Nuclear Magnetic Resonance (NMR)


Service overview

The mission of the NMR facility is to provide scientific and technical expertise in NMR spectroscopy and to provide users with open-access to a range of functional equipment. In particular, the facility carries out and interprets NMR spectra on specific problems. It can carry out detailed studies as part of scientific collaborations or service deliveries. It is also responsible for the maintenance of the spectrometers, training and assistance to users of open-access equipment.

The NMR service is open to researchers from outside the laboratory and from the private sector. The service is part of the “RMN Midi-Pyrénées” network.

Service members

COPPEL Yannick
Ingénieur de Recherche

COPPEL Yannick

Ingénieur d’étude en chimie analytique

BONNET Antoine

Ingénieur de Recherche

BIJANI Christian

Responsable informatique et technique du libre-service RMN


Ingénieur de Recherche

COPPEL Yannick

Numéro ORCID : 0000-0003-0970-4082

Après une formation universitaire en sciences chimiques, j’ai obtenu un doctorat de chimie (1996) au LEDSS de Grenoble (Etude RMN/modélisation moléculaire d’interactions oligonucléotide abasique- ligands). J’ai ensuite effectué un post-doctorat (Prof.  Opella , Université de Pennsylvanie, Philadelphie, USA, 1997-98) portant sur l’étude RMN de la structure d’une protéine membranaire. En 1998, j’ai été recruté comme ingénieur de recherche CNRS pour prendre la responsabilité du service RMN du LCC.

Ingénieur d’étude en chimie analytique

BONNET Antoine

Ingénieur de Recherche

BIJANI Christian

Numéro ORCID : 0000-0003-3989-3021

Après un Master 1 en chimie organique à Montpellier, Christian a effectué une thèse CIFRE en collaboration entre une startup Bordelaise et le CBMN dirigé par Erick Dufourc. Son travail de Doctorat avait pour objectif la formulation de biomolécules et leur étude structurelle par RMN.
Passionné de RMN, c’est tout naturellement qu’il occupe actuellement un poste d’Ingénieur de Recherche dans le service de RMN du LCC.
Domaines d’expertises : Maintenance, suivi et réalisation d’expériences RMN en accord avec les domaines de la chimie développés au LCC et dans l’Institut de Chimie de Toulouse

Responsable informatique et technique du libre-service RMN



4 NMR spectrometers Bruker in open-access

Bruker NMR spectrometers Avance 300, Avance 400, 2 Avance III 400 (PDF file), 3 of which are equipped with autosamplers. Realisation of 1D experiments (1H, 13C, 31P, 11B, …), 2D experiments (COSY, HMQC, HMBC, NOESY…) and variable temperature experiments.
Note the possibility of carrying out experiments with double decoupling: 13C with 1H and 31P decoupling, HMQC 1H-13C with 31P decoupling…).

Bruker Avance III 400 Wide-Bore for solid-state NMR

Bruker Avance NEO for liquid or solid-state NMR


  • 5mm broadband inverse triple-resonance probe

1H, BB(31P-103Rh)/31P with Z field gradients


  • 2mm double resonance CPMAS H/X high gamma (31P – 15N)


  • 2mm double resonance CPMAS H/X low gamma (15N – 109Ag)


  • Variable temperature unit (BCUII and nitrogen vaporization)


Application form for high-resolution liquid NMR experiments (Analyses RMN liquide)
Application form for solid-state NMR experiments (Analyses RMN solide)

Rates: Contact us

The service applies a certified full-cost pricing system that allows the invoicing of services in research projects financed by public third parties (ANR, EU, etc.).

Application fields

NMR (Nuclear Magnetic Resonance) is a non-destructive chemical analysis technique commonly used to determine the molecular composition and purity of a sample.

It allows the identification of molecules, the determination of their structure and the study of some of their physical properties in solution or in the solid state (change of conformation, phase, solubility, size…).

This facility offers a wide range of services that can be integrated into your R&D projects in a wide variety of scientific fields (materials, organic chemistry, catalysis, natural products, etc.). Today, we carry out NMR measurements for more than twenty public or industrial laboratories.

