Molecules and Composites for Optics (Team R)

LCC

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Overview

The synthesis and characterization of new photoactive molecular materials are at the heart of the team’s work. The ruthenium nitrosyl complexes, due to their wide range of physicochemical properties, concentrate a large part of our activity.

Theoretical prediction of these properties allows us to efficiently guide the experimenters towards the best synthetic targets. Obtaining nanometric aggregates of these molecular objects is also part of the team’s strategies.

Our interest in these systems lies in their photoreactivity which allows us to consider applications in photodynamic therapy or in optical information storage.

 

Members of the team

All
Professeur (UT3)

MALFANT Isabelle
Directeur de recherche CNRS, HDR

BALTAS Michel
Maître de conférences

DE BONNEVAL Benedicte
Professeur (UT3)

DE CARO Dominique
Master 2

GZAM Hazem
PhD student

JUAREZ MARTINEZ Yael
Chercheur post-doctoral

LABRA VÁZQUEZ Pablo
Directeur de recherche DR1

LACROIX Pascal
PhD student

MUDRAK Vladyslav
SU Hang
PhD student

SU Hang
TASSE Marine
Team R & AFM service manager

TASSE Marine
Student

TOUNSI Imène
PhD student

XIAO Yue
Student

ZARRAD Manar

No Results Found

Professeur (UT3)

MALFANT Isabelle

Team R

ORCID number : 0000-0002-1185-2124

I. MALFANT studied physical chemistry at the University of Orsay, where she received a PhD in 1990 for her work in Bioinorganic Chemistry. Then, she joined the group of B. M. Hoffman at Northwestern University, US working on electron transfer in hemoglobins. She became associate professor in 1992 and professor in 2007 in LCC working on molecular photoactive materials. Since 2011, she is at the head of the group MCO (team R). She is the author of over 95 publications and 7 patents (h-index = 28).

Email:isabelle.malfant(at)lcc-toulouse.fr

Phone:05.61.33.31.01

Office:B019

Team:R

Directeur de recherche CNRS, HDR

BALTAS Michel

Team R

Email:michel.baltas(at)lcc-toulouse.fr

Phone:05.61.33.31.38

Office:B021

Team:R

Maître de conférences

DE BONNEVAL Benedicte

Team R

Email:benedicte.debonneval(at)lcc-toulouse.fr

Phone:05.61.33.31.52

Office:B019

Team:R

Professeur (UT3)

DE CARO Dominique

Team R

ORCID number : 0000-0003-0291-2575

Après un doctorat (1995) et un post-doc (1996) dans le domaine des nanoparticules métalliques, j’ai été recruté en tant que maître de conférences à l’université Paul Sabatier de Toulouse dans l’équipe « Molécules et Matériaux ». Je me suis alors intéressé à la préparation de films minces (par voie gazeuse ou par voie électrolytique) de conducteurs et d’aimants moléculaires. J’ai été nommé professeur à l’université Paul Sabatier de Toulouse en 2010 et j’ai pris la direction de l’équipe « Molécules et Matériaux » en 2012. De 2010 à 2020, j’ai animé la thématique dédiée à la synthèse de nanoparticules de conducteurs moléculaires. En 2021, j’ai rejoint l’équipe « Molécules et Composites pour l’Optique ». Je m’intéresse à la préparation d’agrégats nanométriques de complexes nitrosyles du ruthénium pour des applications en photothérapie dynamique. Je suis auteur ou co-auteur de 91 publications dans des revues internationales, de 3 chapitres d’ouvrages et de 3 brevets. J’assure des enseignements dans les cycles L et M, principalement en chimie générale (cinétique, thermodynamique, électrochimie), en spectroscopie (de vibration et atomique), en chimie des solides et des matériaux ainsi qu’en méthodes mathématiques pour la physique.

