Fluorine makes the difference—Gold(I)-NHC complexes with fluoroaryl substituents exhibit highly potent antileishmanial activity
Ftouh S., Bourgeade-Delmas S., Salis C., Stigliani J.-L., Litot C., Villarubias T., Terrisse A.-D., Royo J., Liang Z., Fabre N., Vansteelandt M., Iriart X., Carraz M., Deraeve C., Hemmert C., Reybier K., Valentin A., Gornitzka H.
Chem. – Eur. J. 2026, 32(39), e71382/1-10.
10.1002/chem.71382 – hal-05826174

Molecular dynamics and quantum chemical insights into the molecular basis of differential toxicity of the mycotoxin Deoxynivalenol (DON) and its microbial derivatives DOM-1 and 3-epi-DON
Lal K., Vignard J., Mirey G., Jolibois F., Oswald I. P., Stigliani J.-L.
ACS Omega 2026, 11(6), 9575-9586.
10.1021/acsomega.5c09756 – hal-05495502

Current state of the art of gold complexes as antileishmanial agents
Hemmert C., Gornitzka H., Deraeve C., Stigliani J.-L.
Coord. Chem. Rev. 2025, 528, 216408.
10.1016/j.ccr.2024.216408 – hal-05346060v1

New cyclopeptide and γ-butyrolactone derivatives from an endophytic strain of Cophinforma mamane
Litot C., Vansteelandt M., Ortiz S., Barakat F., Crossay E., Titton D., Bourgeade-Delmas S., Amasifuen C., Graton J., Jacquemin D., Stigliani J.-L., Haddad M., Fabre N.
ACS Omega 2025, 10(21), 21738-21746.
10.1021/acsomega.5c01292 – hal-05121071

Mechanochemistry to form substituted imidazoles, imidazolium salts and NHC–Gold complexes with fluorine-containing groups
Salis C., Mohammedi S., Turazza L., Blandin Y., Garnier M., Hemmert C., Baltas M., Gornitzka H.
Molecules 2025, 30(3), 522/1-16.
10.3390/molecules30030522 – hal-04931989

Electrophilic behavior of the “nucleophilic” pyramidane: reactivity of Ge-pyramidane towards organolithium reagents
Lee V. Y., Wang J., Sasamori T., Gapurenko O. A., Minyaev R. M., Minkin V. I., Takeuchi K., Fukaya N., Gornitzka H.
Chemistry – A European Journal 2024, 30(45), e202401806/1-5.
https://doi.org/10.1002/chem.202401806
https://hal.science/hal-04804011

Mono- and Dinuclear 1-(2-Pyridyl)-4-phenyl-1,2,3-triazole-Based Ir(III) and Rh(III) Complexes
Moreno-Latorre M., de la Torre M. C., Gornitzka H., Hemmert C., Sierra M. A.
Organometallics 2024, 43(10), 1128-1136.
https://doi.org/10.1021/acs.organomet.4c00079
https://hal.science/hal-04669053

Rationally designed Cu(I) ligand to prevent CuAβ-generated ROS production in the Alzheimer’s disease context
Rulmont C., Stigliani J.-L., Hureau C., Esmieu C.
Inorganic Chemistry 2024, 63(5), 2340-2351.
https://doi.org/10.1021/acs.inorgchem.3c02693
https://hal.science/hal-04669053

X-ray Crystallography of Organogermanium Compounds
Hemmert C., Gornitzka H.
in Organogermanium Compounds, V. Y. Lee (Ed.), John Wiley & Sons: Hoboken, 2023, vol. 2, pp. 667-743. (978-1-1196-1352-7).
https://doi.org/10.1002/9781119613466.ch16
https://hal.science/hal-04244894

Pharmacological characterization of [¹⁸F]-FNM and evaluation of NMDA receptors activation in a rat brain injury model
Beaurain M., Talmont F., Pierre D., Péran P., Boucher S., Hitzel A., Rols M.-P., Cuvillier O., Payoux P., Salabert A.-S.
Molecular Imaging and Biology 2023, 25(4), 692-703.
https://doi.org/10.1007/s11307-023-01811-y
https://hal.science/hal-04244094

Hybrid bicyclo[1.1.0]butanes [(R₄Si₃)CH₂] and [(R₄Si₂Ge)CH₂] (R = SiMe^tBu₂): Synthesis and thermal isomerization to alkyl-substituted cyclopropenes [R₃Si₃]CH₂R and [R₃Si₂Ge]CH₂R
Lee V. Y., Yasuda H., Gapurenko O. A., Minyaev R. M., Gornitzka H., Sekiguchi A.
Organometallics 2023, 42(18), 2514-2521.
https://doi.org/10.1021/acs.organomet.2c00599
https://hal.science/hal-04175751

