Alzheimer’s and Amyloids, Bioinorganic Chemistry (Team F)
logo équipe F

LCC

Overview

The ALAMBIC team is interested in the roles of metal ions in life. Its main research line focuses on the role of copper and zinc ions in Alzheimer’s disease and in other processes involving amyloid-forming peptides.

Three axes are developed:

(i) A in-depth understanding at the molecular level of the interactions between metal ions and peptides;
(ii) The identification of new chelation-based concepts targeting copper ions bound to peptides, in order to minimize their harmful effects;
(iii) The design of new probes for the detection of amyloids and amyloids formation.

An emerging thematic in the team focuses on the design of artificial lanthanide enzymes.

    Members of the team

    All
    DR1 CNRS – Team leader

    HUREAU Christelle

    Etudiante Licence

    BLANC Camille

    PhD student

    BRISON Adèle

    Master 2

    CAILLAT Antoine

    DE CREMOUX Lucie
    Doctorante

    DE CREMOUX Lucie

    Doctorante

    DROMMI Marielle

    ESMIEU Charlène
    Chargée de Recherche CNRS

    ESMIEU Charlène

    GARNIER Maritie
    ITA

    GARNIER Maritie

    Master 2

    LANTIGNER Lielou

    Doctorante

    LEFEVRE Margot

    Master 2

    MASSOT Mélanie

    Chargée de Recherche CNRS

    MATHIEU Emilie

    Directrice de recherche DR2 CNRS

    PRATVIEL Geneviève

    Doctorant

    RULMONT Clément

    PhD student

    SCHMITT David

    No Results Found

    DR1 CNRS – Team leader

    HUREAU Christelle

    ORCID : 0000-0003-3339-0239
    CV (PDF file)

    C. Hureau finished her PhD in 2003 in Orsay, on Mn-based structural models of the water-oxidizing centre. Then she made three post-docs at the frontier of (bio-)chemistry, advanced spectroscopy and electrochemistry. In 2007, she joined the LCC where she became group leader of “Alzheimer, amyloids and Bio-Inorganic Chemistry” in 2015. Her works focus on role of metal ions in amyloid diseases and on the design of new drugs. See https://hureaulab.wixsite.com/equipeflcc/christelle-hureau-1

    Email:christelle.hureau(at)lcc-toulouse.fr

    Phone:05.61.33.31.62

    Office:B101

    Team:F

    Etudiante Licence

    BLANC Camille

    Email:camille.blanc(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.43

    Bureau:B113

    Equipe:F

    PhD student

    BRISON Adèle

    Email:adele.brison(at)lcc-toulouse.fr

    Phone:05.61.33.31.46

    Office:G171

    Team:F

    Master 2

    CAILLAT Antoine

    Email:antoine.caillat(at)lcc-toulouse.fr

    Téléphone:05.61.33.32.48

    Bureau:B103

    Equipe:F

    Doctorante

    DE CREMOUX Lucie

    Email:lucie.decremoux(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.43

    Bureau:B113

    Equipe:F

    Doctorante

    DROMMI Marielle

    Projet de these : “Design, synthèse et étude de métallopeptidases artificielles dans le contexte de la maladie d’Alzheimer » – sous la supervision des Drs. Christelle Hureau et Charlène Esmieu.

    Vous pouvez trouver mon CV sur https://hureaulab.wixsite.com/equipeflcc/marielle-drommi

