Our work, combining chemistry and biology, is based on different pharmacological approaches such as the understanding of:
1) the mechanisms of resistance of pathogens to drugs, and
2) the mode of action of molecules of therapeutic interest.
These studies lead to the design, synthesis, evaluation and mechanistic studies of drug candidates for the treatment of pathologies in which transition metals are involved such as malaria, Alzheimer’s disease, etc… Our team is also labelled Inserm (ERL 1289, MAAP).
Mechanisms of Plasmodium resistance and therapeutic targets
Markers of resistance selection
Mechanochemical approaches for the synthesis of antimalarial molecules
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