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Seminar Dr. Rafael GRAMAGE-DORIA

Friday 16 June 2023 de 11:00 - 12:00


Institut des Sciences Chimiques de Rennes


“From sustainable transformations to supramolecular approaches in catalysis”

The generation of more efficient, atom- and step-economy transformations is of primary importance to meet the societal challenges associated the 21st century. In this context, transition metal catalysis is an enabling technology and in our laboratories we have developed a number of sustainable approaches dealing with C-H bond functionalizations, one-pot multi-step sequences, direct reductive aminations, and oxidations.[1] They aim at minimizing chemical wastes while controlling metal’s activity and selectivity. On another hand, we have developed metal-catalyzed transformations which are controlled by remote, kinetically labile interactions taking place in the secondary coordination sphere of the metal catalyst.[2] In particular, we have exploited the reversible binding between nitrogencontaining substrates and metalloporphyrins via Zn…N weak interactions as a tool for the design of supramolecular catalysts. These supramolecular catalysts feature unique atom-precise selectivities that enables to tackle challenging chemical transformations besides displaying enzyme-like behaviors such as substrate selectivity and Michaelis-Menten kinetics.[3]

[1] For selected examples see:
(a) Adv. Synth. Catal. 2016, 358, 3847; (b) Org. Lett. 2017, 19, 6404; (c) Catal. Sci. Technol. 2019, 9, 4711; (d) Catal. Sci. Technol. 2020, 10, 180; (e) Catal. Sci. Technol. 2021, 11, 5772; (f) Chem. Eur. J. 2022, 28, e202201078; (g) Org. Chem. Front. 2023, 10, 42; (h) ACS Catal. 2023, 13, 4421; (i) ACS Catal. 2023, 13, 2367.
[2] For reviews, see:
(a) Chem. Soc. Rev. 2021, 50, 3565; (b) Angew. Chem. Int. Ed. 2023, 62, e202211016.
[3] (a) Chem. Eur. J. 2017, 23, 5033; (b) Chem. Eur. J. 2019, 25, 627; (c) Angew. Chem. Int. Ed. 2021, 60, 18006; (d) Chem. Eur. J. 2022, 28, e202201970; (e) Faraday Discuss. 2023, in press; (f) ACS Catal. 2023, preliminary accepted.


Friday 16 June 2023
11:00 - 12:00
Event Categories:


Dr Jean-Pascal SUTTER


Salle Gallais, LCC
205 Rte de Narbonne
Toulouse, Midi-Pyrénées 31400 France
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