Alzheimer’s and Amyloids, Bioinorganic Chemistry (Team F)
logo équipe F



The ALAMBIC team is interested in the roles of metal ions in life. Its main research line focuses on the role of copper and zinc ions in Alzheimer’s disease and in other processes involving amyloid-forming peptides.

Three axes are developed:

(i) A in-depth understanding at the molecular level of the interactions between metal ions and peptides;
(ii) The identification of new chelation-based concepts targeting copper ions bound to peptides, in order to minimize their harmful effects;
(iii) The design of new probes for the detection of amyloids and amyloids formation. A new theme investigates the role of lanthanides in living organisms in link with the recent discovery of bacteria using these elements.

Members of the team


Research topics

Team news

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Ability of azathiacyclen ligands to stop Cu(Aβ)-induced production of reactive oxygen species: [3N1S] is the right donor set
Malikidogo K. P., Drommi M., Atrián-Blasco E., Hormann J., Kulak N., Esmieu C., Hureau C.
Chemistry – A European Journal 2023,

New antiplasmodial 4-amino-thieno[3,2-d]pyrimidines with improved intestinal permeability and microsomal stability
Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Casanova M., Franetich J.-F., Tajeri S., Malzert-Fréon A., Corvaisier S., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
European Journal of Medicinal Chemistry 2023, 249, 115115/1-12.

Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Amrane S., Jaubert C., Bedrat A., Rundstadler T., Recordon-Pinson P., Aknin C., Guédin A., De Rache A., Bartolucci L., Diene I., Lemoine F., Gascuel O., Pratviel G., Mergny J.-L., Andreola M.-L.
Nucleic Acids Research 2022, 50(21), 12328-12343.

Sequence–activity relationship of ATCUN peptides in the context of Alzheimer’s disease
Lefèvre M., Malikidogo K. P., Esmieu C., Hureau C.
Molecules 2022, 27(22), 7903/1-17.

Effect of N-alkylation in N-carboxyanhydride (NCA) ring-opening polymerization kinetics
Salas-Ambrosio P., Tronnet A., Badreldin M., Ji S., Lecommandoux S., Harrisson S., Verhaeghe P., Bonduelle C.
Polymer Chemistry 2022, 13, 6149-6161.

Synthesis, structure, and biologic activity of some copper, nickel, cobalt, and zinc complexes with 2-formylpyridine N4-allylthiosemicarbazone
Graur V., Chumakov Y., Garbuz O., Hureau C., Tsapkov V., Gulea A.
Bioinorganic Chemistry and Applications 2022, 2022, 2705332/1-18.

Why the Ala-His-His peptide is an appropriate scaffold to remove and redox silence copper ions from the Alzheimer’s-related Aβ peptide
Gonzalez P., Sabater L., Mathieu E., Faller P., Hureau C.
Biomolecules 2022, 12(10), 1327/1-14.

Improving aqueous solubility and in vitro pharmacokinetic properties of the 3-nitroimidazo[1,2-a]pyridine antileishmanial pharmacophore
Paoli-Lombardo R., Primas N., Bourgeade-Delmas S., Hutter S., Sournia-Saquet A., Boudot C., Brenot E., Castera-Ducros C., Corvaisier S., Since M., Malzert-Fréon A., Courtioux B., Valentin A., Verhaeghe P., Azas N., Rathelot P., Vanelle P.
Pharmaceuticals 2022, 15(8), 998/1-26.

Drug screening approach against mycobacterial fatty acyl-AMP ligase FAAL32 renews the interest of the salicylanilide pharmacophore in the fight against tuberculosis
Le N.-H., Constant P., Tranier S., Nahoum V., Guillet V., Maveyraud L., Daffé M., Mourey L., Verhaeghe P., Marrakchi H.
Bioorganic & Medicinal Chemistry 2022, 71116938/1-7.

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy
Mustière R., Lagardère P., Hutter S., Dell’Orco V., Amanzougaghene N., Tajeri S., Franetich J.-F., Corvaisier S., Since M., Malzert-Fréon A., Masurier N., Lisowski V., Verhaeghe P., Mazier D., Azas N., Vanelle P., Primas N.
European Journal of Medicinal Chemistry 2022, 241, 114619/1-13.

4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives
Lagardère P., Mustière R., Amanzougaghene N., Hutter S., Franetich J.-F., Azas N., Vanelle P., Verhaeghe P., Primas N., Mazier D., Masurier N., Lisowski V.
Pharmaceuticals 2022, 15(7), 820/1-18.

Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation
Mustière R., Lagardère P., Hutter S., Deraeve C., Schwalen F., Amrane D., Masurier N., Azas N., Lisowski V., Verhaeghe P., Mazier D., Vanelle P., Primas N.
RSC Advances 2022, 12(31), 20004-20021.

Star-like poly(peptoid)s with selective antibacterial activity
Salas-Ambrosio P., Tronnet A., Badreldin M., Reyes L., Since M., Bourgeade-Delmas S., Dupuy B., Verhaeghe P., Bonduelle C.
Polymer Chemistry 2022, 13(5), 600-612.

Versatile activity of a copper(II) complex bearing a N4-tetradentate schiff base ligand with reduced oxygen species
Richezzi M., Ferreyra J., Puzzolo J., Milesi L., Palopoli C. M., Moreno D. M., Hureau C., Signorella S. R.
European Journal of Inorganic Chemistry 2022, (8), e202101042/1-11.

Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity
Hureau C.
in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities Govindaraju T. (Ed.). The Royal Society of Chemistry: Cambridge, 2022, pp. 170-192. (978-1-83916-230-5).

Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer’s disease
Atrián-Blasco E., de Cremoux L., Lin X., Mitchell-Heggs R., Sabater L., Blanchard S., Hureau C.
Chemical Communications 2022, 58(14), 2367-2370.

The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions
Stefaniak E., Atrian-Blasco E., Goch W., Sabater L., Hureau C., Bal W.
Chemistry – A European Journal 2021, 27(8), 2798-2809.

Copper imbalance in Alzheimer’s disease and its link with the amyloid hypothesis: Towards a combined clinical, chemical, and genetic etiology
Squitti R., Faller P., Hureau C., Granzotto A., White A. R., Kepp K. P.
Journal of Alzheimer’s Disease 2021, 83(1), 23-41.

Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides
Salas-Ambrosio P., Tronnet A., Verhaeghe P., Bonduelle C.
Biomacromolecules 2021, 22(1), 57-75.

Cyclic poly(α-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization: Simple access to bioactive backbones
Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas S., Stigliani J.-L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.
Journal of the American Chemical Society 2021, 143(10), 3697-3702.

Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA
Rundstadler T., Mothes E., Amrane S., Stigliani J.-L., Verhaeghe P., Pratviel G.
Journal of Inorganic Biochemistry 2021, 223, 111551/1-10.

Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin
Majdoub S., Garda Z., Oliveira A. C., Relich I., Pallier A., Lacerda S., Hureau C., Geraldes C. F. G. C., Morfin J.-F., Tóth É.
Chemistry – A European Journal 2021, 27, 2009-2020.

SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
Lavigne M., Helynck O., Rigolet P., Boudria-Souilah R., Nowakowski M., Baron B., Brülé S., Hoos S., Raynal B., Guittat L., Beauvineau C., Petres S., Granzhan A., Guillon J., Pratviel G., Teulade-Fichou M.-P., England P., Mergny J.-L., Munier-Lehmann H.
Nucleic Acids Research 2021, 49(13), 7695-7712.

Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone
Graur V., Usataia I., Bourosh P., Kravtsov V., Garbuz O., Hureau C., Gulea A.
Applied Organometallic Chemistry 2021, 35(4), e6172/1-17.

Reproducibility problems of amyloid-β self-assembly and how to deal with them
Faller P., Hureau C.
Frontiers in chemistry 2021, 8611227/1-7.

Impact of N-truncated Aβ peptides on Cu- and Cu(Aβ)-generated ROS: CuI matters!
Esmieu C., Ferrand G., Borghesani V., Hureau C.
Chemistry – A European Journal 2021, 27(5), 1777-1786.

Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps
Esmieu C., Balderrama-Martínez-Sotomayor R., Conte-Daban A., Iranzo O., Hureau C.
Inorganic Chemistry 2021, 60(2), 1248-1256.

Hybrid bis-histidine phenanthroline-based ligands to lessen Aβ-bound Cu ROS production: An illustration of Cu(I) significance
Drommi M., Rulmont C., Esmieu C., Hureau C.
Molecules 2021, 26(24), 7630/1-15.

Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface
Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Mergny J.-L., Fojta M.
Electrochimica Acta 2021, 394, 139151/1-11.

A new thienopyrimidinone chemotype shows multistage activity against Plasmodium falciparum, including artemisinin-resistant parasites
Bosson-Vanga H., Primas N., Franetich J.-F., Lavazec C., Gomez L., Ashraf K., Tefit M., Soulard V., Dereuddre-Bosquet N., Le Grand R., Donnette M., Mustière R., Amanzougaghene N., Tajeri S., Suzanne P., Malzert-Fréon A., Rault S., Vanelle P., Hutter S., Cohen A., Snounou G., Roques P., Azas N., Lagardère P., Lisowski V., Masurier N., Nguyen M., Paloque L., Benoit-Vical F., Verhaeghe P., Mazier D., Muralidharan V.
Microbiology Spectrum 2021, 9(2), e00274-21/1-19.

