(2), 472/1-20.
https://doi.org/10.3390/antiox12020472
https://hal.science/hal-03988839

Ability of azathiacyclen ligands to stop Cu(Aβ)-induced production of reactive oxygen species: [3N1S] is the right donor set
Malikidogo K. P., Drommi M., Atrián-Blasco E., Hormann J., Kulak N., Esmieu C., Hureau C.
Chemistry – A European Journal 2023, 29(14), e202203667/1-11.
https://doi.org/10.1002/chem.202203667
https://hal.archives-ouvertes.fr/hal-03931017

New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability
Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Casanova M., Franetich J.-F., Tajeri S., Malzert-Fréon A., Corvaisier S., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
European Journal of Medicinal Chemistry 2023, 249, 115115/1-12.
https://doi.org/10.1016/j.ejmech.2023.115115
https://hal.science/hal-04503268

2022

Improved emission of Yb(iii) ions in triazacyclononane-based macrocyclic ligands compared to cyclen-based ones
Kiraev S. R., Mathieu E., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
Dalton Transactions 2022, 51(43), 16596-16604.
http://dx.doi.org/10.1039/D2DT02266D
https://hal.science/hal-04297267

Sensitization pathways in NIR-emitting Yb(III) complexes bearing 0, +1, +2, or +3 charges
Mathieu E., Kiraev S. R., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
Journal of the American Chemical Society 2022, 144(46), 21056-21067.
https://doi.org/10.1021/jacs.2c05813
https://hal.science/hal-04297298

Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Amrane S., Jaubert C., Bedrat A., Rundstadler T., Recordon-Pinson P., Aknin C., Guédin A., De Rache A., Bartolucci L., Diene I., Lemoine F., Gascuel O., Pratviel G., Mergny J.-L., Andreola M.-L.
Nucleic Acids Research 2022, 50(21), 12328-12343.
https://doi.org/10.1093/nar/gkac1030
https://hal.science/hal-03874577

Sequence–activity relationship of ATCUN peptides in the context of Alzheimer’s disease
Lefèvre M., Malikidogo K. P., Esmieu C., Hureau C.
Molecules 2022, 27(22), 7903/1-17.
https://doi.org/10.3390/molecules27227903
https://hal.archives-ouvertes.fr/hal-03875481

Effect of N-alkylation in N-carboxyanhydride (NCA) ring-opening polymerization kinetics
Salas-Ambrosio P., Tronnet A., Badreldin M., Ji S., Lecommandoux S., Harrisson S., Verhaeghe P., Bonduelle C.
Polymer Chemistry 2022, 13, 6149-6161.
http://dx.doi.org/10.1039/D2PY00985D
https://hal.archives-ouvertes.fr/hal-03813069

Synthesis, structure, and biologic activity of some copper, nickel, cobalt, and zinc complexes with 2-formylpyridine N4-allylthiosemicarbazone
Graur V., Chumakov Y., Garbuz O., Hureau C., Tsapkov V., Gulea A.
Bioinorganic Chemistry and Applications 2022, 2022, 2705332/1-18.
https://doi.org/10.1155/2022/2705332
https://hal.archives-ouvertes.fr/hal-03807954

Why the Ala-His-His peptide is an appropriate scaffold to remove and redox silence copper ions from the Alzheimer’s-related Aβ peptide
Gonzalez P., Sabater L., Mathieu E., Faller P., Hureau C.
Biomolecules 2022, 12(10), 1327/1-14.
https://doi.org/10.3390/biom12101327
https://hal.archives-ouvertes.fr/hal-03799992

Improving aqueous solubility and in vitro pharmacokinetic properties of the 3-nitroimidazo[1,2-a]pyridine antileishmanial pharmacophore
Paoli-Lombardo R., Primas N., Bourgeade-Delmas S., Hutter S., Sournia-Saquet A., Boudot C., Brenot E., Castera-Ducros C., Corvaisier S., Since M., Malzert-Fréon A., Courtioux B., Valentin A., Verhaeghe P., Azas N., Rathelot P., Vanelle P.
Pharmaceuticals 2022, 15(8), 998/1-26.
https://doi.org/10.3390/ph15080998
https://hal.archives-ouvertes.fr/hal-03755519

Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis
Le N.-H., Constant P., Tranier S., Nahoum V., Guillet V., Maveyraud L., Daffé M., Mourey L., Verhaeghe P., Marrakchi H.
Bioorganic & Medicinal Chemistry 2022, 71116938/1-7.
https://doi.org/10.1016/j.bmc.2022.116938
https://hal.archives-ouvertes.fr/hal-03758907

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy
Mustière R., Lagardère P., Hutter S., Dell’Orco V., Amanzougaghene N., Tajeri S., Franetich J.-F., Corvaisier S., Since M., Malzert-Fréon A., Masurier N., Lisowski V., Verhaeghe P., Mazier D., Azas N., Vanelle P., Primas N.
European Journal of Medicinal Chemistry 2022, 241, 114619/1-13.
https://doi.org/10.1016/j.ejmech.2022.114619
https://hal.archives-ouvertes.fr/hal-03737417

4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives
Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Franetich J.-F., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
Pharmaceuticals 2022, 15(7), 820/1-18.
https://doi.org/10.3390/ph15070820
https://hal.archives-ouvertes.fr/hal-03725749

Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation
Mustière R., Lagardère P., Hutter S., Deraeve C., Schwalen F., Amrane D., Masurier N., Azas N., Lisowski V., Verhaeghe P., Mazier D., Vanelle P., Primas N.
RSC Advances 2022, 12(31), 20004-20021.
http://dx.doi.org/10.1039/D2RA01687G
https://hal.archives-ouvertes.fr/hal-03726141

Star-like poly(peptoid)s with selective antibacterial activity
Salas-Ambrosio P., Tronnet A., Badreldin M., Reyes L., Since M., Bourgeade-Delmas S., Dupuy B., Verhaeghe P., Bonduelle C.
Polymer Chemistry 2022, 13(5), 600-612.
http://dx.doi.org/10.1039/D1PY01529J
https://hal.archives-ouvertes.fr/hal-03559890

Versatile activity of a copper(II) complex bearing a N4-tetradentate schiff base ligand with reduced oxygen species
Richezzi M., Ferreyra J., Puzzolo J., Milesi L., Palopoli C. M., Moreno D. M., Hureau C., Signorella S. R.
European Journal of Inorganic Chemistry 2022, (8), e202101042/1-11.
https://doi.org/10.1002/ejic.202101042
https://hal.archives-ouvertes.fr/hal-03549477

Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity
Hureau C.
in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities Govindaraju T. (Ed.). The Royal Society of Chemistry: Cambridge, 2022, pp. 170-192. (978-1-83916-230-5).
https://doi.org/10.1039/9781839162732-00170
https://hal.archives-ouvertes.fr/hal-03528657

Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer’s disease
Atrián-Blasco E., de Cremoux L., Lin X., Mitchell-Heggs R., Sabater L., Blanchard S., Hureau C.
Chemical Communications 2022, 58(14), 2367-2370.
http://dx.doi.org/10.1039/D1CC05792H
https://hal.archives-ouvertes.fr/hal-03547481

2021

The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions
Stefaniak E., Atrian-Blasco E., Goch W., Sabater L., Hureau C., Bal W.
Chemistry – A European Journal 2021, 27(8), 2798-2809.
https://doi.org/10.1002/chem.202004484
https://hal.archives-ouvertes.fr/hal-03203165v1

Copper imbalance in Alzheimer’s disease and its link with the amyloid hypothesis: Towards a combined clinical, chemical, and genetic etiology
Squitti R., Faller P., Hureau C., Granzotto A., White A. R., Kepp K. P.
Journal of Alzheimer’s Disease 2021, 83(1), 23-41.
https://doi.org/10.3233/jad-201556
https://hal.archives-ouvertes.fr/hal-03331612

