Nuclear Magnetic Resonance (NMR)

LCC

Service overview

The mission of the NMR facility is to provide scientific and technical expertise in NMR spectroscopy and to provide users with open-access to a range of functional equipment. In particular, the facility carries out and interprets NMR spectra on specific problems. It can carry out detailed studies as part of scientific collaborations or service deliveries. It is also responsible for the maintenance of the spectrometers, training and assistance to users of open-access equipment.

The NMR service is open to researchers from outside the laboratory and from the private sector. The service is part of the “RMN Midi-PyrĂ©nĂ©es” network.

Service members

Ingénieur de Recherche

COPPEL Yannick
Ingénieur de Recherche

BIJANI Christian
IngĂ©nieur d’étude en chimie analytique

BONNET Antoine
MATUS Tetiana
Etudiante

MATUS Tetiana
PARYL David
Responsable informatique et technique du libre-service RMN

PARYL David
Ingénieur de Recherche

COPPEL Yannick

Numéro ORCID : 0000-0003-0970-4082

AprĂšs une formation universitaire en sciences chimiques, j’ai obtenu un doctorat de chimie (1996) au LEDSS de Grenoble (Etude RMN/modĂ©lisation molĂ©culaire d’interactions oligonuclĂ©otide abasique- ligands). J’ai ensuite effectuĂ© un post-doctorat (Prof.  Opella , UniversitĂ© de Pennsylvanie, Philadelphie, USA, 1997-98) portant sur l’étude RMN de la structure d’une protĂ©ine membranaire. En 1998, j’ai Ă©tĂ© recrutĂ© comme ingĂ©nieur de recherche CNRS pour prendre la responsabilitĂ© du service RMN du LCC.

Email:yannick.coppel(at)lcc-toulouse.fr

Téléphone:05.61.17.54.27

Bureau:IPBS 030

Ingénieur de Recherche

BIJANI Christian

Numéro ORCID : 0000-0003-3989-3021

AprÚs un Master 1 en chimie organique à Montpellier, Christian a effectué une thÚse CIFRE en collaboration entre une startup Bordelaise et le CBMN dirigé par Erick Dufourc. Son travail de Doctorat avait pour objectif la formulation de biomolécules et leur étude structurelle par RMN.
PassionnĂ© de RMN, c’est tout naturellement qu’il occupe actuellement un poste d’IngĂ©nieur de Recherche dans le service de RMN du LCC.
Domaines d’expertises : Maintenance, suivi et rĂ©alisation d’expĂ©riences RMN en accord avec les domaines de la chimie dĂ©veloppĂ©s au LCC et dans l’Institut de Chimie de Toulouse

Email:christian.bijani(at)lcc-toulouse.fr

Téléphone:05.61.17.54.27

Bureau:IPBS 030

IngĂ©nieur d’étude en chimie analytique

BONNET Antoine

Email:antoine.bonnet(at)lcc-toulouse.fr

Email libre-service:rmn-libre-service(at)lcc-toulouse.fr

Téléphone:05.61.17.54.30

Bureau:IPBS 033

Etudiante

MATUS Tetiana

Email:tetiana.matus(at)lcc-toulouse.fr

Téléphone:05.61.17.54.27

Bureau:IPBS

Responsable informatique et technique du libre-service RMN

PARYL David

Email:david.paryl(at)lcc-toulouse.fr

Téléphone:05.61.17.54.30

Bureau:IPBS 033

Equipments

4 NMR spectrometers Bruker in open-access

Bruker NMR spectrometers Avance 300, Avance 400, 2 Avance III 400 (PDF file), 3 of which are equipped with autosamplers. Realisation of 1D experiments (1H, 13C, 31P, 11B, …), 2D experiments (COSY, HMQC, HMBC, NOESY
) and variable temperature experiments.
Note the possibility of carrying out experiments with double decoupling: 13C with 1H and 31P decoupling, HMQC 1H-13C with 31P decoupling…).

More details

Bruker Avance III 400 Wide-Bore for solid-state NMR

Equipments:

  • 4mm triple resonance probe MAS H-F/X/Y with insert 31P / 65Cu – 29
  • 4mm double resonance probe MAS H/X low gamma (109Ag – 13C)
  • 2mm double resonance probe MAS H-F/X (15N – 31P)
  • 5mm double rĂ©sonance probe MAS H-F/X (13C – 31P)
  • 3mm double rĂ©sonance probe MAS H/X (15N – 31P)
  • 5mm goniometric probe H/X (15N – 31P)
  • Variable temperature unit (BCUII + Nitrogen exchanger)

Bruker Avance NEO for liquid or solid-state NMR

Equipments:

  • 5mm broadband inverse triple-resonance probe

1H, BB(31P-103Rh)/31P with Z field gradients

 

  • 2mm double resonance CPMAS H/X high gamma (31P – 15N)

 

  • 2mm double resonance CPMAS H/X low gamma (15N – 109Ag)

 

  • Variable temperature unit (BCUII and nitrogen vaporization)

Services

Application form for high-resolution liquid NMR experiments (Analyses RMN liquide)
Application form for solid-state NMR experiments (Analyses RMN solide)

Rates: Contact us

The service applies a certified full-cost pricing system that allows the invoicing of services in research projects financed by public third parties (ANR, EU, etc.).

Application fields

NMR (Nuclear Magnetic Resonance) is a non-destructive chemical analysis technique commonly used to determine the molecular composition and purity of a sample.

