LCC
Activités de l’équipe
L’équipe ALAMBIC s’intéresse aux rôles des ions métalliques dans le vivant. La thématique principale concerne le rôle des ions cuivre et zinc dans la maladie d’Alzheimer et dans d’autres processus faisant intervenir des peptides formant des amyloïdes. Une nouvelle thématique dans l’équipe concerne la conception de peptides et protéines liant les lanthanides.
Les recherches de l’équipe s’articulent autour de quatre thèmes :
- Mécanismes pathologiques associés aux métaux dans la maladie d’Alzheimer ;
- Approches thérapeutiques contre la maladie d’Alzheimer ;
- Outils pour suivre et imager l’autoassemblage de peptides amyloïdes ;
- Catalyse bio-inspirée
(Pour le contenu de chaque thème, voir ci-dessous)
Membres de l’équipe
HUREAU Christelle
BAUDIN Antoine
BRISON Adèle
CARRASCO Romain
ESMIEU Charlène
FALCONE Enrico
GARNIER Maritie
MATHIEU Emilie
ROSSOTTI Mélanie
SABATER Laurent
SCHMITT David
SILVADEMENEZES Matheus
VOGE Alicia
Aucun résultat trouvé
Thèmes de recherche
1. Mécanismes pathologiques associés aux métaux dans la maladie d’Alzheimer
(C. Hureau)
2. Approches thérapeutiques contre la maladie d’Alzheimer
Axe 1. La chélation sélective du Cu(II) et du Cu(I) (C. Esmieu)
Axe 2. Echafaudages inorganiques comme modulateurs de l’auto-assemblage des peptides amyloïdogéniques (C. Hureau)
3. Outils pour suivre et imager l’auto-assemblage de peptides amyloïdogéniques
Axe 1. Complexes à base de Ln pour détecter les amyloïdes et leur formation (C. Hureau)
Axe 2. Outils d’imagerie basés sur la lanmoduline (E. Falcone)
4. Catalyse bioinspirée
Axe 1. Enzymes artificielles à base de lanthanides (E. Mathieu)
Axe 2. Modèles peptidiques des LPMO (C. Hureau)
Actualités de l’équipe
Peptides et protéines fixant les lanthanides(III) : propriétés de coordination et applications – En couverture de ChemSocRev
Enrico Falcone, Emilie Mathieu, Christelle Hureau
Journée de séminaires de l’équipe F « Alambic » 7 Novembre 2025
3 conférences plénières à 09h, 11h et 14h.
Distinction : Charlène Esmieu et Nuria Romero lauréates du Young Investigator Award de l’ICT
La médaille Young Investigator Award de l’ICT a été remise aux deux lauréates au cours de la journée de convivialité du jeudi 10 juillet 2025.
Publications
2025
Targeting of β-amyloid peptide fibers, a biomarker of Alzheimer’s disease, by designing specifically functionalized iron oxide nanoparticles
Guerrero Porras G. R., Brison A., Becker A., Le Calvé S., David M., Ulrich G., Mazan V., Schmutz M., Bigo-Simon A., Mertz D., Kiefer C., Bencomo Martínez A., Rodríguez Tanty C., Díaz García A. M., Hureau C., Sablón Carrazana M., Bégin-Colin S.
ACS Appl. Nano Mater. 2025, 8(43), 20822-20834.
10.1021/acsanm.5c03459 – hal-05354610
Constant pH molecular dynamics simulation of pH effects on amyloid-β structure, dynamics, and metal-binding
Albrahadi T., Hureau C., Platts J. A.
Chem. – Eur. J. 2025, 31(34), e202500547/1-11.
10.1002/chem.202500547 – hal-05352635
A cocktail of two chelators is not better than one ligand in excess to halt Cu,Zn-(Amyloid-β)-induced ROS production in the context of Alzheimer’s disease
Bagrel M., Hureau C., Falcone E.
Inorg. Chem. 2025, 64(42), 20875-20880.
10.1021/acs.inorgchem.5c03352 – hal-05332720
Lanthanide(III)-binding peptides and proteins: coordination properties and applications
Falcone E., Mathieu E., Hureau C.
Chem. Soc. Rev. 2025, 54(20), 9245-9288.