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides
Salas-Ambrosio P., Tronnet A., Verhaeghe P., Bonduelle C.
Biomacromolecules 2021, 22(1), 57-75.
https://doi.org/10.1021/acs.biomac.0c00797
https://hal.archives-ouvertes.fr/hal-02931945

Cyclic poly(α-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization: Simple access to bioactive backbones
Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas S., Stigliani J.-L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.
Journal of the American Chemical Society 2021, 143(10), 3697-3702.
https://doi.org/10.1021/jacs.0c13231
https://hal.archives-ouvertes.fr/hal-03173586

Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA
Rundstadler T., Mothes E., Amrane S., Stigliani J.-L., Verhaeghe P., Pratviel G.
Journal of Inorganic Biochemistry 2021, 223, 111551/1-10.
https://doi.org/10.1016/j.jinorgbio.2021.111551
https://hal.archives-ouvertes.fr/hal-03312437

Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin
Majdoub S., Garda Z., Oliveira A. C., Relich I., Pallier A., Lacerda S., Hureau C., Geraldes C. F. G. C., Morfin J.-F., Tóth É.
Chemistry – A European Journal 2021, 27, 2009-2020.
https://doi.org/10.1002/chem.202004000
https://hal.archives-ouvertes.fr/hal-03011656

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
Lavigne M., Helynck O., Rigolet P., Boudria-Souilah R., Nowakowski M., Baron B., Brülé S., Hoos S., Raynal B., Guittat L., Beauvineau C., Petres S., Granzhan A., Guillon J., Pratviel G., Teulade-Fichou M.-P., England P., Mergny J.-L., Munier-Lehmann H.
Nucleic Acids Research 2021, 49(13), 7695-7712.
https://doi.org/10.1093/nar/gkab571
https://hal.archives-ouvertes.fr/hal-03281130

Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone
Graur V., Usataia I., Bourosh P., Kravtsov V., Garbuz O., Hureau C., Gulea A.
Applied Organometallic Chemistry 2021, 35(4), e6172/1-17.
https://doi.org/10.1002/aoc.6172
https://hal.archives-ouvertes.fr/hal-03412897

Reproducibility problems of amyloid-β self-assembly and how to deal with them
Faller P., Hureau C.
Frontiers in chemistry 2021, 8611227/1-7.
https://doi.org/10.3389/fchem.2020.611227
https://hal.archives-ouvertes.fr/hal-03203136

Impact of N-truncated Aβ peptides on Cu- and Cu(Aβ)-generated ROS: CuI matters!
Esmieu C., Ferrand G., Borghesani V., Hureau C.
Chemistry – A European Journal 2021, 27(5), 1777-1786.
https://doi.org/10.1002/chem.202003949
https://hal.archives-ouvertes.fr/hal-03383515

Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps
Esmieu C., Balderrama-Martínez-Sotomayor R., Conte-Daban A., Iranzo O., Hureau C.
Inorganic Chemistry 2021, 60(2), 1248-1256.
https://doi.org/10.1021/acs.inorgchem.0c03407
https://hal.archives-ouvertes.fr/hal-03203129

Hybrid bis-histidine phenanthroline-based ligands to lessen Aβ-bound Cu ROS production: An illustration of Cu(I) significance
Drommi M., Rulmont C., Esmieu C., Hureau C.
Molecules 2021, 26(24), 7630/1-15.
https://doi.org/10.3390/molecules26247630
https://hal.archives-ouvertes.fr/hal-03547406

Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface
Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Mergny J.-L., Fojta M.
Electrochimica Acta 2021, 394, 139151/1-11.
https://doi.org/10.1016/j.electacta.2021.139151
https://hal.archives-ouvertes.fr/hal-03357381