    Email:marielle.drommi(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.20

    Bureau:G167

    Equipe:F

    Chargée de Recherche CNRS

    ESMIEU Charlène

    Email: charlene.esmieu(at)lcc-toulouse.fr

    Téléphone:05.61.33.32.48

    Bureau:B103

    Equipe:F

    ITA

    GARNIER Maritie

    Email:maritie.garnier(at)lcc-toulouse.fr

    Phone:05.61.33.32.48

    Office:B103

    Team:F

    Master 2

    LANTIGNER Lielou

    Email:lielou.lantigner(at)lcc-toulouse.fr

    Téléphone:05.61.33.32.48

    Bureau:B103

    Equipe:F

    Doctorante

    LEFEVRE Margot

    Diplômée d’un Master Recherche en chimie des biomolécules de la Faculté des Sciences de Montpellier en 2021, Margot a intégré le Laboratoire de Chimie de Coordination et l’équipe de Christelle Hureau en Janvier 2021 pour son stage de fin d’étude. Actuellement en doctorat dans la même équipe, sous la supervision de Charlène Esmieu, l’objectif de son projet de recherche vise à synthétiser des ligands hybrides, comprenant une séquence peptidique capable de retirer le cuivre(II) de Cu-Aβ et d’arrêter la production d’ERO associée et un synthon organique capable de chelater le zinc et/ou le manganèse afin de pouvoir agir en tant que pro-drogue. Le projet proposé comprend des phases de : (i) synthèse organique et peptidique afin de préparer les nouveaux ligands, (ii) caractérisation physico-chimique (détermination de l’affinité, de la sélectivité, des potentiels redox par UV-vis, fluorescence, RPE, électrochimie) des complexes métalliques (Cu, Zn et Mn) formés à partir de ces ligands, (iii) étude de la capacité des ligands à relarguer le Zn et Mn et à extraire le Cu de Cu-Aβ, (iv) une phase d’étude de l’atténuation de la production d’ERO par ces ligands. Ces études seront réalisées in vitro et in vivo.

    Email:margot.lefevre(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.20

    Bureau:G167

    Equipe:F

    Master 2

    MASSOT Mélanie

    Email:melanie.massot(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.43

    Bureau:B113

    Equipe:F

    Chargée de Recherche CNRS

    MATHIEU Emilie

    Numéro ORCID : 0000-0002-9313-8679

    Emilie Mathieu completed her PhD in 2017 at the Laboratoire des Biomolécules from the Ecole Normale Supérieure in Paris (France), working under the supervision of Clotilde Policar and Nicolas Delsuc. Her work focused on the design of superoxide dismutase mimics (SODm) and on linking the biological activity of SODm with their becoming in cells (speciation, location, accumulation). Then, she joined the group of Eszter Borbas at Uppsala University (Sweden) in which she studied photo-induced electron transfer in luminescent lanthanide (Eu, Yb) complexes, with the aim of providing insights in how to design bright luminescent probes. In 2020, she integrated the ALAMBIC team led by Christelle Hureau as a postdoctoral fellow, before obtaining a permanent position as a Chargée de recherche in the team in 2021. Her current work focus on the design of artificial lanthanide enzymes as mimics of the recently discovered lanthanide methanol dehydrogenases

    Email:emilie.mathieu(at)lcc-toulouse.fr

    Téléphone:05.61.33.32.48

    Bureau:B103

    Equipe:F

    Directrice de recherche DR2 CNRS

    PRATVIEL Geneviève

     

    Email:genevieve.pratviel(at)lcc-toulouse.fr

    Téléphone:05.61.33.31.46

    Bureau:G171

    Equipe:F

    Doctorant

    RULMONT Clément

    Email:clement.rulmont(at)lcc-toulouse.fr

    Téléphone:05.61.33.32.48

    Bureau:B103

    Equipe:F

    PhD student

    SCHMITT David

    Email:david.schmitt(at)lcc-toulouse.fr

    Phone:05.61.33.31.46

    Office:G171

    Team:F

    Research topics

    Team news

    Publications

    2024
    2023

    Effect of metal environment and immobilization on the catalytic activity of a Cu superoxide dismutase mimic
    Richezzi M., Ferreyra J., Signorella S., Palopoli C., Terrestre G., Pellegri N., Hureau C., Signorella S. R.
    Inorganics 2023, 11(11), 425/1-19.
    https://doi.org/10.3390/inorganics11110425
    https://hal.science/hal-04301970

    Synthesis, characterization, and biological properties of the copper(II) complexes with novel ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide
    Rusnac R., Garbuz O., Chumakov Y., Tsapkov V., Hureau C., Istrati D., Gulea A.
    Inorganics 2023, 11(10), 408/1-17.
    https://doi.org/10.3390/inorganics11100408
    https://hal.science/hal-04302011

    Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship
    Lefèvre M., Lantigner L., Andolfo L., Vanucci-Bacqué C., Benoist E., Esmieu C., Bedos-Belval F., Hureau C.
    Comptes Rendus Chimie 2023, 26(S3), 1-11.
    https://doi.org/10.5802/crchim.255
    https://hal.science/hal-04299723

    Novel thienopyrimidones targeting hepatic and erythrocytic stages of Plasmodium parasites with increased microsomal stability
    Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Casanova M., Franetich J.-F., Tajeri S., Malzert-Fréon A., Corvaisier S., Since M., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
    European Journal of Medicinal Chemistry 2023, 261, 115873/1-12.
    https://doi.org/10.1016/j.ejmech.2023.115873
    https://hal.science/hal-04272315