 The NMR facility can offer you solutions ranging from simple access to NMR spectrometers for routine controls to the complete handling of your samples by our engineers (preparation of samples for analysis, performance of measurements, interpretation of results, drafting of an analysis report, etc.). Any service will be subject to a detailed quote that we will draw up according to your needs.

Application examples:

Monitoring of chemical syntheses

  • Chemical composition of a reaction mixture
  • Quality control of production
  • Detection and characterisation of impurities

Determination of the molecular structure

  • Study of the three-dimensional shape of molecules
  • Identification of original molecules, bioactive molecules (antibiotics, antifungals…), natural products…

Study of materials or insoluble products

  •  Crystalline (polymorphism) or amorphous form
  • Absorption of molecules on silicas, zeolites…
  • Arrangement of molecules in the solid-state
  • Natural products (wood, bone…)
  • Gel, liquid crystals
  • Aging/modification of materials

Study of dynamic phenomena

  • Study of reaction mechanisms (kinetic and thermodynamic study, reaction intermediates)
  • Isotope exchange

Study of molecular interactions

  • Study of direct or reverse micelles, vesicles, liposomes
  • Study of association phenomena, aggregation, polymerisation…

Polymer study

  • Linear or branched form, in solution or solid state
  • Structure of the units
  • Polydispersity index
  • Average molecular weight and size

Feasible experiments

Liquid -state samples:

– A lot of different nucleus can be studied: 1H, 2H, 7Li, 11B, 13C, 15N, 19F, 27Al, 29Si, 31P, 51V, 103Rh, 109Ag, 113Cd, 119Sn, 195Pt…
– 1D and 2D triple-resonance experiment can be run: 1H/31P/X (X {1H, 31P}, 31P {1H, X} and 1H {31P, X}). In addition triple resonance experiment 1H/13C/X et 1H/13C/15N/2H can be done on the spectrometers of « Midi-Pyrénées » NMR network.
– 1D multi-pulses experiments with gradient fields and selective pulses: DEPT, INEPT, T1 and T2  measurements, 1D TOCSY, 1D NOESY, 1D-HSQC, solvent suppression, 1D quantitative…
– 2D homo- and hetero-nuclear experiment: COSY, NOESY, TOCSY, ROESY, EXY, HMQC, HSQC, HMBC, ADEQUATE…
– 2D experiment with homonuclear 1H decoupling (pure-shift, psyche, ZS, HOBS…)
– DOSY experiment for self-diffusion coefficient measurement.
– Variable temperature (-100°C à +100°C).

    Solid -state samples:

    – A lot of different nucleus can be studied: 1H, 2H, 11B, 13C, 15N, 17O, 19F, 29Si, 31P, 33S, 35Cl, 51V, 77Se, 79Br, 107Ag, 113Cd,…
    – Triple-resonance experiment can be run:  1H/31P/13C and 1H/19F/X
    – 1D experiments: 1H/19F-X CP et CP quantitative, X{1H} HPDEC, INEPT, spectral edition, X CPMG et CP-CPMG, REDOR
    – 2D experiments: 1H-19F/X HETCOR, HMQC, MQMAS, 2D DQMAS, NOESY-RFDR, 2D CRAMPS….
    – Study of dynamic phenomena: relaxation time measurement (T1, T2, T), dipolar coupling and CSA measurement…
    – Variable temperature (-60°C à +100°C)


    View the publications


    Within the framework of the « Midi-Pyrénées » NMR network, we offer two NMR training courses through the « CNRS Formation Entreprise » organization (in French):
    NMR analysis: acquisition, processing and interpretation (NMR analysis)
    NMR for chemistry and biochemistry: advanced (advanced)

    Each year, the NMR facility provides NMR training to the doctoral school of material sciences at the Paul Sabatier University of Toulouse (in English).


    Laboratoire de chimie de coordination du CNRS

    205 route de Narbonne, BP 44099
    31077 Toulouse cedex 4

    + 33 5 61 33 31 00