Measurement of interpeptidic CuII exchange rate constants of CuII-Amyloid-β complexes to small peptide motifs by tryptophan fluorescence quenching
Beuning C. N., Zocchi L. J., Malikidogo K. P., Esmieu C., Dorlet P., Crans D. C., Hureau C.
Inorganic Chemistry 2021, 60(11), 7650-7659.

Solid-state and solution characterizations of [(TMPA)Cu(II)(SO3)] and [(TMPA)Cu(II)(S2O3)] complexes: Application to sulfite and thiosulfate fast detection
Berthonnaud L., Esmieu C., Mallet-Ladeira S., Hureau C.
Journal of Inorganic Biochemistry 2021, 225, 111601/1-9.

A water-soluble peptoid chelator that can remove Cu2+ from amyloid-β peptides and stop the formation of reactive oxygen species associated with Alzheimer’s disease
Behar A. E., Sabater L., Baskin M., Hureau C., Maayan G.
Angewandte Chemie, International Edition 2021, 60(46), 24588-24597.

Antiplasmodial 2-thiophenoxy-3-trichloromethyl quinoxalines target the apicoplast of Plasmodium falciparum
Amrane D., Primas N., Arnold C.-S., Hutter S., Louis B., Sanz-Serrano J., Azqueta A., Amanzougaghene N., Tajeri S., Mazier D., Verhaeghe P., Azas N., Botté C., Vanelle P.
European Journal of Medicinal Chemistry 2021, 224, 113722/1-14.

2-phenoxy-3-trichloromethylquinoxalines are antiplasmodial aerivatives with activity against the apicoplast of Plasmodium falciparum
Amrane D., Arnold C.-S., Hutter S., Sanz-Serrano J., Collia M., Azqueta A., Paloque L., Cohen A., Amanzougaghene N., Tajeri S., Franetich J.-F., Mazier D., Benoit-Vical F., Verhaeghe P., Azas N., Vanelle P., Botté C., Primas N.
Pharmaceuticals 2021, 14(8), 724/1-24.


Click here to consult the partners

International collaborators

  • S. Signorella, University of Rosario, Argentina
    Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase and plant oxygen release center). Collaboration supported by the PICS program of CNRS for the 2016-2018 period.
  • W. Bal, University of Wroclaw, Poland
    Analytical studies of Cu(II) coordination to peptides and aggregation of truncated peptides.
  • D. Valensin, University of Siena, Italy
    Study of the coordination of Cu(II) ions to the α-synuclein protein involved in Parkinson’s disease.
  • D. Crans, University of Colorado,
    Kinetic studies of metal ion exchange between peptides. Collaboration supported by a Chateaubriand grant for C. Beuning.
  • G. Maayan, Technion University, Israel.
    Peptoid ligands as Cu(II) chelators in Alzheimer’s disease.

French Collaborators

  • K. Reybier, IRD, University of Toulouse
    Study of oxidative stress generated by Cu(Aβ) on cells.
  • P. Genevaux, Laboratory of Microbiology and Molecular Genetics, Toulouse.
    Study of chaperone proteins of amyloid-β peptide aggregation.
  • E. Anxolabéhère-Mallart, University D. Diderot, Paris
    Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase)
  • P. Delangle, Ion Recognition and Coordination Chemistry Laboratory, CEA Grenoble
    Study of Cu(I/II) chelators in the context of Alzheimer’s disease
  • C. Policar, ENS Ulm, Paris
    Study of SOD mimics against oxidative stress in Alzheimer’s disease.
  • N. Delsuc, ENS Ulm, Paris
    Study of Cu(II) peptide complexes with SOD activity
  • R. Tripier and Dr. Maryline Beyler, UMR 6521, Université de Bretagne Occidentale.
    Study of macrocyclic Cu(II) chelators in the context of Alzheimer’s disease.
  • O. Iranzo, Institute of Molecular Sciences of Marseille, UMR 7313, University of Aix – Marseille.
    Study of pseudo-peptide chelators of Cu(II) in the context of Alzheimer’s disease.
  • P. Faller, Institut de Chimie de Strasbourg, UMR7177
    Traceable Cu(II) metallophores as a therapeutic approach in Alzheimer’s disease.
  • S. Blanchard, Institut Parisien de Chimie Moléculaire, UMR 8232
    Study of polyoxometallates in Alzheimer’s disease.
  • S. Hamdi, Human Fertility Research Group, EA 3694 of Paul-Sabatier University
    Study of the role of metal ions in the aggregation of SEMS peptides involved in fertility
  • E. Toth, Molecular Biophysics Center, UPR 4301, Orléans.
    Markers of amylin aggregation involved in type II diabetes.
  • Marc Blanchard, Geosciences Environnement Toulouse, Observatoire Midi-Pyrénées.
    Use of stable isotopes of Cu and Zn ions to study Aβ assembly.
  • O. Maury, F. Riobé, Chemistry Laboratory, ENS Lyon
    Complexes for modulation and monitoring of amyloid aggregation.
  • G. Lippens, LISBP, INSA-Toulouse
    Study of phosphorus chaperones of Tau proteins
  • O. Cuvillier, IPBS, UMR 5089
    Study of cytotoxicity of Cu(Aβ) and restoration of cell survival.
  • E. Benoist, SPCMIB, UMR 5068
    Re(CO)3 complexes for amyloid imaging.
  • N. Giraud, Université de Paris, UMR CNRS 8601
    NMR study of Aβ interaction with external partners.
  • F. Bedos and C. Bacqué, SPCMIB, UMR 5068
    (Clickable) ligands targeting Cu(II) in the Alzheimer’s context.


