Seminar Pr Takashi Matsuo

Pr Takashi Matsuo

NAIST, Japan

Functionalization of olefin metathesis catalysts for synthetic and biochemical applications

Olefin metathesis, a carbon-carbon rearrangement reaction, is an important type of reaction in organic synthesis. The most popular catalyst for olefin metathesis is the ruthenium complex with an N-heterocyclic carbene ligand and benzylidene ligand (so-called “Hoveyda-Grubbs 2nd generation catalyst”), because the complex is relatively stable in the presence of moisture and air. Recently, some research groups around the world have attempted to improve the reactivity of the catalyst by structural modifications of the ligand moieties, while others have used the catalyst to modify biomolecules in aqueous media. In this talk, I will present our recent interdisciplinary work on olefin metathesis catalysts in the fields of catalyst chemistry and biomolecular chemistry, including the construction of artificial metalloenzymes catalyzing olefin metathesis and ligand modification aiming at the second coordination sphere effect.

Références
1. Synthesis and Reactivity of an Olefin Metathesis-Catalyzing Ruthenium Complex with a Selenoether Moiety in the Benzylidene Ligand. Tsubasa Kinugawa, Seishu Mitsusada, Naoki Orito, Takashi Matsuo*, ACS Omega, 2024, 9, 51604.
2. Reactivity Regulation for Olefin Metathesis-catalyzing Ruthenium Complexes with Sulfur Atoms at the Terminal of 2-Alkoxybenzylidene Ligands. Tsubasa Kinugawa, Takashi Matsuo*, Dalton Trans. 2023, 52, 9499.
3. Second-coordination Sphere Effects on Reactivities of Hoveyda–Grubbs-type Catalysts: A Ligand Exchange Study Using Phenolic Moiety-functionalized Ligands. Catur Jatmika, Kenta Goshima, Kazumo Wakabayashi, Naoki Akiyama, Shun Hirota, Takashi Matsuo*, Dalton Trans. 2023, 49, 11618.