Diverse Approaches for the Difunctionalization of PPH Dendrimers, Precise Versus Stochastic: How Does this Influence Catalytic Performance?

Massimo Petriccone, Régis Laurent, Anne-Marie Caminade,* and Rosa María Sebastián*
ACS Macro Lett. 2024, 13, 7, 853–858
Publication Date: June 25, 2024
https://doi.org/10.1021/acsmacrolett.4c00204

This work shows for the first time that when two functions are well organised on the surface of dendrimers, catalysis is systematically more efficient than if the two functions are randomly distributed.

Difunctionalisation of dendrimer surfaces is often used in biology. Until now, the compounds used have mostly been randomly distributed. It is in fact difficult to obtain precise difunctionalisation on most dendrimers. In this study, the scientists used polyphosphorhydrazone (PPH)-based dendrimers and demonstrated that with them a single precise difunctionalisation is possible. Catalysis research shows that precise functionalisation is systematically more effective than random functionalisation, introducing an entirely new concept in dendrimer science.

Research carried out in collaboration between a team from the LCC and a team from UAB Barcelona.

Contact:
Anne-Marie Caminade Anne-Marie.Caminade(at)lcc-toulouse.fr