    LPMO-like activity of bioinspired copper complexes: from model substrate to extended polysaccharides
    Leblay R., Delgadillo-Ruiz R., Decroos C., Hureau C., Réglier M., Castillo Pérez I., Faure B., Simaan A. J.
    ChemCatChem 2023, 15(23), e202300933/1-9.
    https://doi.org/10.1002/cctc.202300933
    https://hal.science/hal-04231361

    Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes
    Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Renciuk D., Mergny J.-L., Fojta M.
    Electrochimica Acta 2023, 442, 141878/1-8.
    https://doi.org/10.1016/j.electacta.2023.141878
    https://hal.science/hal-04232807

    Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides
    Falcone E., Hureau C.
    Chemical Society Reviews 2023, 52(19), 6595-6600.
    http://dx.doi.org/10.1039/D3CS00443K
    https://hal.science/hal-04231237

    Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer’s disease?
    Hureau C.
    eBioMedicine 2023, 87, 104403/1-2.
    https://doi.org/10.1016/j.ebiom.2022.104403
    https://hal.science/hal-04231411

    The critical role of ligand flexibility on the activity of free and immobilized Mn superoxide dismutase mimics
    Richezzi M., Signorella S., Palopoli C., Pellegri N., Hureau C., Signorella S. R.
    Inorganics 2023, 11(9), 359/1-22.
    https://doi.org/10.3390/inorganics11090359
    https://hal.science/hal-04231291

    Biomimetic catalysis of nitrite reductase enzyme using copper complexes in chemical and electrochemical reduction of nitrite
    Ferreira M. P., Castro C. B., Honorato J., He S.-Y., Gonçalves Guimarães Júnior W., Esmieu C., Castellano E. E., de Moura A. F., Truzzi D. R., Nascimento O. R., Simonneau A., Marques Netto C. G. C.
    Dalton Transactions 2023, 52(32), 11254-11264.
    http://dx.doi.org/10.1039/D3DT01091K
    https://hal.science/hal-04197074

    Oxidative damages on the Alzheimer’s related-Aβ peptide alters its ability to assemble
    Cheignon C., Collin F., Sabater L., Hureau C.
    Antioxidants 2023, 12(2), 472/1-20.
    https://doi.org/10.3390/antiox12020472
    https://hal.science/hal-03988839

    Ability of azathiacyclen ligands to stop Cu(Aβ)-induced production of reactive oxygen species: [3N1S] is the right donor set
    Malikidogo K. P., Drommi M., Atrián-Blasco E., Hormann J., Kulak N., Esmieu C., Hureau C.
    Chemistry – A European Journal 2023, 29(14), e202203667/1-11.
    https://doi.org/10.1002/chem.202203667
    https://hal.archives-ouvertes.fr/hal-03931017

    New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability
    Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Casanova M., Franetich J.-F., Tajeri S., Malzert-Fréon A., Corvaisier S., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
    European Journal of Medicinal Chemistry 2023, 249, 115115/1-12.
    https://doi.org/10.1016/j.ejmech.2023.115115
    https://hal.science/hal-03942426

    2022

    Improved emission of Yb(iii) ions in triazacyclononane-based macrocyclic ligands compared to cyclen-based ones
    Kiraev S. R., Mathieu E., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
    Dalton Transactions 2022, 51(43), 16596-16604.
    http://dx.doi.org/10.1039/D2DT02266D
    https://hal.science/hal-04297267

    Sensitization pathways in NIR-emitting Yb(III) complexes bearing 0, +1, +2, or +3 charges
    Mathieu E., Kiraev S. R., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
    Journal of the American Chemical Society 2022, 144(46), 21056-21067.
    https://doi.org/10.1021/jacs.2c05813
    https://hal.science/hal-04297298

    Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
    Amrane S., Jaubert C., Bedrat A., Rundstadler T., Recordon-Pinson P., Aknin C., Guédin A., De Rache A., Bartolucci L., Diene I., Lemoine F., Gascuel O., Pratviel G., Mergny J.-L., Andreola M.-L.
    Nucleic Acids Research 2022, 50(21), 12328-12343.
    https://doi.org/10.1093/nar/gkac1030
    https://hal.science/hal-03874577