A new thienopyrimidinone chemotype shows multistage activity against Plasmodium falciparum, including artemisinin-resistant parasites
Bosson-Vanga H., Primas N., Franetich J.-F., Lavazec C., Gomez L., Ashraf K., Tefit M., Soulard V., Dereuddre-Bosquet N., Le Grand R., Donnette M., Mustière R., Amanzougaghene N., Tajeri S., Suzanne P., Malzert-Fréon A., Rault S., Vanelle P., Hutter S., Cohen A., Snounou G., Roques P., Azas N., Lagardère P., Lisowski V., Masurier N., Nguyen M., Paloque L., Benoit-Vical F., Verhaeghe P., Mazier D., Muralidharan V.
Microbiology Spectrum 2021, 9(2), e00274-21/1-19.
https://doi.org/10.1128/Spectrum.00274-21
https://hal.archives-ouvertes.fr/hal-03363796

Measurement of interpeptidic CuII exchange rate constants of CuII-Amyloid-β complexes to small peptide motifs by tryptophan fluorescence quenching
Beuning C. N., Zocchi L. J., Malikidogo K. P., Esmieu C., Dorlet P., Crans D. C., Hureau C.
Inorganic Chemistry 2021, 60(11), 7650-7659.
https://doi.org/10.1021/acs.inorgchem.0c03555
https://hal.archives-ouvertes.fr/hal-03380483

Solid-state and solution characterizations of [(TMPA)Cu(II)(SO3)] and [(TMPA)Cu(II)(S2O3)] complexes: Application to sulfite and thiosulfate fast detection
Berthonnaud L., Esmieu C., Mallet-Ladeira S., Hureau C.
Journal of Inorganic Biochemistry 2021, 225, 111601/1-9.
https://doi.org/10.1016/j.jinorgbio.2021.111601
https://hal.archives-ouvertes.fr/hal-03394471

A water-soluble peptoid chelator that can remove Cu2+ from amyloid-β peptides and stop the formation of reactive oxygen species associated with Alzheimer’s disease
Behar A. E., Sabater L., Baskin M., Hureau C., Maayan G.
Angewandte Chemie, International Edition 2021, 60(46), 24588-24597.
https://doi.org/10.1002/anie.202109758
https://hal.archives-ouvertes.fr/hal-03395343

Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum
Amrane D., Primas N., Arnold C.-S., Hutter S., Louis B., Sanz-Serrano J., Azqueta A., Amanzougaghene N., Tajeri S., Mazier D., Verhaeghe P., Azas N., Botté C., Vanelle P.
European Journal of Medicinal Chemistry 2021, 224, 113722/1-14.
https://doi.org/10.1016/j.ejmech.2021.113722
https://hal.archives-ouvertes.fr/hal-03323972

2-phenoxy-3-trichloromethylquinoxalines are antiplasmodial aerivatives with activity against the apicoplast of Plasmodium falciparum
Amrane D., Arnold C.-S., Hutter S., Sanz-Serrano J., Collia M., Azqueta A., Paloque L., Cohen A., Amanzougaghene N., Tajeri S., Franetich J.-F., Mazier D., Benoit-Vical F., Verhaeghe P., Azas N., Vanelle P., Botté C., Primas N.
Pharmaceuticals 2021, 14(8), 724/1-24.
https://doi.org/10.3390/ph14080724
https://hal.archives-ouvertes.fr/hal-03323862

Partenariats

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International collaborators

  • S. Signorella, University of Rosario, Argentina
    Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase and plant oxygen release center). Collaboration supported by the PICS program of CNRS for the 2016-2018 period.
  • W. Bal, University of Wroclaw, Poland
    Analytical studies of Cu(II) coordination to peptides and aggregation of truncated peptides.
  • D. Valensin, University of Siena, Italy
    Study of the coordination of Cu(II) ions to the α-synuclein protein involved in Parkinson’s disease.
  • D. Crans, University of Colorado,
    Kinetic studies of metal ion exchange between peptides. Collaboration supported by a Chateaubriand grant for C. Beuning.
  • G. Maayan, Technion University, Israel.
    Peptoid ligands as Cu(II) chelators in Alzheimer’s disease.