Email:dominique.decaro(at)lcc-toulouse.fr

Phone:05.61.33.31.88

Office:B023

Team:R

Master 2

GZAM Hazem

Team R

Email:hazem.gzam(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

PhD student

JUAREZ MARTINEZ Yael

Team R

Email:yael.juarezmartinez(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

Chercheur post-doctoral

LABRA VÁZQUEZ Pablo

Team R

ORCID number : https://orcid.org/0000-0002-8843-9709

Email:pablo.labra(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

Directeur de recherche DR1

LACROIX Pascal

Team R

ORCID number : 0000-0002-5676-6924

Pascal G. LACROIX is a chemical engineer from the national school of chemistry of Strasbourg (ENSCS). He started working at the CNRS in 1984 at the University of Orsay (France), then in the Laboratoire de Chimie de Coordination (Toulouse, France) since 1994. He was promoted CNRS Research Director in 2004. He has been engaged in an active collaboration with Mexico, and he became a member of the Mexican Academy of Science, in 2018. His current research interest is on Ruthenium nitroxyl complexes.

Email:pascal.lacroix(at)lcc-toulouse.fr

Phone:05.61.33.31.88

Office:B023

Team:R

PhD student

MUDRAK Vladyslav

Team R

Email:vladyslav.mudrak(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

PhD student

SU Hang

Team R

Email:hang.su(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

Team R & AFM service manager

TASSE Marine

Team RAFM

Email:marine.tasse(at)lcc-toulouse.fr

Phone:05.61.33.31.52

Phone:05.61.33.32.15

Office:B019 / S02

Team:R / AFM

Student

TOUNSI Imène

Team R

Email:imene.tounsi(at)lcc-toulouse.fr

Phone:05.61.33.32.36

Office:G173

Team:M/R

PhD student

XIAO Yue

Team R

PhD Student working on antibacterial and wound healing properties of Ruthenium Nitrosyl (Ru-NO) complexes. Yue was born in China, grown up in France.

She completed her undergraduate studies in La Rochelle and her graduate studies in Paris, at Sorbonne University.

Yue enjoys skiing during winter, surfing during summer, and a beer after work when Covid allows it. “Chemistry is not a tool restricted to make carbon-carbon bond. It’s a tool of choice to study life.” – Andrée Marquet (UPMC).

She studies drug-design based on light controlled NO release nitrosyl ruthenium complexes: Antibacterial and wound healing agents in collaboration with LGC and IMRCP (Toulouse). PhD project funded by ANR.

Email:yue.xiao(at)lcc-toulouse.fr

Phone:05.61.33.31.01

Office:B019

Team:R

Student

ZARRAD Manar

Team R

Email:manar.zarrad(at)lcc-toulouse.fr

Phone:05.61.33.31.97

Office:B016

Team:R

Research topics

Applications in the field of health

Given the difficulties encountered by conventional antibiotics in treating certain infections, particularly those caused by biofilms, there is an urgent need to develop new therapies to combat antimicrobial resistance.

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Team news

Highlight 2022 Team R

Highlight 2022 Team R

Apr 14, 2023 |

Ruthenium complexes with nitrosyl ligands are used to non-invasively release nitric oxide through light irradiation using the “two-photon absorption” (TPA) technique, and bimetallic complexes exhibit a five-fold higher sTPA value compared to monometallic complexes.

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Publications

2024

Mechanochemical cleavage of wheat lignin into a more homogeneous fraction
Cachet N., Lavedan P., Baltas M., Benjelloun-Mlayah B.
Industrial Crops and Products 2024, 221, 119321/1-13.
https://doi.org/10.1016/j.indcrop.2024.119321
https://hal.science/hal-04693246

Photorelease of nitric oxide from Pluronic F127/chitosan hydrogels incorporating a water soluble ruthenium nitrosyl complex
Gzam H., Katar D., Tassé M., Xiao Y., Malfant I., Fitremann J., Vicendo P., Mingotaud A.-F., de Caro D.
New Journal of Chemistry 2024, 48(18), 8343-8351.
http://dx.doi.org/10.1039/D4NJ00724G
https://hal.science/hal-04668795

Photorelease of nitric oxide (NO) in mono- and bimetallic ruthenium nitrosyl complexes: A photokinetic investigation with a two-step model
Juarez-Martinez Y., Labra-Vázquez P., Lacroix P. G., Tassé M., Mallet-Ladeira S., Pimienta V., Malfant I.
Inorganic Chemistry 2024, 63(17), 7665-7677.
https://doi.org/10.1021/acs.inorgchem.3c04496
https://hal.science/hal-04666484