    Sequence–activity relationship of ATCUN peptides in the context of Alzheimer’s disease
    Lefèvre M., Malikidogo K. P., Esmieu C., Hureau C.
    Molecules 2022, 27(22), 7903/1-17.
    https://doi.org/10.3390/molecules27227903
    https://hal.archives-ouvertes.fr/hal-03875481

    Effect of N-alkylation in N-carboxyanhydride (NCA) ring-opening polymerization kinetics
    Salas-Ambrosio P., Tronnet A., Badreldin M., Ji S., Lecommandoux S., Harrisson S., Verhaeghe P., Bonduelle C.
    Polymer Chemistry 2022, 13, 6149-6161.
    http://dx.doi.org/10.1039/D2PY00985D
    https://hal.archives-ouvertes.fr/hal-03813069

    Synthesis, structure, and biologic activity of some copper, nickel, cobalt, and zinc complexes with 2-formylpyridine N4-allylthiosemicarbazone
    Graur V., Chumakov Y., Garbuz O., Hureau C., Tsapkov V., Gulea A.
    Bioinorganic Chemistry and Applications 2022, 2022, 2705332/1-18.
    https://doi.org/10.1155/2022/2705332
    https://hal.archives-ouvertes.fr/hal-03807954

    Why the Ala-His-His peptide is an appropriate scaffold to remove and redox silence copper ions from the Alzheimer’s-related Aβ peptide
    Gonzalez P., Sabater L., Mathieu E., Faller P., Hureau C.
    Biomolecules 2022, 12(10), 1327/1-14.
    https://doi.org/10.3390/biom12101327
    https://hal.archives-ouvertes.fr/hal-03799992

    Improving aqueous solubility and in vitro pharmacokinetic properties of the 3-nitroimidazo[1,2-a]pyridine antileishmanial pharmacophore
    Paoli-Lombardo R., Primas N., Bourgeade-Delmas S., Hutter S., Sournia-Saquet A., Boudot C., Brenot E., Castera-Ducros C., Corvaisier S., Since M., Malzert-Fréon A., Courtioux B., Valentin A., Verhaeghe P., Azas N., Rathelot P., Vanelle P.
    Pharmaceuticals 2022, 15(8), 998/1-26.
    https://doi.org/10.3390/ph15080998
    https://hal.archives-ouvertes.fr/hal-03755519

    Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis
    Le N.-H., Constant P., Tranier S., Nahoum V., Guillet V., Maveyraud L., Daffé M., Mourey L., Verhaeghe P., Marrakchi H.
    Bioorganic & Medicinal Chemistry 2022, 71116938/1-7.
    https://doi.org/10.1016/j.bmc.2022.116938
    https://hal.archives-ouvertes.fr/hal-03758907

    Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy
    Mustière R., Lagardère P., Hutter S., Dell’Orco V., Amanzougaghene N., Tajeri S., Franetich J.-F., Corvaisier S., Since M., Malzert-Fréon A., Masurier N., Lisowski V., Verhaeghe P., Mazier D., Azas N., Vanelle P., Primas N.
    European Journal of Medicinal Chemistry 2022, 241, 114619/1-13.
    https://doi.org/10.1016/j.ejmech.2022.114619
    https://hal.archives-ouvertes.fr/hal-03737417

    4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives
    Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Franetich J.-F., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
    Pharmaceuticals 2022, 15(7), 820/1-18.
    https://doi.org/10.3390/ph15070820
    https://hal.archives-ouvertes.fr/hal-03725749

    Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation
    Mustière R., Lagardère P., Hutter S., Deraeve C., Schwalen F., Amrane D., Masurier N., Azas N., Lisowski V., Verhaeghe P., Mazier D., Vanelle P., Primas N.
    RSC Advances 2022, 12(31), 20004-20021.
    http://dx.doi.org/10.1039/D2RA01687G
    https://hal.archives-ouvertes.fr/hal-03726141

    Star-like poly(peptoid)s with selective antibacterial activity
    Salas-Ambrosio P., Tronnet A., Badreldin M., Reyes L., Since M., Bourgeade-Delmas S., Dupuy B., Verhaeghe P., Bonduelle C.
    Polymer Chemistry 2022, 13(5), 600-612.
    http://dx.doi.org/10.1039/D1PY01529J
    https://hal.archives-ouvertes.fr/hal-03559890