French Collaborators

  • K. Reybier, IRD, University of Toulouse
    Study of oxidative stress generated by Cu(Aβ) on cells.
  • P. Genevaux, Laboratory of Microbiology and Molecular Genetics, Toulouse.
    Study of chaperone proteins of amyloid-β peptide aggregation.
  • E. Anxolabéhère-Mallart, University D. Diderot, Paris
    Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase)
  • P. Delangle, Ion Recognition and Coordination Chemistry Laboratory, CEA Grenoble
    Study of Cu(I/II) chelators in the context of Alzheimer’s disease
  • C. Policar, ENS Ulm, Paris
    Study of SOD mimics against oxidative stress in Alzheimer’s disease.
  • N. Delsuc, ENS Ulm, Paris
    Study of Cu(II) peptide complexes with SOD activity
  • R. Tripier and Dr. Maryline Beyler, UMR 6521, Université de Bretagne Occidentale.
    Study of macrocyclic Cu(II) chelators in the context of Alzheimer’s disease.
  • O. Iranzo, Institute of Molecular Sciences of Marseille, UMR 7313, University of Aix – Marseille.
    Study of pseudo-peptide chelators of Cu(II) in the context of Alzheimer’s disease.
  • P. Faller, Institut de Chimie de Strasbourg, UMR7177
    Traceable Cu(II) metallophores as a therapeutic approach in Alzheimer’s disease.
  • S. Blanchard, Institut Parisien de Chimie Moléculaire, UMR 8232
    Study of polyoxometallates in Alzheimer’s disease.
  • S. Hamdi, Human Fertility Research Group, EA 3694 of Paul-Sabatier University
    Study of the role of metal ions in the aggregation of SEMS peptides involved in fertility
  • E. Toth, Molecular Biophysics Center, UPR 4301, Orléans.
    Markers of amylin aggregation involved in type II diabetes.
  • Marc Blanchard, Geosciences Environnement Toulouse, Observatoire Midi-Pyrénées.
    Use of stable isotopes of Cu and Zn ions to study Aβ assembly.
  • O. Maury, F. Riobé, Chemistry Laboratory, ENS Lyon
    Complexes for modulation and monitoring of amyloid aggregation.
  • G. Lippens, LISBP, INSA-Toulouse
    Study of phosphorus chaperones of Tau proteins
  • O. Cuvillier, IPBS, UMR 5089
    Study of cytotoxicity of Cu(Aβ) and restoration of cell survival.
  • E. Benoist, SPCMIB, UMR 5068
    Re(CO)3 complexes for amyloid imaging.
  • N. Giraud, Université de Paris, UMR CNRS 8601
    NMR study of Aβ interaction with external partners.
  • F. Bedos and C. Bacqué, SPCMIB, UMR 5068
    (Clickable) ligands targeting Cu(II) in the Alzheimer’s context.

Financements

Cliquez-ici pour consulter les financeurs

LnZYME,  ANR,
2023-2027
Lanthano-peptides as mimics of lanthanide methanol dehydrogenase enzyme
PI : Emilie Mathieu

Amyl-in-AD, MITI CNRS,
2023-2026
Is amylin the real villain in Alzheimer’s disease ?
PI : Christelle Hureau & Nicolas Vitale

MASAI,  ANR,
2022-2026
Metal-based agents for selective amyloid imaging.
PI : Eva Tòth, Partner : Christelle Hureau
Read more: https://anr.fr/Project-ANR-22-CE44-0002

DREAMY, ANR 2023-2027
Deciphering early steps of self-assembly of amyloid forming peptides
PI : Nicolas Giraud, Partner : Christelle Hureau
Read more: https://anr.fr/Project-ANR-22-CE29-0026

