New antimalarial molecules and pharmacological approaches (Team V)



Our work, combining chemistry and biology, is based on different pharmacological approaches such as the understanding of:

1) the mechanisms of resistance of pathogens to drugs, and

2) the mode of action of molecules of therapeutic interest.

These studies lead to the design, synthesis, evaluation and mechanistic studies of drug candidates for the treatment of pathologies in which transition metals are involved such as malaria, Alzheimer’s disease, etc… Our team is also labelled Inserm (ERL 1289, MAAP).

Members of the team


Research topics

Mechanisms of Plasmodium resistance and therapeutic targets

Markers of resistance selection

Mechanochemical approaches for the synthesis of antimalarial molecules

Alzheimer disease

Team news

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Proteomics evidence of the role of TDMQ20 in the cholinergic system and synaptic transmission in a mouse model of Alzheimer’s disease
Sun F., Zhao J., Zhang H., Shi Q., Liu Y., Robert A., Liu Q., Meunier B.
ACS Chemical Neuroscience 2022, 13(21), 3093–3107.

Design of anti-infectious agents from lawsone in a three-component reaction with aldehydes and isocyanides
Koumpoura C. L., Nguyen M., Bijani C., Vendier L., Salina E. G., Buroni S., Degiacomi G., Cojean S., Loiseau P. M., Benoit-Vical F., García-Sosa A. T., Robert A., Baltas M.
ACS Omega 2022, 7(40), 35635-35655.

In vitro and in silico antimalarial evaluation of FM-AZ, a new artemisinin derivative
Tsamesidis I., Mousavizadeh F., Egwu C. O., Amanatidou D., Pantaleo A., Benoit-Vical F., Reybier K., Giannis A.
Medicines 2022, 9(2), 8/1-12.

How to define a nanozyme
Robert A., Meunier B.
ACS Nano 2022, 16(5), 6956-6959.

Mutation in the Plasmodium falciparum BTB/POZ domain of K13 protein confers artemisinin resistance
Paloque L., Coppée R., Stokes B. H., Gnädig N. F., Niaré K., Augereau J.-M., Fidock D. A., Clain J., Benoit-Vical F.
Antimicrobial Agents and Chemotherapy 2022, 66(1), e01320-21.

X-Ray diffraction structure of Cu(II) and Zn(II) complexes of 8-aminoquinoline derivatives (TDMQ), related to the activity of these chelators as potential drugs against Alzheimer’s disease
Li Y., Nguyen M., Vendier L., Robert A., Liu Y., Meunier B.
Journal of Molecular Structure 2022, 1251, 132078/1-6.

Synthesis and antimalarial activities of new hybrid Atokel molecules
Li Y., Loureiro A., Nguyen M., Laurent M., Bijani C., Benoit-Vical F., Robert A., Liu Y., Meunier B.
ChemistryOpen 2022, 11(5), e202200064/1-20.

Resistance to artemisinin in falciparum malaria parasites: A redox-mediated phenomenon
Egwu C. O., Pério P., Augereau J.-M., Tsamesidis I., Benoit-Vical F., Reybier K.
Free Radical Biology and Medicine 2022, 179, 317-327.


TDMQ20, a specific copper chelator, reduces memory impairments in Alzheimer’s disease mouse models
Zhao J., Shi Q., Tian H., Li Y., Liu Y., Xu Z., Robert A., Liu Q., Meunier B.
ACS Chemical Neuroscience 2021, 12(1), 140-149.

Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites
Ouji M., Nguyen M., Mustière R., Jimenez T., Augereau J.-M., Benoit-Vical F., Deraeve C.
Bioorganic & Medicinal Chemistry Letters 2021, 39, 127884/1-6.

Antimalarial inhibitors targeting epigenetics or mitochondria in Plasmodium falciparum: Recent survey upon synthesis and biological evaluation of potential drugs against malaria
Koumpoura C. L., Robert A., Athanassopoulos C. M., Baltas M.
Molecules 2021, 26(18), 5711/1-34.

Elucidation of the Diels-Alder reaction kinetics between diphenylfulvene and maleimide by mechanochemistry and in solution
Gonnet L., Chamayou A., André-Barrès C., Micheau J.-C., Guidetti B., Sato T., Baron M., Baltas M., Calvet R.
ACS Sustainable Chemistry & Engineering 2021, 9(12), 4453-4462.

Synthesis of biologically relevant 1,2,3- and 1,3,4-triazoles: From classical pathway to green chemistry
Gonnet L., Baron M., Baltas M.
Molecules 2021, 26(18), 5667/1-27.

Superoxide: A major role in the mechanism of action of essential antimalarial drugs
Egwu C. O., Tsamesidis I., Pério P., Augereau J.-M., Benoit-Vical F., Reybier K.
Free Radical Biology and Medicine 2021, 167, 271-275.

Reactive oxygen species as the brainbox in malaria treatment
Egwu C. O., Augereau J.-M., Reybier K., Benoit-Vical F.
Antioxidants 2021, 10(12), 1872/1-20.

A new thienopyrimidinone chemotype shows multistage activity against Plasmodium falciparum, including artemisinin-resistant parasites
Bosson-Vanga H., Primas N., Franetich J.-F., Lavazec C., Gomez L., Ashraf K., Tefit M., Soulard V., Dereuddre-Bosquet N., Le Grand R., Donnette M., Mustière R., Amanzougaghene N., Tajeri S., Suzanne P., Malzert-Fréon A., Rault S., Vanelle P., Hutter S., Cohen A., Snounou G., Roques P., Azas N., Lagardère P., Lisowski V., Masurier N., Nguyen M., Paloque L., Benoit-Vical F., Verhaeghe P., Mazier D., Muralidharan V.
Microbiology Spectrum 2021, 9(2), e00274-21/1-19.

2-phenoxy-3-trichloromethylquinoxalines are antiplasmodial aerivatives with activity against the apicoplast of Plasmodium falciparum
Amrane D., Arnold C.-S., Hutter S., Sanz-Serrano J., Collia M., Azqueta A., Paloque L., Cohen A., Amanzougaghene N., Tajeri S., Franetich J.-F., Mazier D., Benoit-Vical F., Verhaeghe P., Azas N., Vanelle P., Botté C., Primas N.
Pharmaceuticals 2021, 14(8), 724/1-24.

“Nanozymes” without catalytic activity should be renamed
[Unpublished work], 2021
Nguyen M., Robert A., Meunier B.


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Youzhi Li (PhD 2019-2022): post-doc position, Hong-Kong

Chinedu Egwu (PhD 2018-2021): Professor assistant, FUNAI University, Nigeria

Thibaud Reyser (PhD 2017-2020): Technical Service Scientist, Merck KGaA

Manel Ouji (PhD 2017-2020): Medical Information Officer, Pfizer

Sokhna Keita Alassane (PhD 2013-2016)

Arba Pramundita Ramadani (PhD 2013-2017): Professor Assistant, Department of Pharmacy Yogyakarta, Indonesia


Useful links

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Laboratoire de chimie de coordination du CNRS

205 route de Narbonne, BP 44099
31077 Toulouse cedex 4

+ 33 5 61 33 31 00