    Versatile activity of a copper(II) complex bearing a N4-tetradentate schiff base ligand with reduced oxygen species
    Richezzi M., Ferreyra J., Puzzolo J., Milesi L., Palopoli C. M., Moreno D. M., Hureau C., Signorella S. R.
    European Journal of Inorganic Chemistry 2022, (8), e202101042/1-11.
    https://doi.org/10.1002/ejic.202101042
    https://hal.archives-ouvertes.fr/hal-03549477

    Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity
    Hureau C.
    in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities Govindaraju T. (Ed.). The Royal Society of Chemistry: Cambridge, 2022, pp. 170-192. (978-1-83916-230-5).
    https://doi.org/10.1039/9781839162732-00170
    https://hal.archives-ouvertes.fr/hal-03528657

    Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer’s disease
    Atrián-Blasco E., de Cremoux L., Lin X., Mitchell-Heggs R., Sabater L., Blanchard S., Hureau C.
    Chemical Communications 2022, 58(14), 2367-2370.
    http://dx.doi.org/10.1039/D1CC05792H
    https://hal.archives-ouvertes.fr/hal-03547481

    2021
    The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions
    Stefaniak E., Atrian-Blasco E., Goch W., Sabater L., Hureau C., Bal W.
    Chemistry – A European Journal 2021, 27(8), 2798-2809.
    https://doi.org/10.1002/chem.202004484
    https://hal.archives-ouvertes.fr/hal-03203165v1

    Copper imbalance in Alzheimer’s disease and its link with the amyloid hypothesis: Towards a combined clinical, chemical, and genetic etiology
    Squitti R., Faller P., Hureau C., Granzotto A., White A. R., Kepp K. P.
    Journal of Alzheimer’s Disease 2021, 83(1), 23-41.
    https://doi.org/10.3233/jad-201556
    https://hal.archives-ouvertes.fr/hal-03331612

    Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides
    Salas-Ambrosio P., Tronnet A., Verhaeghe P., Bonduelle C.
    Biomacromolecules 2021, 22(1), 57-75.
    https://doi.org/10.1021/acs.biomac.0c00797
    https://hal.archives-ouvertes.fr/hal-02931945

    Cyclic poly(α-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization: Simple access to bioactive backbones
    Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas S., Stigliani J.-L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.
    Journal of the American Chemical Society 2021, 143(10), 3697-3702.
    https://doi.org/10.1021/jacs.0c13231
    https://hal.archives-ouvertes.fr/hal-03173586

    Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA
    Rundstadler T., Mothes E., Amrane S., Stigliani J.-L., Verhaeghe P., Pratviel G.
    Journal of Inorganic Biochemistry 2021, 223, 111551/1-10.
    https://doi.org/10.1016/j.jinorgbio.2021.111551
    https://hal.archives-ouvertes.fr/hal-03312437

    Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin
    Majdoub S., Garda Z., Oliveira A. C., Relich I., Pallier A., Lacerda S., Hureau C., Geraldes C. F. G. C., Morfin J.-F., Tóth É.
    Chemistry – A European Journal 2021, 27, 2009-2020.
    https://doi.org/10.1002/chem.202004000
    https://hal.archives-ouvertes.fr/hal-03011656

    SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
    Lavigne M., Helynck O., Rigolet P., Boudria-Souilah R., Nowakowski M., Baron B., Brülé S., Hoos S., Raynal B., Guittat L., Beauvineau C., Petres S., Granzhan A., Guillon J., Pratviel G., Teulade-Fichou M.-P., England P., Mergny J.-L., Munier-Lehmann H.
    Nucleic Acids Research 2021, 49(13), 7695-7712.
    https://doi.org/10.1093/nar/gkab571
    https://hal.archives-ouvertes.fr/hal-03281130

    Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone
    Graur V., Usataia I., Bourosh P., Kravtsov V., Garbuz O., Hureau C., Gulea A.
    Applied Organometallic Chemistry 2021, 35(4), e6172/1-17.
    https://doi.org/10.1002/aoc.6172
    https://hal.archives-ouvertes.fr/hal-03412897

    Reproducibility problems of amyloid-β self-assembly and how to deal with them
    Faller P., Hureau C.
    Frontiers in chemistry 2021, 8611227/1-7.
    https://doi.org/10.3389/fchem.2020.611227
    https://hal.archives-ouvertes.fr/hal-03203136

    Impact of N-truncated Aβ peptides on Cu- and Cu(Aβ)-generated ROS: CuI matters!
    Esmieu C., Ferrand G., Borghesani V., Hureau C.
    Chemistry – A European Journal 2021, 27(5), 1777-1786.
    https://doi.org/10.1002/chem.202003949
    https://hal.archives-ouvertes.fr/hal-03383515

    Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps
    Esmieu C., Balderrama-Martínez-Sotomayor R., Conte-Daban A., Iranzo O., Hureau C.
    Inorganic Chemistry 2021, 60(2), 1248-1256.
    https://doi.org/10.1021/acs.inorgchem.0c03407
    https://hal.archives-ouvertes.fr/hal-03203129

    Hybrid bis-histidine phenanthroline-based ligands to lessen Aβ-bound Cu ROS production: An illustration of Cu(I) significance
    Drommi M., Rulmont C., Esmieu C., Hureau C.
    Molecules 2021, 26(24), 7630/1-15.
    https://doi.org/10.3390/molecules26247630
    https://hal.archives-ouvertes.fr/hal-03547406

    Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface
    Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Mergny J.-L., Fojta M.
    Electrochimica Acta 2021, 394, 139151/1-11.
    https://doi.org/10.1016/j.electacta.2021.139151
    https://hal.archives-ouvertes.fr/hal-03357381

    A new thienopyrimidinone chemotype shows multistage activity against Plasmodium falciparum, including artemisinin-resistant parasites
    Bosson-Vanga H., Primas N., Franetich J.-F., Lavazec C., Gomez L., Ashraf K., Tefit M., Soulard V., Dereuddre-Bosquet N., Le Grand R., Donnette M., Mustière R., Amanzougaghene N., Tajeri S., Suzanne P., Malzert-Fréon A., Rault S., Vanelle P., Hutter S., Cohen A., Snounou G., Roques P., Azas N., Lagardère P., Lisowski V., Masurier N., Nguyen M., Paloque L., Benoit-Vical F., Verhaeghe P., Mazier D., Muralidharan V.
    Microbiology Spectrum 2021, 9(2), e00274-21/1-19.
    https://doi.org/10.1128/Spectrum.00274-21
    https://hal.archives-ouvertes.fr/hal-03363796

    Measurement of interpeptidic CuII exchange rate constants of CuII-Amyloid-β complexes to small peptide motifs by tryptophan fluorescence quenching
    Beuning C. N., Zocchi L. J., Malikidogo K. P., Esmieu C., Dorlet P., Crans D. C., Hureau C.
    Inorganic Chemistry 2021, 60(11), 7650-7659.
    https://doi.org/10.1021/acs.inorgchem.0c03555
    https://hal.archives-ouvertes.fr/hal-03380483

    Solid-state and solution characterizations of [(TMPA)Cu(II)(SO3)] and [(TMPA)Cu(II)(S2O3)] complexes: Application to sulfite and thiosulfate fast detection
    Berthonnaud L., Esmieu C., Mallet-Ladeira S., Hureau C.
    Journal of Inorganic Biochemistry 2021, 225, 111601/1-9.
    https://doi.org/10.1016/j.jinorgbio.2021.111601
    https://hal.archives-ouvertes.fr/hal-03394471

    A water-soluble peptoid chelator that can remove Cu2+ from amyloid-β peptides and stop the formation of reactive oxygen species associated with Alzheimer’s disease
    Behar A. E., Sabater L., Baskin M., Hureau C., Maayan G.
    Angewandte Chemie, International Edition 2021, 60(46), 24588-24597.
    https://doi.org/10.1002/anie.202109758
    https://hal.archives-ouvertes.fr/hal-03395343

    Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum
    Amrane D., Primas N., Arnold C.-S., Hutter S., Louis B., Sanz-Serrano J., Azqueta A., Amanzougaghene N., Tajeri S., Mazier D., Verhaeghe P., Azas N., Botté C., Vanelle P.
    European Journal of Medicinal Chemistry 2021, 224, 113722/1-14.
    https://doi.org/10.1016/j.ejmech.2021.113722
    https://hal.archives-ouvertes.fr/hal-03323972

    2-phenoxy-3-trichloromethylquinoxalines are antiplasmodial aerivatives with activity against the apicoplast of Plasmodium falciparum
    Amrane D., Arnold C.-S., Hutter S., Sanz-Serrano J., Collia M., Azqueta A., Paloque L., Cohen A., Amanzougaghene N., Tajeri S., Franetich J.-F., Mazier D., Benoit-Vical F., Verhaeghe P., Azas N., Vanelle P., Botté C., Primas N.
    Pharmaceuticals 2021, 14(8), 724/1-24.
    https://doi.org/10.3390/ph14080724
    https://hal.archives-ouvertes.fr/hal-03323862