SUPRAMY, ANR PRC 2021-2025
Utilsation de polyanions pour moduler l’auto-assemblage de peptides impliqués dans des maladies amyloïdes
PI : Christelle Hureau
Read more: https://anr.fr/Project-ANR-21-CE06-0030

COPPERATION,  ANR JCJC 2020-2024
Fluorescent ligands: for the rational design of ligands targeting copper ions in Alzheimer’s disease
PI : Charlène Esmieu
Read more: https://anr.fr/Projet-ANR-20-CE07-0009

ANRS, Emerging infectious diseases
2020 – 2023
Function and targeting of G-quadruplexes RNAs from HIV-1
PI : Dr Samir AMRANE (Institut Européen de Chimie Biologie, IECB, Bordeaux),
Partner: Geneviève Pratviel

DIVA, ANR 2016
2016 – 2021
Diabetes Imaging by Visualizing Amylin with Metal-based Probes
PI: Dr. E. Toth (CBM, Orléans), Partner: Christelle Hureau
Read more: https://anr.fr/Project-ANR-16-CE18-0022

CASPER, Fondation France-Alzheimer,

2016-2018
Dynamic Combinatorial Synthesis of Optical Molecular Markers of the Aggregated Amyloid-ß Peptide
PI: B. Mestre-Voegtlé

ALzINK, ERC (European Research Council) StG
2015-2020
Alzheimer’s disease & Zinc : the missing link ?
PI:  Christelle HUREAU
Read more: https://cordis.europa.eu/project/id/638712

AlzPEPS, Fellowship USIAS
2015-2017
Peptides as Cu shuttles
PI: Christelle Hureau & Peter Faller (UMR 7177, Strasbourg)

Recoligo, France-Alzheimer,
2014-2017
Targeting amyloides-ß oligomers
PI: Christelle Hureau

AlzABox, ANR Blanc
2013-2017
Oxidation of the Aβ peptide and consequences in the aetiology of Alzheimer’s Disease
PI: Fabrice Collin  ; Partner: Christelle Hureau
Read more: https://anr.fr/Projet-ANR-13-BSV5-0016

Neurometals, ANR Blanc
2009-2013
Impact of metallic ion in Alzheimer’s disease
PI: Peter Faller
Read more: https://anr.fr/Projet-ANR-09-BLAN-0090

PICS, CNRS-CONICET
2016-2018
Mn-based biosinpired Water-Oxidizing Complex
PI: Christelle Hureau

Alumnae

Cliquez-ici pour voir nos anciens doctorants

  • Antoine TRONNET
    2018-2022   –    Polymeric analog of antimicrobial peptides with anti-Clostridium difficile therapeutic potential
  • Tiffany RUNDSTADLER
    2018-2022   –   G-quadruplex ligands of nucleic acids: modeling, synthesis and antiviral activity
  • Xudong LIN
    2018-2022   –   Synthesis and studies of compounds targeting the aggregation of amyloid-beta peptide
  • Raul BALDERRAMA
    2019   –   Peptidomimetic ligands for the chelation of Cu(II)
  • Ewelina STEFANIAK
    2016-2017  –   Coordination of Cu(II) ions to peptides for SOD activity
  • Amandine VINCENT
    2018-2019   –   Co-aggregation of amyloid peptides
  • Sara AYALA
    2014-2018   –   Role of Zn ions and chaperone proteins in the aggregation of different forms of amyloid-β peptide
  • Alexandre POCINHO
    2014-2018   –   Optimization of molecules for recognition of oligomeric forms of amyloid-β peptides
  • Valentina BORGHESANI
    2015-2018   –   Impact of Zn ions in the aggregation of different forms of amyloid-β peptide
  • Amandine CONTE-DABAN
    2014-2017  –  Role of Cu and Zn ions in the aggregation and toxicity of metal complexes of amyloid-β peptide: mechanistic and therapeutic aspects

 

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