Fused double oxazolidine vs Imine ligands and Zn-complexes formation: Experimental and theoretical calculations
Sánchez-Portillo P., Morales-Morales D., Grévy J. M., Lacroix P. G., Flores V. E. G., Barba V.
Journal of Molecular Structure 2024, 1310, 138306/1-11.
https://doi.org/10.1016/j.molstruc.2024.138306
https://hal.science/hal-04590913

Ruthenium nitrosyl complexes with NO release capability: the use of fluorene as an antenna
Mudrak V., Lacroix P. G., Tassé M., Mallet-Ladeira S., Roshal A. D., Malfant I.
Dalton Transactions 2024, 53(23), 9777-9791.
http://dx.doi.org/10.1039/D4DT01154F
https://hal.science/hal-04580926

2023

A Trojan horse approach for enhancing the cellular uptake of a ruthenium nitrosyl complex
Labra-Vázquez P., Rocha E., Xiao Y., Tassé M., Duhayon C., Farfán N., Santillan R., Gibot L., Lacroix P. G., Malfant I.
Dalton Transactions 2023, 52(48), 18177-18193.
http://dx.doi.org/10.1039/D3DT03480A
https://hal.science/hal-04346306

Acetylacetonate ruthenium nitrosyls: A gateway to nitric oxide release in water under near-infrared excitation by two-photon absorption
Labra-Vázquez P., Mudrak V., Tassé M., Mallet-Ladeira S., Sournia-Saquet A., Malval J.-P., Lacroix P. G., Malfant I.
Inorganic Chemistry 2023, 62(49), 20349-20363.
https://doi.org/10.1021/acs.inorgchem.3c03355
https://hal.science/hal-04284209

Crystal structures and conformational effects in bis-fluorenyl based ligands and related ruthenium nitrosyl complexes
Juarez-Martinez Y., Labra-Vázquez P., Lacroix P. G., Tassé M., Bocé M., Mallet-Ladeira S., Malfant I.
Polyhedron 2023, 246, 116690/1-10.
https://doi.org/10.1016/j.poly.2023.116690
https://hal.science/hal-04283893

First example of photorelease of nitric oxide from ruthenium nitrosyl-based nanoparticles
Farhat A., Tassé M., Bocé M., de Caro D., Malfant I., Vicendo P., Mingotaud A.-F.
Chemical Physics Letters 2023, 818, 140434/1-4.
https://doi.org/10.1016/j.cplett.2023.140434
https://hal.science/hal-04034750

2022

Two-photon absorption-based delivery of nitric oxide from ruthenium nitrosyl complexes
Lacroix P. G., Malfant I., Labra-Vázquez P., Fárfan N., Ramos-Ortiz G.
Dalton Transactions 2022, 51(39), 14833-14841.
http://dx.doi.org/10.1039/D2DT02553A
https://hal.archives-ouvertes.fr/hal-03796675

Bimetallic ruthenium nitrosyl complexes with enhanced two-photon absorption properties for nitric oxide delivery
Juarez-Martinez Y., Labra-Vázquez P., Enríquez-Cabrera A., Leon-Rojas A. F., Martínez-Bourget D., Lacroix P. G., Tassé M., Mallet-Ladeira S., Farfán N., Santillan R., Ramos-Ortiz G., Malval J.-P., Malfant I.
Chemistry – A European Journal 2022, 28(62), e202201692/1-14.
https://doi.org/10.1002/chem.202201692
https://hal.archives-ouvertes.fr/hal-03796799

2021

Two-photon absorption properties in « push-pull » ruthenium nitrosyl complexes with various fluorenylterpyridine-based ligands
Bukhanko V., León-Rojas A. F., Lacroix P. G., Tassé M., Ramos-Ortiz G., Barba-Barba R. M., Farfán N., Santillan R., Malfant I.
European Journal of Inorganic Chemistry 2021, 2021(17), 1670-1684.
https://doi.org/10.1002/ejic.202100109
https://hal.archives-ouvertes.fr/hal-03228987