    Partnerships

    Click here to consult the partners

    International collaborators

    • S. Signorella, University of Rosario, Argentina
      Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase and plant oxygen release center). Collaboration supported by the PICS program of CNRS for the 2016-2018 period.
    • W. Bal, University of Wroclaw, Poland
      Analytical studies of Cu(II) coordination to peptides and aggregation of truncated peptides.
    • D. Valensin, University of Siena, Italy
      Study of the coordination of Cu(II) ions to the α-synuclein protein involved in Parkinson’s disease.
    • D. Crans, University of Colorado,
      Kinetic studies of metal ion exchange between peptides. Collaboration supported by a Chateaubriand grant for C. Beuning.
    • G. Maayan, Technion University, Israel.
      Peptoid ligands as Cu(II) chelators in Alzheimer’s disease.

    French Collaborators

    • K. Reybier, IRD, University of Toulouse
      Study of oxidative stress generated by Cu(Aβ) on cells.
    • P. Genevaux, Laboratory of Microbiology and Molecular Genetics, Toulouse.
      Study of chaperone proteins of amyloid-β peptide aggregation.
    • E. Anxolabéhère-Mallart, University D. Diderot, Paris
      Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase)
    • P. Delangle, Ion Recognition and Coordination Chemistry Laboratory, CEA Grenoble
      Study of Cu(I/II) chelators in the context of Alzheimer’s disease
    • C. Policar, ENS Ulm, Paris
      Study of SOD mimics against oxidative stress in Alzheimer’s disease.
    • N. Delsuc, ENS Ulm, Paris
      Study of Cu(II) peptide complexes with SOD activity
    • R. Tripier and Dr. Maryline Beyler, UMR 6521, Université de Bretagne Occidentale.
      Study of macrocyclic Cu(II) chelators in the context of Alzheimer’s disease.
    • O. Iranzo, Institute of Molecular Sciences of Marseille, UMR 7313, University of Aix – Marseille.
      Study of pseudo-peptide chelators of Cu(II) in the context of Alzheimer’s disease.
    • P. Faller, Institut de Chimie de Strasbourg, UMR7177
      Traceable Cu(II) metallophores as a therapeutic approach in Alzheimer’s disease.
    • S. Blanchard, Institut Parisien de Chimie Moléculaire, UMR 8232
      Study of polyoxometallates in Alzheimer’s disease.
    • S. Hamdi, Human Fertility Research Group, EA 3694 of Paul-Sabatier University
      Study of the role of metal ions in the aggregation of SEMS peptides involved in fertility
    • E. Toth, Molecular Biophysics Center, UPR 4301, Orléans.
      Markers of amylin aggregation involved in type II diabetes.
    • Marc Blanchard, Geosciences Environnement Toulouse, Observatoire Midi-Pyrénées.
      Use of stable isotopes of Cu and Zn ions to study Aβ assembly.
    • O. Maury, F. Riobé, Chemistry Laboratory, ENS Lyon
      Complexes for modulation and monitoring of amyloid aggregation.
    • G. Lippens, LISBP, INSA-Toulouse
      Study of phosphorus chaperones of Tau proteins
    • O. Cuvillier, IPBS, UMR 5089
      Study of cytotoxicity of Cu(Aβ) and restoration of cell survival.
    • E. Benoist, SPCMIB, UMR 5068
      Re(CO)3 complexes for amyloid imaging.
    • N. Giraud, Université de Paris, UMR CNRS 8601
      NMR study of Aβ interaction with external partners.
    • F. Bedos and C. Bacqué, SPCMIB, UMR 5068
      (Clickable) ligands targeting Cu(II) in the Alzheimer’s context.