It allows the identification of molecules, the determination of their structure and the study of some of their physical properties in solution or in the solid state (change of conformation, phase, solubility, size…).

This facility offers a wide range of services that can be integrated into your R&D projects in a wide variety of scientific fields (materials, organic chemistry, catalysis, natural products, etc.). Today, we carry out NMR measurements for more than twenty public or industrial laboratories.

 The NMR facility can offer you solutions ranging from simple access to NMR spectrometers for routine controls to the complete handling of your samples by our engineers (preparation of samples for analysis, performance of measurements, interpretation of results, drafting of an analysis report, etc.). Any service will be subject to a detailed quote that we will draw up according to your needs.

Application examples:

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Monitoring of chemical syntheses

  • Chemical composition of a reaction mixture
  • Quality control of production
  • Detection and characterisation of impurities
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Determination of the molecular structure

  • Study of the three-dimensional shape of molecules
  • Identification of original molecules, bioactive molecules (antibiotics, antifungals…), natural products…
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Study of materials or insoluble products

  •  Crystalline (polymorphism) or amorphous form
  • Absorption of molecules on silicas, zeolites

  • Arrangement of molecules in the solid-state
  • Natural products (wood, bone…)
  • Gel, liquid crystals
  • Aging/modification of materials
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Study of dynamic phenomena

  • Study of reaction mechanisms (kinetic and thermodynamic study, reaction intermediates)
  • Isotope exchange
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Study of molecular interactions

  • Study of direct or reverse micelles, vesicles, liposomes
  • Study of association phenomena, aggregation, polymerisation

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Polymer study

  • Linear or branched form, in solution or solid state
  • Structure of the units
  • Polydispersity index
  • Average molecular weight and size

Feasible experiments

Liquid -state samples:

– A lot of different nucleus can be studied: 1H, 2H, 7Li, 11B, 13C, 15N, 19F, 27Al, 29Si, 31P, 51V, 103Rh, 109Ag, 113Cd, 119Sn, 195Pt…
– 1D and 2D triple-resonance experiment can be run: 1H/31P/X (X {1H, 31P}, 31P {1H, X} and 1H {31P, X}). In addition triple resonance experiment 1H/13C/X et 1H/13C/15N/2H can be done on the spectrometers of « Midi-PyrĂ©nĂ©es » NMR network.
– 1D multi-pulses experiments with gradient fields and selective pulses: DEPT, INEPT, T1 and T2  measurements, 1D TOCSY, 1D NOESY, 1D-HSQC, solvent suppression, 1D quantitative

– 2D homo- and hetero-nuclear experiment: COSY, NOESY, TOCSY, ROESY, EXY, HMQC, HSQC, HMBC, ADEQUATE

– 2D experiment with homonuclear 1H decoupling (pure-shift, psyche, ZS, HOBS
)
– DOSY experiment for self-diffusion coefficient measurement.
– Variable temperature (-100°C Ă  +100°C).

    Solid -state samples:

    – A lot of different nucleus can be studied: 1H, 2H, 11B, 13C, 15N, 17O, 19F, 29Si, 31P, 33S, 35Cl, 51V, 77Se, 79Br, 107Ag, 113Cd,…
    – Triple-resonance experiment can be run:  1H/31P/13C and 1H/19F/X
    – 1D experiments: 1H/19F-X CP et CP quantitative, X{1H} HPDEC, INEPT, spectral edition, X CPMG et CP-CPMG, REDOR
    – 2D experiments: 1H-19F/X HETCOR, HMQC, MQMAS, 2D DQMAS, NOESY-RFDR, 2D CRAMPS….
    – Study of dynamic phenomena: relaxation time measurement (T1, T2, T1ρ), dipolar coupling and CSA measurement…
    – Variable temperature (-60°C Ă  +100°C)

    Publications

    2023

    Knight Shift in C-13 NMR Resonances Confirms the Coordination of N-Heterocyclic Carbene Ligands to Water-Soluble Palladium Nanoparticles.
    Asensio, J.; Tricard, S.; Coppel, Y.; Andres, R.; Chaudret, B.; de Jesus, E., 
    Angewandte Chemie-International Edition 2017, 56 (3), 865-869.

    Amphiphilic polymeric nanoreactors containing Rh(I)-NHC complexes for the aqueous biphasic hydrogenation of alkenes.
    Sambou, S. S.; Hromov, R.; Ruzhylo, I.; Wang, H.; Allandrieu, A.; Sabatier, C.; Coppel, Y.; Daran, JC.; Gayet, F.; Labande, A.; Manoury, E.; Poli, R.,
    Catalysis Science & Technolog 2021, 11 (20), 6811-6824.
    https://doi.org/10.1039/D1CY00554E

     

    2022
    2021

    Trainings

    Within the framework of the « Midi-Pyrénées » NMR network, we offer two NMR training courses through the « CNRS Formation Entreprise » organization (in French):
    NMR analysis: acquisition, processing and interpretation (NMR analysis)
    NMR for chemistry and biochemistry: advanced (advanced)

    Each year, the NMR facility provides NMR training to the doctoral school of material sciences at the Paul Sabatier University of Toulouse (in English).

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    LCC

    Laboratoire de chimie de coordination du CNRS

    205 route de Narbonne, BP 44099
    31077 Toulouse cedex 4
    France

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    + 33 5 61 33 31 00

    Contact