Characterization of charge states in conducting organic nanoparticles by X-ray photoemission spectroscopy
Fraxedas J., Vollmer A., Koch N., de Caro D., Jacob K., Faulmann C., Valade L.
Materials 2021, 14(8), 2058/1-13.
https://doi.org/10.3390/ma14082058
https://hal.archives-ouvertes.fr/hal-03219545

First nanoparticles of a conductor based on the organic donor molecule BETS: κ-(BETS)2FeCl4
Jacob K., Faulmann C., de Caro D., Valade L.
Materials 2021, 14(16), 4444/1-7.
https://doi.org/10.3390/ma14164444
https://hal.archives-ouvertes.fr/hal-03364498

Crystal structure of 1,1’-(pyridine-2,6-diyl)bis[N-(pyridin-2-ylmethyl)methanaminium] dichloride dihydrate
Merabet L., Tasse M., Mallet-Ladeira S., Kaboub L., Malfant I.
Acta Crystallographica Section E 2021, 77(12), 1296-1298.
https://doi.org/10.1107/S205698902101183X
https://hal.archives-ouvertes.fr/hal-03600453

Amplitude mode of charge density wave in TTF[Ni(dmit)2]2 observed by electronic Raman scattering
Revelli Beaumont M., Gallais Y., Sacuto A., Jacob K., Valade L., de Caro D., Faulmann C., Cazayous M.
Physical Review B 2021, 103(3), 035139/1-5.
https://doi.org/10.1103/PhysRevB.103.035139
https://hal.archives-ouvertes.fr/hal-03229054

Superconducting super-organized nanoparticles of the superconductor (BEDT-TTF)2Cu(NCS)2
de Caro D., Jacob K., Revelli-Beaumont M., Faulmann C., Valade L., Tassé M., Mallet-Ladeira S., Fan S., Kawamoto T., Mori T., Fraxedas J.
Synthetic Metals 2021, 278, 116844.
https://doi.org/10.1016/j.synthmet.2021.116844
https://hal.science/hal-03364488

Possible observation of the signature of the bad metal phase and its crossover to a Fermi liquid in κ-(BEDT-TTF)2Cu(NCS)2 bulk and nanoparticles by Raman scattering
Revelli Beaumont M., Hemme P., Gallais Y., Sacuto A., Jacob K., Valade L., de Caro D., Faulmann C., Cazayous M.
Journal of Physics: Condensed Matter 2021, 33(12), 125403/1-9.
http://dx.doi.org/10.1088/1361-648X/abd813
https://hal.archives-ouvertes.fr/hal-03229011

Colorimetric metal ion (II) Sensors Based on imine boronic esters functionalized with pyridine
Sánchez-Portillo P., Hernández-Sirio A., Godoy-Alcántar C., Lacroix P. G., Agarwal V., Santillán R., Barba V.
Dyes and Pigments 2021, 186, 108991/1-13.
https://doi.org/10.1016/j.dyepig.2020.108991
https://hal.archives-ouvertes.fr/hal-03108961

Partnerships

Click here to consult the partners
Martial Boggio-Pasqua, LCPQ-IRSAMC, Université de Toulouse 3

Patricia Vicendo, Anne-Françoise Mingotaud, IMRCP, Université de Toulouse 3

Christine Roques, LGC, Université de Toulouse 3

Marie-Pierre Rols, IPBS-CNRS, Toulouse

Marylise Buron-Lecointe, IPR, Université de Rennes 1

Gabriel Ramos, CIO, Mexique

Norberto Farfán, UNAM, Mexique

Zoia Voitenko, Taras Shevchenko National University of Kyiv, Ukraine

Oleksander Roschal, Karazin University of Kharkov, Ukraine

Funding

Click here to consult the funders

French Ministry of Higher Education and Research

International Research Project (IRP) MCCM (France – Mexico)

COMUE Occitania Region

Campus France

ANR Photochromics

ANR NOBaclight

LCC

Laboratoire de chimie de coordination du CNRS

205 route de Narbonne, BP 44099
31077 Toulouse cedex 4
France

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