    Funding

    Click here to consult the funders

    LnZYME,  ANR,
    2023-2027
    Lanthano-peptides as mimics of lanthanide methanol dehydrogenase enzyme
    PI : Emilie Mathieu

    Amyl-in-AD, MITI CNRS,
    2023-2026
    Is amylin the real villain in Alzheimer’s disease ?
    PI : Christelle Hureau & Nicolas Vitale

    MASAI,  ANR,
    2022-2026
    Metal-based agents for selective amyloid imaging.
    PI : Eva Tòth, Partner : Christelle Hureau
    Read more: https://anr.fr/Project-ANR-22-CE44-0002

    DREAMY, ANR 2023-2027
    Deciphering early steps of self-assembly of amyloid forming peptides
    PI : Nicolas Giraud, Partner : Christelle Hureau
    Read more: https://anr.fr/Project-ANR-22-CE29-0026

    SUPRAMY, ANR PRC 2021-2025
    Polyanions to tune the supramolecular assembly of amyloid-forming peptides (SUPRAMY)
    PI : Christelle Hureau
    Read more: https://anr.fr/Project-ANR-21-CE06-0030

    COPPERATION,  ANR JCJC 2020-2024
    Fluorescent ligands: for the rational design of ligands targeting copper ions in Alzheimer’s disease
    PI : Charlène Esmieu
    Read more: https://anr.fr/Projet-ANR-20-CE07-0009

    ANRS, Emerging infectious diseases
    2020 – 2023
    Function and targeting of G-quadruplexes RNAs from HIV-1
    PI : Dr Samir AMRANE (Institut Européen de Chimie Biologie, IECB, Bordeaux),
    Partner: Geneviève Pratviel

    DIVA, ANR 2016
    2016 – 2021
    Diabetes Imaging by Visualizing Amylin with Metal-based Probes
    PI: Dr. E. Toth (CBM, Orléans), Partner: Christelle Hureau
    Read more: https://anr.fr/Project-ANR-16-CE18-0022

    CASPER, Fondation France-Alzheimer,
    2016-2018
    Dynamic Combinatorial Synthesis of Optical Molecular Markers of the Aggregated Amyloid-ß Peptide
    PI: B. Mestre-Voegtlé

    ALzINK, ERC (European Research Council) StG
    2015-2020
    Alzheimer’s disease & Zinc : the missing link ?
    PI:  Christelle HUREAU
    Read more: https://cordis.europa.eu/project/id/638712

    AlzPEPS, Fellowship USIAS
    2015-2017
    Peptides as Cu shuttles
    PI: Christelle Hureau & Peter Faller (UMR 7177, Strasbourg)

    Recoligo, France-Alzheimer,
    2014-2017
    Targeting amyloides-ß oligomers
    PI: Christelle Hureau

    AlzABox, ANR Blanc
    2013-2017
    Oxidation of the Aβ peptide and consequences in the aetiology of Alzheimer’s Disease
    PI: Fabrice Collin  ; Partner: Christelle Hureau
    Read more: https://anr.fr/Projet-ANR-13-BSV5-0016

    Neurometals, ANR Blanc
    2009-2013
    Impact of metallic ion in Alzheimer’s disease
    PI: Peter Faller
    Read more: https://anr.fr/Projet-ANR-09-BLAN-0090

    PICS, CNRS-CONICET
    2016-2018
    Mn-based biosinpired Water-Oxidizing Complex
    PI: Christelle Hureau

    Alumnae

    Click here to view

     

    • Antoine TRONNET
      2018-2022   –    Polymeric analog of antimicrobial peptides with anti-Clostridium difficile therapeutic potential
    • Tiffany RUNDSTADLER
      2018-2022   –   G-quadruplex ligands of nucleic acids: modeling, synthesis and antiviral activity
    • Xudong LIN
      2018-2022   –   Synthesis and studies of compounds targeting the aggregation of amyloid-beta peptide
    • Raul BALDERRAMA
      2019   –   Peptidomimetic ligands for the chelation of Cu(II)
    • Ewelina STEFANIAK
      2016-2017  –   Coordination of Cu(II) ions to peptides for SOD activity
    • Amandine VINCENT
      2018-2019   –   Co-aggregation of amyloid peptides
    • Sara AYALA
      2014-2018   –   Role of Zn ions and chaperone proteins in the aggregation of different forms of amyloid-β peptide
    • Alexandre POCINHO
      2014-2018   –   Optimization of molecules for recognition of oligomeric forms of amyloid-β peptides
    • Valentina BORGHESANI
      2015-2018   –   Impact of Zn ions in the aggregation of different forms of amyloid-β peptide
    • Amandine CONTE-DABAN
      2014-2017  –  Role of Cu and Zn ions in the aggregation and toxicity of metal complexes of amyloid-β peptide: mechanistic and therapeutic aspects

     

    LCC

    Laboratoire de chimie de coordination du CNRS

    205 route de Narbonne, BP 44099
    31077 Toulouse cedex 4
    France

    + 33 5 61 33 31 00