10.1039/D4CS01148A – hal-05273561
Modulation of Aβ1–40 and Aβ4–40 co-assembly by zinc: getting closer to the biological reality
de Cremoux L., Falcone E., Schmitt D., Stefaniak E., Wiśniewska M. D., Vitale N., Bal W., Hureau C.
Inorg. Chem. Front. 2025, 12(23), 7827-7844.
10.1039/D5QI00850F – hal-05065818
A 19F-ATCUN peptide NMR probe for selective Cu2+ or Ni2+ sensing in complex biological media
Tilly M.-J., Falcone E., Kieffer B., François Y.-N., Faller P., Desage-El Murr M., Raibaut L.
Chem. – Eur. J. 2025, 31(53), e01784/1-5.
10.1002/chem.202501784 – hal-05229384
The different cellular entry routes for drug delivery using cell penetrating peptides
Okafor M., Schmitt D., Ory S., Gasman S., Hureau C., Faller P., Vitale N.
Biol. Cell 2025, 117(6), e70012/1-15.
10.1111/boc.70012 – hal-05221252
Cu(I) chelators: Useful tools to reveal and control Cu(I) homeostasis and toxicity
Esmieu C., Hostachy S., Hureau C.
Coord. Chem. Rev. 2025, 539, 216684/1-20.
10.1016/j.ccr.2025.216684 – hal-05085144
Lanthanide(III)-dependent hydration of the methanol dehydrogenase cofactor, pyrroloquinoline quinone
Blanc C., Oriol L., Rajeshkumar T., Bijani C., Serpentini C.-L., Giraud N., Maron L., Hureau C., Mathieu E.
J. Inorg. Biochem. 2025, 270, 112924/1-8.
10.1016/j.jinorgbio.2025.112924 – hal-05085198
Modulation of Aβ1-40 and Aβ4-40 co-assembly by Zinc: getting closer to the biological reality
de Cremoux L., Falcone E., Schmitt D., Stefaniak E., Wiśniewska M. D., Vitale N, Bal W., Hureau C.
ChemRxiv 2025
10.26434/chemrxiv-2025-65v0m – hal-05065818
When metal complexes evolve, and a minor species is the most active: The case of bis(phenanthroline)copper in the catalysis of glutathione oxidation and hydroxyl radical generation
Falcone E., Vigna V., Schueffl H., Stellato F., Vileno B., Bouraguba M., Mazzone G., Proux O., Morante S., Heffeter P., Sicilia E., Faller P.
Angew. Chem., Int. Ed. 2025, 64(2), e202414652/1-10.
10.1002/anie.202414652 – hal-04774796
2024
Mécanismes moléculaires autour des métaux : du vivant aux applications
Hureau C., Léger C., Gattas W., Michaud-Soret I., Bertrand H. C., Lebrun V., Desage-El Murr M., Bertrand B.
L’Actualité Chimique 2024, 499, 13-14.
https://hal.science/hal-04975335
Une nouvelle famille de ligands en vue d’une thérapie par chélation contre la maladie d’Alzheimer
Esmieu C., Hureau C.
L’Actualité Chimique 2024, 499, 17-18.
https://hal.science/hal-04975265
Des polyoxométallates pour cibler la maladie d’Alzheimer
Blanchard S., Hureau C.
L’Actualité Chimique 2024, 499, 18.
https://hal.science/hal-04975272
Les méthodes pour la chimie bioinorganique
Hureau C.
L’Actualité Chimique 2024, 499, 54-55.
https://hal.science/hal-04975345
Sonder le vivant grâce à des complexes de lanthanides plus luminescents
Mathieu E., Borbas K. E.
L’Actualité Chimique 2024, 499, 57-58.
https://hal.science/hal-0497527
Bioinorganic chemistry of copper: from biochemistry to pharmacology
Da Costa Ferreira A. M., Hureau C., Facchin G.
Inorganics 2024, 12(4), 97/1-5.
https://doi.org/10.3390/inorganics12040097
https://hal.science/hal-04669017
Restoring cellular copper homeostasis in Alzheimer disease: a novel peptide shuttle is internalized by an ATP-dependent endocytosis pathway involving Rab5- and Rab14-endosomes
Okafor M., Champomier O., Raibaut L., Ozkan S., El Kholti N., Ory S., Chasserot-Golaz S., Gasman S., Hureau C., Faller P., Vitale N.
