Seminar Dr. Bruno ALIES

Dr. Bruno Alies

ChemBioPharm – ARNA
Université de Bordeaux – Inserm U1212 – UMR CNRS 5320, Bordeaux, France

NucleoLipids: biocompatible supramolecular edifices with a wide range of applications.
A journey from metal ions sensing to 3D cell culture hydrogels.

NucleoLipids (NL) are bioinspired amphiphilic molecules composed of a hydrophilic nucleotide or oligonucleotide moiety and a hydrophobic phospholipid or derivative.(1) Their amphiphilicity drives the self-assembly into SupraMolecular Edifices (SME), which can cross membranes,(2) including the blood-brain barrier.(3) The nitrogen-containing nucleobases of NL can coordinate metal ions, leading to structural modifications of the resulting SME.(4)
In this talk, I will highlight the versatile potential of NL and their SME in health-related applications. These structures can function as nanocarriers for drug delivery,(5,6) stimuli-responsive materials for controlled release,(7) and tunable scaffolds for 3D cell culture.(8,9) Special emphasis will be placed on their interactions with metal ions.

References

(1) Rosemeyer, H. Nucleolipids Chem. Biodivers. 2005, 2 (8), 977–1063.
(2) Kauss, T.; Arpin, C.; Bientz, L.; Vinh Nguyen, P.; Vialet, B.; Benizri, S.; Barthélémy, P. Sci. Rep. 2020, 10 (1), 1054.
(3) Swastika; Chaturvedi, S.; Kaul, A.; Hazari, P. P.; …; Pal, S.; Lal, S.; Singh, B.; Barthélémy, P.; Mishra, A. K. Int. J. Pharm. 2019, 565, 269–282.
(4) Alies, B.; Ouelhazi, M. A.; Noireau, A.; Gaudin, K.; Barthélémy, P. Anal. Chem. 2019, 91 (3), 1692–1695.
(5) Benizri, S.; Ferey, L.; Alies, B.; Mebarek, N.; Vacher, G.; …; Staedel, C.; Gaudin, K.; Barthélémy, P. Nanoscale Res. Lett. 2018, 13 (1), 17.
(6) Kowouvi, K.; Alies, B.; Gendrot, M.; Gaubert, A.; …; Pradines, B.; Barthelemy, P.; Grislain, L.; Millet, P. RSC Adv. 2019, 9 (33), 18844–18852.
(7) Alies, B.; A. Ouelhazi, M.; Patwa, A.; Verget, J.; Navailles, L.; Desvergnes, V.; Barthélémy, P. Org. Biomol. Chem. 2018, 16 (26), 4888–4894.
(8) El Hamoui, O.; Saydé, T.; …; Barthélémy, P.; Gaudin, K.; Battu, S.; Lespes, G.; Alies, B. ACS Biomater. Sci. Eng. 2022, 8 (8), 3387–3398.
(9) Saydé, T.; Hamoui, O. E.; Alies, B.; …; Lacomme, S.; Barthélémy, P.; Lespes, G.; Battu, S.; Gaudin, K. J. Chromatogr. A 2024, 1736, 465393.