Corentin Bouvier awarded the FEBS Journal Prize for his PhD research

Corentin Bouvier was awarded the FEBS Journal Prize on 23 May 2025 during the 4th Annual Meeting of the ProteoCure COST Action, held in Heraklion, Greece. The prize recognises the excellence of his scientific poster presentation.

Now a postdoctoral researcher, Corentin Bouvier received this award for the work he carried out during his PhD within the “Dendrimers and Heterochemistry” team (Team M) at the Laboratory of Coordination Chemistry (LCC). His research focused on the design of PROTACs, hybrid molecules that trigger the targeted degradation of proteins, with the aim of restoring the sensitivity of tumour cells to proteasome inhibitors. He specifically investigated the E3 ligase TRIM24, identified as a key player in resistance mechanisms involving proteaphagy, a protein degradation pathway hijacked by certain cancer cells. By targeting TRIM24, the objective is to block this adaptive mechanism and enhance therapeutic efficacy.

This work was carried out in collaboration with B-molecular, the Cancer Research Center of Toulouse (CRCT), PharmaDev, and the Josep Carreras Leukaemia Research Institute.