Frontiers in Molecular Biosciences 2024, 11, 1355963/1-15.
https://doi.org/10.3389/fmolb.2024.1355963
https://hal.science/hal-04668999
Rationally designed Cu(I) ligand to prevent CuAβ-generated ROS production in the Alzheimer’s disease context
Rulmont C., Stigliani J.-L., Hureau C., Esmieu C.
Inorganic Chemistry 2024, 63(5), 2340-2351.
https://doi.org/10.1021/acs.inorgchem.3c02693
https://hal.science/hal-04669002
2023
Effect of metal environment and immobilization on the catalytic activity of a Cu superoxide dismutase mimic
Richezzi M., Ferreyra J., Signorella S., Palopoli C., Terrestre G., Pellegri N., Hureau C., Signorella S. R.
Inorganics 2023, 11(11), 425/1-19.
https://doi.org/10.3390/inorganics11110425
https://hal.science/hal-04301970
Synthesis, characterization, and biological properties of the copper(II) complexes with novel ligand: N-[4-({2-[1-(pyridin-2-yl)ethylidene]hydrazinecarbothioyl}amino)phenyl]acetamide
Rusnac R., Garbuz O., Chumakov Y., Tsapkov V., Hureau C., Istrati D., Gulea A.
Inorganics 2023, 11(10), 408/1-17.
https://doi.org/10.3390/inorganics11100408
https://hal.science/hal-04302011
Reduced Schiff-base derivatives to stop reactive oxygen species production by the Cu(Aβ) species: a structure–activity relationship
Lefèvre M., Lantigner L., Andolfo L., Vanucci-Bacqué C., Benoist E., Esmieu C., Bedos-Belval F., Hureau C.
Comptes Rendus Chimie 2023, 26(S3), 1-11.
https://doi.org/10.5802/crchim.255
https://hal.science/hal-04299723
LPMO-like activity of bioinspired copper complexes: from model substrate to extended polysaccharides
Leblay R., Delgadillo-Ruiz R., Decroos C., Hureau C., Réglier M., Castillo Pérez I., Faure B., Simaan A. J.
ChemCatChem 2023, 15(23), e202300933/1-9.
https://doi.org/10.1002/cctc.202300933
https://hal.science/hal-04231361
Interfacial behaviour of oligodeoxynucleotides prone to G-quadruplex formation on negatively charged electrode surface monitored by electrochemical probes
Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Renciuk D., Mergny J.-L., Fojta M.
Electrochimica Acta 2023, 442, 141878/1-8.
https://doi.org/10.1016/j.electacta.2023.141878
https://hal.science/hal-04232807
Redox processes in Cu-binding proteins: the “in-between” states in intrinsically disordered peptides
Falcone E., Hureau C.
Chemical Society Reviews 2023, 52(19), 6595-6600.
http://dx.doi.org/10.1039/D3CS00443K
https://hal.science/hal-04231237
Can the level of copper in the hippocampus witness type-II diabetes versus Alzheimer’s disease?
Hureau C.
eBioMedicine 2023, 87, 104403/1-2.
https://doi.org/10.1016/j.ebiom.2022.104403
https://hal.science/hal-04231411
The critical role of ligand flexibility on the activity of free and immobilized Mn superoxide dismutase mimics
Richezzi M., Signorella S., Palopoli C., Pellegri N., Hureau C., Signorella S. R.
Inorganics 2023, 11(9), 359/1-22.
https://doi.org/10.3390/inorganics11090359
https://hal.science/hal-04231291
Biomimetic catalysis of nitrite reductase enzyme using copper complexes in chemical and electrochemical reduction of nitrite
Ferreira M. P., Castro C. B., Honorato J., He S.-Y., Gonçalves Guimarães Júnior W., Esmieu C., Castellano E. E., de Moura A. F., Truzzi D. R., Nascimento O. R., Simonneau A., Marques Netto C. G. C.
Dalton Transactions 2023, 52(32), 11254-11264.
http://dx.doi.org/10.1039/D3DT01091K
https://hal.science/hal-04197074
Oxidative damages on the Alzheimer’s related-Aβ peptide alters its ability to assemble
Cheignon C., Collin F., Sabater L., Hureau C.