Click here to consult the funders

Polyanions to tune the supramolecular assembly of amyloid-forming peptides (SUPRAMY)
PI : Christelle Hureau

Fluorescent ligands: for the rational design of ligands targeting copper ions in Alzheimer’s disease
PI : Charlène Esmieu
Read more:

ANRS, Emerging infectious diseases
2020 – 2023
Function and targeting of G-quadruplexes RNAs from HIV-1
PI : Dr Samir AMRANE (Institut Européen de Chimie Biologie, IECB, Bordeaux), Partner: Geneviève Pratviel

DIVA, ANR 2016
2016 – 2021
Diabetes Imaging by Visualizing Amylin with Metal-based Probes
PI: Dr. E. Toth (CBM, Orléans), Partner: Christelle Hureau
Read more:

CASPER, Fondation France-Alzheimer,

Dynamic Combinatorial Synthesis of Optical Molecular Markers of the Aggregated Amyloid-ß Peptide
PI: B. Mestre-Voegtlé

ALzINK, ERC (European Research Council) StG
Alzheimer’s disease & Zinc : the missing link ?
PI:  Christelle HUREAU
Read more:

AlzPEPS, Fellowship USIAS
Peptides as Cu shuttles
PI: Christelle Hureau & Peter Faller (UMR 7177, Strasbourg)

Recoligo, France-Alzheimer,
Targeting amyloides-ß oligomers
PI: Christelle Hureau

AlzABox, ANR Blanc
Oxidation of the Aβ peptide and consequences in the aetiology of Alzheimer’s Disease
PI: Fabrice Collin  ; Partner: Christelle Hureau
Read more:

Neurometals, ANR Blanc
Impact of metallic ion in Alzheimer’s disease
PI: Peter Faller
Read more:

Mn-based biosinpired Water-Oxidizing Complex
PI: Christelle Hureau




Click here to view


  • Antoine TRONNET
    2018-2022   –    Polymeric analog of antimicrobial peptides with anti-Clostridium difficile therapeutic potential
    2018-2022   –   G-quadruplex ligands of nucleic acids: modeling, synthesis and antiviral activity
  • Xudong LIN
    2018-2022   –   Synthesis and studies of compounds targeting the aggregation of amyloid-beta peptide
    2019   –   Peptidomimetic ligands for the chelation of Cu(II)
  • Ewelina STEFANIAK
    2016-2017  –   Coordination of Cu(II) ions to peptides for SOD activity
  • Amandine VINCENT
    2018-2019   –   Co-aggregation of amyloid peptides
  • Sara AYALA
    2014-2018   –   Role of Zn ions and chaperone proteins in the aggregation of different forms of amyloid-β peptide
  • Alexandre POCINHO
    2014-2018   –   Optimization of molecules for recognition of oligomeric forms of amyloid-β peptides
  • Valentina BORGHESANI
    2015-2018   –   Impact of Zn ions in the aggregation of different forms of amyloid-β peptide
  • Amandine CONTE-DABAN
    2014-2017  –  Role of Cu and Zn ions in the aggregation and toxicity of metal complexes of amyloid-β peptide: mechanistic and therapeutic aspects



Laboratoire de chimie de coordination du CNRS

205 route de Narbonne, BP 44099
31077 Toulouse cedex 4

+ 33 5 61 33 31 00