Daphnanes diterpenes from the latex of Hura crepitans L. and their PKCζ-dependent anti-proliferative activity on colorectal cancer cells
Crossay E., Jullian V., Trinel M., Sagnat D., Hamel D., Groppi E., Rolland C., Stigliani J.-L., Mejia K., Cabanillas B. J., Alric L., Buscail E., El Kalamouni C., Mavingui P., Deraison C., Racaud-Sultan C., Fabre N.
Bioorganic & Medicinal Chemistry 2023, 90, 117366/1-17.
https://doi.org/10.1016/j.bmc.2023.117366
https://hal.science/hal-04244338

N-heterocyclic carbene-iridium complexes as photosensitizers for in vitro photodynamic therapy to trigger non-apoptotic cell death in cancer cells
Wang X., Zhang C., Madji R., Voros C., Mazères S., Bijani C., Deraeve C., Cuvillier O., Gornitzka H., Maddelein M.-L., Hemmert C.
Molecules 2023, 28(2), 691/1-29.
https://doi.org/10.3390/molecules28020691
https://hal.science/hal-03870710

Sphingosine kinase-1 is overexpressed and correlates with hypoxia in osteosarcoma: Relationship with clinicopathological parameters
Gomez-Brouchet A., Illac C., Ledoux A., Fortin P.-Y., de Barros S., Vabre C., Despas F., Peries S., Casaroli C., Bouvier C., Aubert S., de Pinieux G., Larousserie F., Galmiche L., Talmont F., Pitson S., Maddelein M.-L., Cuvillier O.
Cancers 2022, 14 (3), 499/1-17.
https://doi.org/10.3390/cancers14030499
https://hal.science/hal-03312272v2

Sphingosine 1-phosphate receptor 5 (S1P5) deficiency promotes proliferation and immortalization of mouse embryonic fibroblasts
Talmont F., Mitri E., Dozier C., Besson A., Cuvillier O., Hatzoglou A.
Cancers 2022, 14 (7), 1661/1-20.
https://doi.org/10.3390/cancers14071661
https://hal.science/hal-03808905v1

Shvo-type metal–ligand cooperative catalysts: Tethered η⁵-oxocyclohexadienyl ruthenium complexes
Puig E., Verron R., Kechaou-Perrot M., Vendier L., Gornitzka H., Miqueu K., Sotiropoulos J.-M., Fischmeister C., Sutra P., Igau A.
Organometallics 2022, 41(11), 1391-1402.
https://doi.org/10.1021/acs.organomet.2c00123
https://hal.archives-ouvertes.fr/hal-03715383

Pd-catalyzed C–C and C–N cross-coupling reactions in 2-aminothieno[3,2-d]pyrimidin-4(3H)-one series for antiplasmodial pharmacomodulation
Mustière R., Lagardère P., Hutter S., Deraeve C., Schwalen F., Amrane D., Masurier N., Azas N., Lisowski V., Verhaeghe P., Mazier D., Vanelle P., Primas N.
RSC Advances 2022, 12(31), 20004-20021.
http://dx.doi.org/10.1039/D2RA01687G
https://hal.archives-ouvertes.fr/hal-03726141

Investigation of direct and retro chromone-2-carboxamides based analogs of Pseudomonas aeruginosa quorum sensing signal as new anti-biofilm agents
Trognon J., Vera G., Rima M., Stigliani J.-L., Amielet L., El Hage S., Lajoie B., Roques C., El Garah F.
Pharmaceuticals 2022, 15(4), 417/1-26.
https://doi.org/10.3390/ph15040417
https://hal.archives-ouvertes.fr/hal-03669961

1-Chloroalumole
Lee V. Y., Sugasawa H., Gapurenko O. A., Minyaev R. M., Minkin V. I., Gornitzka H., Sekiguchi A.
Organometallics 2022, 41(4), 467-471.
https://doi.org/10.1021/acs.organomet.1c00702
https://hal.archives-ouvertes.fr/hal-03660785

Phosphatetrasilatricyclo[2.1.0.0^2,5]pentane
Lee V. Y., Meguro T., Gapurenko O. A., Minyaev R. M., Minkin V. I., Gornitzka H., Sekiguchi A.
Mendeleev Communications 2022, 32(1), 33-34.
https://doi.org/10.1016/j.mencom.2022.01.009
https://hal.archives-ouvertes.fr/hal-03660695

β-Lactam and penicillin substituted mesoionic metal carbene complexes
Avello M. G., Moreno-Latorre M., de la Torre M. C., Casarrubios L., Gornitzka H., Hemmert C., Sierra M. A.
Organic & Biomolecular Chemistry 2022, 20(13), 2651-2660.
http://dx.doi.org/10.1039/D2OB00216G
https://hal.archives-ouvertes.fr/hal-03660770

Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis
Cherifi C., Latourte A., Vettorazzi S., Tuckermann J., Provot S., Ea H. K., Ledoux A., Casas J., Cuvillier O., Richette P., Ostertag A., Hay E., Cohen-Solal M.
Osteoarthritis and Cartilage 2021, 29 (9), 1335-1345.
https://doi.org/10.1016/j.joca.2021.06.001
https://hal.science/hal-04202734

Cyclic poly(α-peptoid)s by lithium bis(trimethylsilyl)amide (LiHMDS)-mediated ring-expansion polymerization: Simple access to bioactive backbones
Salas-Ambrosio P., Tronnet A., Since M., Bourgeade-Delmas S., Stigliani J.-L., Vax A., Lecommandoux S., Dupuy B., Verhaeghe P., Bonduelle C.
Journal of the American Chemical Society 2021, 143(10), 3697-3702.
https://doi.org/10.1021/jacs.0c13231
https://hal.archives-ouvertes.fr/hal-03173586

Gold(III) porphyrins: Synthesis and interaction with G-quadruplex DNA
Rundstadler T., Mothes E., Amrane S., Stigliani J.-L., Verhaeghe P., Pratviel G.
Journal of Inorganic Biochemistry 2021, 223, 111551/1-10.
https://doi.org/10.1016/j.jinorgbio.2021.111551
https://hal.archives-ouvertes.fr/hal-03312437

Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites
Ouji M., Nguyen M., Mustière R., Jimenez T., Augereau J.-M., Benoit-Vical F., Deraeve C.
Bioorganic & Medicinal Chemistry Letters 2021, 39, 127884/1-6.
https://doi.org/10.1016/j.bmcl.2021.127884
https://hal.archives-ouvertes.fr/hal-03170976

®-BINOL-6,6’-bistriflone: Shortened synthesis, characterization, and enantioselective catalytic applications
Mouhtady O., Castellan T., André-Barrès C., Gornitzka H., Fabing I., Saffon-Merceron N., Génisson Y., Gaspard H.
European Journal of Organic Chemistry 2021, 2021(48), 6674-6681.
https://doi.org/10.1002/ejoc.202101137
https://hal.archives-ouvertes.fr/hal-03511667

Titanium germylidenes
Lee V. Y., Sakai R., Takanashi K., Gapurenko O. A., Minyaev R. M., Gornitzka H., Sekiguchi A.
Angewandte Chemie, International Edition 2021, 60(8), 3951-3955.
https://doi.org/10.1002/anie.202015704
https://hal.archives-ouvertes.fr/hal-03203959

Chlorinated bianthrones from the cyanolichen Nephroma laevigatum
Lagarde A., Mambu L., Mai P.-Y., Champavier Y., Stigliani J.-L., Beniddir M. A., Millot M.
Fitoterapia 2021, 149, 104811/1-8.
https://doi.org/10.1016/j.fitote.2020.104811
https://hal.archives-ouvertes.fr/hal-03203919

Metallodrug profiling against SARS-CoV-2 target proteins identifies highly potent inhibitors of the S/ACE2 interaction and the Papain-like protease PL^pro
Gil-Moles M., Türck S., Basu U., Pettenuzzo A., Bhattacharya S., Rajan A., Ma X., Büssing R., Wölker J., Burmeister H., Hoffmeister H., Schneeberg P., Prause A., Lippmann P., Kusi-Nimarko J., Hassell-Hart S., McGown A., Guest D., Lin Y., Notaro A., Vinck R., Karges J., Cariou K., Peng K., Qin X., Wang X., Skiba J., Szczupak Ł., Kowalski K., Schatzschneider U., Hemmert C., Gornitzka H., Milaeva E. R., Nazarov A. A., Gasser G., Spencer J., Ronconi L., Kortz U., Cinatl J., Bojkova D., Ott I.
Chemistry – A European Journal 2021, 27(71), 17928-17940.
https://doi.org/10.1002/chem.202103258
https://hal.archives-ouvertes.fr/hal-03413330

Synthesis, characterization, and antileishmanial activity of neutral gold(I) complexes with N-heterocyclic carbene ligands bearing sulfur-containing side arms
Ftouh S., Bourgeade-Delmas S., Belkadi M., Deraeve C., Hemmert C., Valentin A., Gornitzka H.
Organometallics 2021, 40(10), 1466-1473.
https://doi.org/10.1021/acs.organomet.1c00113
https://hal.archives-ouvertes.fr/hal-03233814