Antioxidants 2023, 12(2), 472/1-20.
https://doi.org/10.3390/antiox12020472
https://hal.science/hal-03988839
Ability of azathiacyclen ligands to stop Cu(Aβ)-induced production of reactive oxygen species: [3N1S] is the right donor set
Malikidogo K. P., Drommi M., Atrián-Blasco E., Hormann J., Kulak N., Esmieu C., Hureau C.
Chemistry – A European Journal 2023, 29(14), e202203667/1-11.
https://doi.org/10.1002/chem.202203667
https://hal.archives-ouvertes.fr/hal-03931017
2022
Development of Cu(ii)-specific peptide shuttles capable of preventing Cu–amyloid beta toxicity and importing bioavailable Cu into cells
Okafor M., Gonzalez P., Ronot P., El Masoudi I., Boos A., Ory S., Chasserot-Golaz S., Gasman S., Raibaut L., Hureau C., Vitale N., Faller P.
Chemical Science 2022, 13(40), 11829-11840.
http://dx.doi.org/10.1039/D2SC02593K
https://hal.science/hal-03876781
Synthesis, characterization and superoxide dismutase activity of a biomimetic Mn(III) complex covalently anchored to mesoporous silica
Richezzi M., Palopoli C., Pellegri N., Hureau C., Signorella S. R.
Journal of Inorganic Biochemistry 2022, 237, 112026/1-10.
https://doi.org/10.1016/j.jinorgbio.2022.112026
https://hal.science/hal-04669029
Improved emission of Yb(iii) ions in triazacyclononane-based macrocyclic ligands compared to cyclen-based ones
Kiraev S. R., Mathieu E., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
Dalton Transactions 2022, 51(43), 16596-16604.
http://dx.doi.org/10.1039/D2DT02266D
https://hal.science/hal-04297267
Sensitization pathways in NIR-emitting Yb(III) complexes bearing 0, +1, +2, or +3 charges
Mathieu E., Kiraev S. R., Kovacs D., Wells J. A. L., Tomar M., Andres J., Borbas K. E.
Journal of the American Chemical Society 2022, 144(46), 21056-21067.
https://doi.org/10.1021/jacs.2c05813
https://hal.science/hal-04297298
Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
Amrane S., Jaubert C., Bedrat A., Rundstadler T., Recordon-Pinson P., Aknin C., Guédin A., De Rache A., Bartolucci L., Diene I., Lemoine F., Gascuel O., Pratviel G., Mergny J.-L., Andreola M.-L.
Nucleic Acids Research 2022, 50(21), 12328-12343.
https://doi.org/10.1093/nar/gkac1030
https://hal.science/hal-03874577
Sequence–activity relationship of ATCUN peptides in the context of Alzheimer’s disease
Lefèvre M., Malikidogo K. P., Esmieu C., Hureau C.
Molecules 2022, 27(22), 7903/1-17.
https://doi.org/10.3390/molecules27227903
https://hal.archives-ouvertes.fr/hal-03875481
Synthesis, structure, and biologic activity of some copper, nickel, cobalt, and zinc complexes with 2-formylpyridine N4-allylthiosemicarbazone
Graur V., Chumakov Y., Garbuz O., Hureau C., Tsapkov V., Gulea A.
Bioinorganic Chemistry and Applications 2022, 2022, 2705332/1-18.
https://doi.org/10.1155/2022/2705332
https://hal.archives-ouvertes.fr/hal-03807954
Why the Ala-His-His peptide is an appropriate scaffold to remove and redox silence copper ions from the Alzheimer’s-related Aβ peptide
Gonzalez P., Sabater L., Mathieu E., Faller P., Hureau C.
Biomolecules 2022, 12(10), 1327/1-14.
https://doi.org/10.3390/biom12101327
https://hal.archives-ouvertes.fr/hal-03799992
Versatile activity of a copper(II) complex bearing a N4-tetradentate schiff base ligand with reduced oxygen species
Richezzi M., Ferreyra J., Puzzolo J., Milesi L., Palopoli C. M., Moreno D. M., Hureau C., Signorella S. R.
European Journal of Inorganic Chemistry 2022, (8), e202101042/1-11.
https://doi.org/10.1002/ejic.202101042
https://hal.archives-ouvertes.fr/hal-03549477
Role of Metal Ions in Alzheimer’s Disease: Mechanistic Aspects Contributing to Neurotoxicity
Hureau C.
in Alzheimer’s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities Govindaraju T. (Ed.). The Royal Society of Chemistry: Cambridge, 2022, pp. 170-192. (978-1-83916-230-5).
https://doi.org/10.1039/9781839162732-00170
https://hal.archives-ouvertes.fr/hal-03528657
Keggin-type polyoxometalates as Cu(II) chelators in the context of Alzheimer’s disease
Atrián-Blasco E., de Cremoux L., Lin X., Mitchell-Heggs R., Sabater L., Blanchard S., Hureau C.
Chemical Communications 2022, 58(14), 2367-2370.
http://dx.doi.org/10.1039/D1CC05792H
https://hal.archives-ouvertes.fr/hal-03547481
2021
The aggregation pattern of Aβ1–40 is altered by the presence of N-truncated Aβ4–40 and/or CuII in a similar way through ionic interactions
Stefaniak E., Atrian-Blasco E., Goch W., Sabater L., Hureau C., Bal W.
Chemistry – A European Journal 2021, 27(8), 2798-2809.
https://doi.org/10.1002/chem.202004484
https://hal.archives-ouvertes.fr/hal-03203165v1
Copper imbalance in Alzheimer’s disease and its link with the amyloid hypothesis: Towards a combined clinical, chemical, and genetic etiology
Squitti R., Faller P., Hureau C., Granzotto A., White A. R., Kepp K. P.
Journal of Alzheimer’s Disease 2021, 83(1), 23-41.
https://doi.org/10.3233/jad-201556
https://hal.archives-ouvertes.fr/hal-03331612
Synthetic polypeptide polymers as simplified analogues of antimicrobial peptides
Salas-Ambrosio P., Tronnet A., Verhaeghe P., Bonduelle C.
Biomacromolecules 2021, 22(1), 57-75.
https://doi.org/10.1021/acs.biomac.0c00797
https://hal.archives-ouvertes.fr/hal-02931945
Concentration-dependent interactions of amphiphilic PiB- derivative metal complexes with amyloid peptides Aβ and amylin
Majdoub S., Garda Z., Oliveira A. C., Relich I., Pallier A., Lacerda S., Hureau C., Geraldes C. F. G. C., Morfin J.-F., Tóth É.
Chemistry – A European Journal 2021, 27, 2009-2020.
https://doi.org/10.1002/chem.202004000
https://hal.archives-ouvertes.fr/hal-03011656
SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction
Lavigne M., Helynck O., Rigolet P., Boudria-Souilah R., Nowakowski M., Baron B., Brülé S., Hoos S., Raynal B., Guittat L., Beauvineau C., Petres S., Granzhan A., Guillon J., Pratviel G., Teulade-Fichou M.-P., England P., Mergny J.-L., Munier-Lehmann H.
Nucleic Acids Research 2021, 49(13), 7695-7712.
https://doi.org/10.1093/nar/gkab571
https://hal.archives-ouvertes.fr/hal-03281130
Synthesis, characterization, and biological activity of novel 3d metal coordination compounds with 2-acetylpyridine N4-allyl-S-methylisothiosemicarbazone
Graur V., Usataia I., Bourosh P., Kravtsov V., Garbuz O., Hureau C., Gulea A.
Applied Organometallic Chemistry 2021, 35(4), e6172/1-17.
https://doi.org/10.1002/aoc.6172
https://hal.archives-ouvertes.fr/hal-03412897
Reproducibility problems of amyloid-β self-assembly and how to deal with them
Faller P., Hureau C.
Frontiers in chemistry 2021, 8611227/1-7.
https://doi.org/10.3389/fchem.2020.611227
https://hal.archives-ouvertes.fr/hal-03203136
Impact of N-truncated Aβ peptides on Cu- and Cu(Aβ)-generated ROS: CuI matters!
Esmieu C., Ferrand G., Borghesani V., Hureau C.
Chemistry – A European Journal 2021, 27(5), 1777-1786.
https://doi.org/10.1002/chem.202003949
https://hal.archives-ouvertes.fr/hal-03383515
Unexpected trends in copper removal from Aβ peptide: when less ligand is better and Zn helps
Esmieu C., Balderrama-Martínez-Sotomayor R., Conte-Daban A., Iranzo O., Hureau C.
Inorganic Chemistry 2021, 60(2), 1248-1256.
https://doi.org/10.1021/acs.inorgchem.0c03407
https://hal.archives-ouvertes.fr/hal-03203129
Hybrid bis-histidine phenanthroline-based ligands to lessen Aβ-bound Cu ROS production: An illustration of Cu(I) significance
Drommi M., Rulmont C., Esmieu C., Hureau C.
Molecules 2021, 26(24), 7630/1-15.
https://doi.org/10.3390/molecules26247630
https://hal.archives-ouvertes.fr/hal-03547406
Voltammetric studies of selected porphyrin G-quadruplex ligands and their interaction with DNA in solution and at the mercury electrode surface
Dobrovodsky D., Danhel A., Mothes-Martin E., Pratviel G., Mergny J.-L., Fojta M.
Electrochimica Acta 2021, 394, 139151/1-11.
https://doi.org/10.1016/j.electacta.2021.139151
https://hal.archives-ouvertes.fr/hal-03357381
Measurement of interpeptidic CuII exchange rate constants of CuII-Amyloid-β complexes to small peptide motifs by tryptophan fluorescence quenching
Beuning C. N., Zocchi L. J., Malikidogo K. P., Esmieu C., Dorlet P., Crans D. C., Hureau C.
Inorganic Chemistry 2021, 60(11), 7650-7659.
https://doi.org/10.1021/acs.inorgchem.0c03555
https://hal.archives-ouvertes.fr/hal-03380483
Solid-state and solution characterizations of [(TMPA)Cu(II)(SO3)] and [(TMPA)Cu(II)(S2O3)] complexes: Application to sulfite and thiosulfate fast detection
Berthonnaud L., Esmieu C., Mallet-Ladeira S., Hureau C.
Journal of Inorganic Biochemistry 2021, 225, 111601/1-9.
https://doi.org/10.1016/j.jinorgbio.2021.111601
https://hal.archives-ouvertes.fr/hal-03394471
A water-soluble peptoid chelator that can remove Cu2+ from amyloid-β peptides and stop the formation of reactive oxygen species associated with Alzheimer’s disease
Behar A. E., Sabater L., Baskin M., Hureau C., Maayan G.
Angewandte Chemie, International Edition 2021, 60(46), 24588-24597.
https://doi.org/10.1002/anie.202109758
https://hal.archives-ouvertes.fr/hal-03395343
Partenariats
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International collaborators
- N. A. Rey, Department of Chemistry, Pontifical Catholic University of Rio de Janeiro, Brazil
Study of thiosemicarbazone chelators
- S. Signorella, University of Rosario, Argentina
Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase and plant oxygen release center). Collaboration supported by the PICS program of CNRS for the 2016-2018 period.
- W. Bal, University of Wroclaw, Poland
Analytical studies of Cu(II) coordination to peptides and aggregation of truncated peptides.
- D. Valensin, University of Siena, Italy
Study of the coordination of Cu(II) ions to the α-synuclein protein involved in Parkinson’s disease.
- D. Crans, University of Colorado,
Kinetic studies of metal ion exchange between peptides. Collaboration supported by a Chateaubriand grant for C. Beuning.
- G. Maayan, Technion University, Israel.
Peptoid ligands as Cu(II) chelators in Alzheimer’s disease.
- M. Laguna, ISQCH, University of Saragossa, Spain
Study of Cu(I) chelators
- A. Gulea and V. Graur, State University of Moldova, Moldova
EPR studies of Cu(II) – thiosemicarbazone derivatives
- N. Wezynfeld, Warsaw University of Technology, Poland
Study of phosphorylated amyloid peptides
- F. Stellato, University of Rome Tor Vergata, Italy
Study of metal complexes by XAS spectroscopy
- J. Platts, University of Cardiff, UK
Computational studies of amyloid peptides
French Collaborators
- K. Reybier, IRD, University of Toulouse
Study of oxidative stress generated by Cu(Aβ) on cells.
- P. Genevaux, Laboratory of Microbiology and Molecular Genetics, Toulouse.
Study of chaperone proteins of amyloid-β peptide aggregation.
- E. Anxolabéhère-Mallart, University D. Diderot, Paris
Studies of Mn complexes, enzyme mimes (catalase and superoxide dismutase)
- P. Delangle, Ion Recognition and Coordination Chemistry Laboratory, CEA Grenoble
Study of Cu(I/II) chelators in the context of Alzheimer’s disease
- C. Policar, ENS Ulm, Paris
Study of SOD mimics against oxidative stress in Alzheimer’s disease.
- N. Delsuc, ENS Ulm, Paris
Study of Cu(II) peptide complexes with SOD activity
- R. Tripier and Dr. Maryline Beyler, UMR 6521, Université de Bretagne Occidentale.
Study of macrocyclic Cu(II) chelators in the context of Alzheimer’s disease.
- O. Iranzo, Institute of Molecular Sciences of Marseille, UMR 7313, University of Aix – Marseille.
Study of pseudo-peptide chelators of Cu(II) in the context of Alzheimer’s disease.
- P. Faller, Institut de Chimie de Strasbourg, UMR7177
Traceable Cu(II) metallophores as a therapeutic approach in Alzheimer’s disease.
- S. Blanchard, Institut Parisien de Chimie Moléculaire, UMR 8232
Study of polyoxometallates in Alzheimer’s disease.
- S. Hamdi, Human Fertility Research Group, EA 3694 of Paul-Sabatier University
Study of the role of metal ions in the aggregation of SEMS peptides involved in fertility
- E. Toth, Molecular Biophysics Center, UPR 4301, Orléans.
Markers of amylin aggregation involved in type II diabetes.
- M. Blanchard, Geosciences Environnement Toulouse, Observatoire Midi-Pyrénées.
Use of stable isotopes of Cu and Zn ions to study Aβ assembly.
- O. Maury, F. Riobé, Chemistry Laboratory, ENS Lyon
Complexes for modulation and monitoring of amyloid aggregation.
- G. Lippens, LISBP, INSA-Toulouse
Study of phosphorus chaperones of Tau proteins
- O. Cuvillier, IPBS, UMR 5089
Study of cytotoxicity of Cu(Aβ) and restoration of cell survival.
- E. Benoist, SPCMIB, UMR 5068
Re(CO)3 complexes for amyloid imaging.
- N. Giraud, Université de Paris, UMR CNRS 8601
NMR study of Aβ interaction with external partners.
- F. Bedos and C. Bacqué, SPCMIB, UMR 5068
(Clickable) ligands targeting Cu(II) in the Alzheimer’s context.
- S. Begin-Colin, ICPEES, Université de Strasbourg
Etude de nanoparticules d’oxide de fer comme sondes de l’assemblage du peptide amyloïde-beta.
Financements
Cliquez-ici pour consulter les financeurs
PuLCO, ANR, 2025-2028
Approche multidisciplinaire sur des métalloenzymes à cuivre pour améliorer l’utilisation des polysaccharides récalcitrants.
PI : Christelle Hureau
Read more: ANR PuLCO
LPMO-PEPS, ANR, 2024-2028
Modélisation structurelle et fonctionnelle du LPMO à l’aide de complexes peptide-cuivre
PI : Christelle Hureau
Read more: ANR LPMO-PEPS
CAPES-COFECUB, 2024-2028
Evaluation et étude mécanistiques de nouveaux métallophores hydrazoniques dans le contexte de la maladie d’Alzheimer
PI : Charlène Esmieu, Christelle Hureau
LnZYME, ANR, 2023-2028
Lanthano-peptides as mimics of lanthanide methanol dehydrogenase enzyme
PI : Emilie Mathieu
Read more: ANR LnZYME
Amyl-in-AD, MITI CNRS, 2023-2026
Is amylin the real villain in Alzheimer’s disease ?
PI : Christelle Hureau & Nicolas Vitale
MASAI, ANR, 2022-2026
Metal-based agents for selective amyloid imaging.
PI : Eva Tòth, Partner : Christelle Hureau
Read more: ANR MASAI
DREAMY, ANR, 2023-2027
Deciphering early steps of self-assembly of amyloid forming peptides
PI : Nicolas Giraud, Partner : Christelle Hureau
Read more: ANR DREAMY
SUPRAMY, ANR PRC, 2021-2025
Utilsation de polyanions pour moduler l’auto-assemblage de peptides impliqués dans des maladies amyloïdes
PI : Christelle Hureau
Read more: ANR SUPRAMY
COPPERATION, ANR JCJC, 2020-2024
Fluorescent ligands: for the rational design of ligands targeting copper ions in Alzheimer’s disease
PI : Charlène Esmieu
Read more: ANR COPPERATION
ANRS, Emerging infectious diseases, 2020 – 2023
Function and targeting of G-quadruplexes RNAs from HIV-1
PI : Dr Samir AMRANE (Institut Européen de Chimie Biologie, IECB, Bordeaux),
Partner: Geneviève Pratviel
DIVA, ANR, 2016 – 2021
Diabetes Imaging by Visualizing Amylin with Metal-based Probes
PI: Dr. E. Toth (CBM, Orléans), Partner: Christelle Hureau
Read more: ANR DIVA
CASPER, Fondation France-Alzheimer, 2016-2018
Dynamic Combinatorial Synthesis of Optical Molecular Markers of the Aggregated Amyloid-ß Peptide
PI: B. Mestre-Voegtlé
ALzINK, ERC (European Research Council) StG, 2015-2020
Alzheimer’s disease & Zinc : the missing link ?
PI: Christelle HUREAU
Read more: ERC ALZINK
AlzPEPS, Fellowship USIAS, 2015-2017
Peptides as Cu shuttles
PI: Christelle Hureau & Peter Faller (UMR 7177, Strasbourg)
Recoligo, France-Alzheimer, 2014-2017
Targeting amyloides-ß oligomers
PI: Christelle Hureau
AlzABox, ANR Blanc, 2013-2017
Oxidation of the Aβ peptide and consequences in the aetiology of Alzheimer’s Disease
PI: Fabrice Collin ; Partner: Christelle Hureau
Read more: ANR AlzaBox
Neurometals, ANR Blanc, 2009-2013
Impact of metallic ion in Alzheimer’s disease
PI: Peter Faller
Read more: ANR Neurometals
PICS, CNRS-CONICET, 2016-2018
Mn-based biosinpired Water-Oxidizing Complex
PI: Christelle Hureau
Alumnae
Cliquez-ici pour voir nos anciens doctorants
- Lucie de CREMOUX
2022-2025 – Study of peptides assembly with or without the addition of polyoxometalates or polyphosphates - Marielle DROMMI
2021-2024 – Design, synthesis and study of artificial metallopeptidases in the context of Alzheimer’s disease - Margot LEFEVRE
2021-2024 – Synthesis and studies of new inorganic pro-drugs based on hybrid organic/peptidic scaffold in the context of Alzheimer Disease - Clément RULMONT
2020-2023 – Synthesis of traceable copper I chelating ligand for chelation therapy in Alzheimer’s disease - Léonie BERTHONNAUD
2018-2022 – Elucidation of mechanisms at the origin of Alzheimer’s disease - Antoine TRONNET
2018-2022 – Polymeric analog of antimicrobial peptides with anti-Clostridium difficile therapeutic potential - Tiffany RUNDSTADLER
2018-2022 – G-quadruplex ligands of nucleic acids: modeling, synthesis and antiviral activity - Xudong LIN
2018-2022 – Synthesis and studies of compounds targeting the aggregation of amyloid-beta peptide - Raul BALDERRAMA
2019 – Peptidomimetic ligands for the chelation of Cu(II) - Ewelina STEFANIAK
2016-2017 – Coordination of Cu(II) ions to peptides for SOD activity - Amandine VINCENT
2018-2019 – Co-aggregation of amyloid peptides - Sara AYALA
2014-2018 – Role of Zn ions and chaperone proteins in the aggregation of different forms of amyloid-β peptide - Alexandre POCINHO
2014-2018 – Optimization of molecules for recognition of oligomeric forms of amyloid-β peptides - Valentina BORGHESANI
2015-2018 – Impact of Zn ions in the aggregation of different forms of amyloid-β peptide - Amandine CONTE-DABAN
2014-2017 – Role of Cu and Zn ions in the aggregation and toxicity of metal complexes of amyloid-β peptide: mechanistic and therapeutic aspects
LCC CNRS
Laboratoire de chimie de coordination du CNRS
205 route de Narbonne, BP 44099
31077 Toulouse cedex 4
France
+ 33 5 61 33 31 00
